Extended human papillomavirus genotype distribution in cervical intraepithelial neoplasia and cancer: Analysis of 40 352 cases from a large academic gynecologic center in China

Tang, Xiao; Jones, Terri E; Jiang, Wei; Austin, Marshall; He, Yanjin; Li, Lei; Tong, Lingling; Wang, Cheng; Yang, Kaixuan; Yin, Rutie; Zhao, Chengquan

doi:10.1002/jmv.28302

Cited by 11 publications

(20 citation statements)

References 46 publications

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“…Moreover, HPV-51, a non-vaccine genotype, ranks as the third most frequent high-risk genotype in our study. Hence, recognizing the significant role of HR-HPV types in causing cancer, particularly contributing to 94.1% of squamous cell carcinomas and 83.3% of cervical adenocarcinomas [ 40 ], emphasizes the crucial need to prioritize preventive and control measures for this infection. It is essential to acknowledge certain limitations in present study.…”

Section: Discussionmentioning

confidence: 99%

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

Haddadi,

Atefmehr,

Motlaghzadeh

et al. 2024

Virol J

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Introduction Human papillomavirus (HPV) presents a potential threat to the onset of carcinogenesis in the cervix, anogenital regions, and oropharynx. HPV encompasses over 200 types, with at least 12 having the potential to cause cancer, impacting the majority of sexually active individuals. In this current research, we explore the occurrence and spread of HPV genotypes. Material and methods During this cross-sectional study conducted in Sanandaj, Iran from Feb 2022 to Aug 2023, diverse samples including oral, vaginal, and genital were collected from individuals referred to private laboratories in Sanandaj, Iran. After sample collection and DNA extraction (FAVORGEN, Taiwan), they were subjected to PCR and genotyping (MehrViru, Iran). The subsequent statistical analysis unveiled infection rates across different demographics and age groups. STATA (version 17) were used for statistical analysis. We examined infection rates across demographics using t-tests and Odds Ratio. Results Overall, 26% (249) out of 950 cases tested positive for HPV, with 69% of these classified as high-risk. Among the examined population, 98% (933) were female, and 2% (17) were male. Females aged 31–40 exhibited the highest percentage of HPV prevalence (115/460) in the study with the majority of positive cases belonging to HR genotypes. The overall most frequent genotypes identified were 6, 16, 52, 53, 51, 58, and 56. HPV-16 exhibited the highest frequency among HR genotypes, accounting for 42 (17%) occurrences, followed by HPV-52 with a frequency of 32 (13%). Conclusion Our findings emphasize the significant prevalence of HPV among females, particularly in the 21–30 age group. The identification of high-risk genotypes, underscores the importance of targeted interventions for specific age cohorts. The age-stratified analysis highlights a consistent predominance of high-risk HPV across age groups, indicating the need for age-specific preventive measures. These results contribute valuable information for designing effective screening and vaccination strategies, to alleviate the impact of diseases associated with HPV.

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Section: Discussionmentioning

confidence: 99%

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

Haddadi,

Atefmehr,

Motlaghzadeh

et al. 2024

Virol J

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“…Cervical squamous and glandular lesions have distinct HPV genotyping patterns ( 14 – 17 , 29 ). In high grade precancerous lesions, HPV16 was the most common type in CIN2/3 (40.1%), while HPV18 was the most common type in AIS (42.1%).…”

Section: Discussionmentioning

confidence: 99%

“…Four potential hrHPV genotypes, HPV53, HPV26, HPV82, and HPV73, were not included in FDA-approved commercial kits, which showed positive rates of 4.2%, 1.0%, 0.9%, and 0.2%, respectively in current study. Previous studies demonstrated that HPV82, 53 had relatively higher risk for CIN2+ lesions in women with slight abnormality Cervical squamous and glandular lesions have distinct HPV genotyping patterns (14)(15)(16)(17)29). In high grade precancerous lesions, HPV16 was the most common type in CIN2/3 (40.1%), while HPV18 was the most common type in AIS (42.1%).…”

Section: B Amentioning

confidence: 95%

HPV genotyping of cervical histologic specimens of 61, 422 patients from the largest women hospital in China

