Extended monod kinetics for substrate inhibited systems

Application of a substrate inhibition model to estimate the effect of fructose concentration on the growth of diverse Saccharomyces cerevisiae strains

“…A similar result was also obtained for glucose and Actinobacillus succinogenes in a semi-defined medium by Lin et al [16]. The optimum sucrose concentration for growth of a mixed culture of microorganism was attained at 0.2% [25]. In this work, optimum fructose concentrations for S. cerevisiae and S. bayanus strains were always above these values.…”

“…The effects of glucose and sucrose concentration on microbial growth had been previously studied and fitted with a substrate inhibition model by Sivakumar et al [25]. These authors showed that a glucose concentration around 2% produced a maximum in Klebsiella oxytoca growth, but Table 1 Kinetic parameters (± standard deviation) obtained from curves of Fig.…”

“…Several mathematical models have been developed for quantifying the inhibitory effect of substrate concentration on microbial growth. Generally, these models are adaptations of modified Monod equations for substrate inhibition of enzymatic reactions [16,17,25].…”

Production of β-galactosidase in a Batch Bioreactor Using Whey through Microbial Route – Characterization of Isolate and Reactor Model

“…From the experimental results it was observed that microbial growth rate was inhibited by high lactose concentration (>20 g/L) and there was no microbial growth at lactose concentration 180 g/L in microbial growth medium. Therefore, critical concentration of lactose, [c lac *] in microbial growth medium was considered to be 180 g/L [25][26][27]. The kinetic parameter of the logistic model, k, was evaluated through regression analysis for each batch type of experiment using the experimental values of initial specific growth rate, μ, and corresponding biomass concentration [11,23,33].…”

Modeling of p-nitrophenol biodegradation by Ralstonia eutropha via application of the substrate inhibition concept

“…In spite of complexity of these types of phenomena as related to microbe's growth, often a single enzymatic reaction having a simple expression is used to describe the overall rate of growth. However simple model such as Monod kinetics for growth may fail in some cases for instance when inhibitory effects are due to excess of a particular substrate [8]. The relationship between substrate and during biological adaptation of the microorganism to an * Corresponding author.…”