Extended Detection of Amphetamine and Methamphetamine in Oral Fluid

Abstract

These data confirm that oral fluid is a viable alternative to urine for monitoring amphetamine abuse, and that these substances might be detected in oral fluid for at least 1 week after ingestion of high doses. Such long detection times were, as far as we are aware, never reported previously for oral fluid amphetamines.

Interpreting oral fluid drug results in prisoners: monitoring current drug intake and detection times for drugs self-administered prior to detention

“…2 and 3) of creatinine-normalized urine results were used for comparison to see if variation in oral fluid results was likely to be the result of new intake during the study. There was a larger variability in elimination curves in oral fluid as compared to creatinine corrected urine curves, in line with the previous findings [27][28][29][30]. In addition, after ingestion of high and repeated drug doses, detection times could be several days.…”

“…As could be expected assuming higher intake, we found a much longer 9 day methamphetamine window of detection than reported in clinical studies, with a 8 µg/L cutoff, Table 3. This is slightly longer than in our previous study from patients undergoing drug detoxification, where the detection window was up to eight days [27]. For amphetamine, a shorter detection window of up to three days was found, Table 3, as compared to the previously reported detection window of up to 8 days for patients undergoing drug detoxification [27].…”

“…This is slightly longer than in our previous study from patients undergoing drug detoxification, where the detection window was up to eight days [27]. For amphetamine, a shorter detection window of up to three days was found, Table 3, as compared to the previously reported detection window of up to 8 days for patients undergoing drug detoxification [27]. It might be difficult to differentiate the effects of amphetamine and methamphetamine [45]; thus there was consistency between the participants' self-reports regarding methamphetamine/amphetamine ingestion and the actual findings in oral fluid/urine.…”

“…Multiple studies documented that oral fluid is a viable matrix for drugs of abuse detection [10][11][12][13][14][15]. Single and low doses are typically administered in controlled drug studies [16][17][18][19][20][21][22][23][24][25][26], although others investigating drug elimination purported high doses from patients admitted for drug detoxification [27][28][29][30] or after chronic frequent use [31; 32] reported increased drug detection times. Since many prisoners use high and/or chronic doses of drugs of abuse before incarceration, elimination and detection times of drugs of abuse in oral fluid from this population provide relevant data for future interpretation of oral fluid tests.…”

Simultaneous Determination of Methamphetamine and Its Isomer N-Isopropylbenzylamine in Forensic Samples by Using a Modified LC-ESI-MS/MS Method

“…At present, many researches have mainly focused on the detection of MA [16][17][18][19][20][21][22][23], while the simultaneous determination of MA and its isomer N-IBA in suspected drugs is rarely studied. The commonly used methods including infrared spectroscopy, colloidal gold-based immunoassays, and color tests are not suitable for the discrimination between MA and N-IBA since their poor specificity [24][25][26][27][28].…”