et al. 2023

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ObjectivesWe investigated HPV genotypes in a large cohort of patients with definitive cervical histologic diagnosis.MethodsHPV testing was performed by real-time PCR assay, including 18 high-risk HPV (hrHPV) and 3 low-risk HPV (lrHPV). Totally 61,422 patients with documented HPV genotyping results within 6 months before cervical histologic diagnoses were included.ResultsHrHPV positive rate was 55.1% among all tested cases with the highest in adenosquamous carcinoma (94.1%), followed by squamous cell carcinoma (SCC) (93.7%), cervical intraepithelial neoplasia 2/3 (CIN2/3) (92.8%). HrHPV positive rates were significantly higher in high-grade squamous lesions than in those in glandular lesions. HPV16 was the most common genotype followed by HPV52 and HPV58 in CIN2/3. The most frequent hrHPV genotype in adenocarcinoma in situ (AIS) was HPV18, followed by HPV16, HPV45 and HPV52. In SCC cases, HPV16 was the most common type followed by HPV58, HPV52, HPV18 and HPV33. However, HPV18 showed significantly higher prevalence in adenocarcinoma and adenosquamous carcinoma than in that in SCC. Theoretically, the protective rates of 2/4-valent and 9-valent vaccine were 69.1% and 85.8% for cervical cancers.ConclusionsThe prevalence of HPV genotypes in Chinese population was different from that in Western population. Some hrHPV types were identified in cervical precancerous lesions and cancers, which are not included in current HPV vaccines. These data provide baseline knowledge for future HPV vaccine development.

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“…HR-HPV prevalence was highest in the <30 years group in all categories except SCC and ADC. 13 14 As shown in figure 1 , HPV52, 58 and 53 are involved primarily in the benign or low-grade cervical squamous lesions, while HPV16 is mainly associated with more severe lesions (CIN2/3 and SCC). HPV18 is significantly more common in glandular lesions than in squamous lesions ( figures 1 and 2 ).…”

Section: Distribution Of Hpv Genotypes In Histopathologically Confirm...mentioning

confidence: 99%

“…HPV18 is significantly more common in glandular lesions than in squamous lesions ( figures 1 and 2 ). 13 14 …”

Section: Distribution Of Hpv Genotypes In Histopathologically Confirm...mentioning

confidence: 99%

Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions

Ye,

Jones,

Wang

et al. 2024

gocm

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Across cervical squamous and glandular lesions, a spectrum of human papillomavirus (HPV) genotypes has been identified. This review aims to provide a comprehensive summary detailing the distribution and profile of HPV genotypes detected in cervical lesions, leveraging insights from histological and cytological findings. High-risk HPV (HR-HPV) genotypes exhibit varying degrees of oncogenic potential, with HPV16 and HPV18 identified as the most prevalent and oncogenic types. The distribution of HR-HPV genotypes varies among different degrees of the cervical lesions and varies between squamous and glandular neoplasia. HPV16 is predominantly associated with severe lesions (precancers and carcinomas), while HPV18 demonstrates a significantly higher prevalence in endocervical as compared with squamous neoplasia. The distribution of HR-HPV in severe squamous lesions is complex, involving many HR-HPV genotypes in addition to HPV16, while the distribution of HR-HPV genotypes in endocervical glandular lesions is mainly limited in HPV18 and HPV16.Large datasets from China have identified the three most common HR-HPV genotypes in this population as stratified by diagnostic category: HPV52, HPV16, HPV58 in histologically negative cases and cervical intraepithelial neoplasia 1 (CIN1); HPV16, HPV52, HPV58 in CIN2/3; HPV16, HPV58, HPV52 or HPV18 in squamous cell carcinoma (SCC); HPV16, HPV18 and HPV52 in endocervical adenocarcinoma in situ (AIS), invasive adenocarcinoma, as well as mixed squamous and glandular lesions. HPV33 is the fourth most common HPV type in CIN2/3 and SCC, while HPV45 occurs more commonly in AIS and adenocarcinoma, compared with squamous lesions. The prevalence and distribution of multiple HR-HPV coinfections vary across different cervical diseases. The clinical significance and pathogenesis of these multiple HR-HPV infections remain uncertain, although recent two large studies demonstrate that multiple HR-HPV infections are not associated with cumulatively higher risk of high-grade cervical squamous lesion development, suggesting competitive and/or cooperative interactions among HPV genotypes. Extensive HPV genotyping aids in risk assessment and optimising clinical approaches for women with mild abnormalities in Pap cytology. Women with atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) Pap test results and with the infection of some HR-HPV genotypes carry a very low risk of high-grade cervical lesions. HPV genotyping can allow for risk stratification and triage optimisation for these HR-HPV-positive women. Women with atypical glandular cell (AGC) Pap test results showed a specific HPV genotyping pattern and extended HPV genotyping may be helpful for the clinical management of AGCs. Continual advancements in clinical guidelines integrating extended genotyping would increase diagnostic accuracy and refine strategies in clinical management.

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Extended human papillomavirus genotype distribution in cervical intraepithelial neoplasia and cancer: Analysis of 40 352 cases from a large academic gynecologic center in China

Cited by 11 publications

References 46 publications

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

HPV genotyping of cervical histologic specimens of 61, 422 patients from the largest women hospital in China

Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions

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