Extended coverage of HPV vaccination in middle-aged adults to prevent oropharyngeal cancers

Arya, Subhash C.; Agarwal, Nirmala

doi:10.4161/hv.20043

Cited by 4 publications

(5 citation statements)

References 3 publications

(1 reference statement)

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“…More than 90% of HPV-associated non-cervical cancers are also attributable to HPV 16 and 18, with HPV 16 accounting for the vast majority of cases456729. Smaller trials of the qHPV vaccine in males have demonstrated protection against genital warts and premalignant anal neoplasia74. Both in Europe and the USA, the rising incidence of OPSCC, including tonsillar and tongue base cancers, has been attributed to an epidemic of HPV infection75.…”

Section: Future Of Hpv Prophylactic Oral Cancer Vaccinesmentioning

confidence: 99%

Human papilloma virus in oral cancer

Kim

2016

J Korean Assoc Oral Maxillofac Surg

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Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV that are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer. Two HPV vaccines, quadrivalent and bivalent types that use virus-like particles (VLPs), are currently used in the medical commercial market. While the value of HPV vaccination for oral cancer prevention is still controversial, some evidence supports the possibility that HPV vaccination may be effective in reducing the incidence of oral cancer. This paper reviews HPV-related pathogenesis in cancer, covering HPV structure and classification, trends in worldwide applications of HPV vaccines, effectiveness and complications of HPV vaccination, and the relationship of HPV with oral cancer prevalence.

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Section: Future Of Hpv Prophylactic Oral Cancer Vaccinesmentioning

confidence: 99%

Human papilloma virus in oral cancer

Kim

2016

J Korean Assoc Oral Maxillofac Surg

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“…Dentists should be involved in improvement of knowledge and healthy attitudes of vaccination to prevent HPV infections and oral cancer associated with HPV (18,28). Lorenzo-Pouso et al (20) assessed 158 dental students for their knowledge of HPV and the study composed of 89 preclinical students (56.3%) and 69 clinical students (43.7%).…”

Section: Discussionmentioning

confidence: 99%

Awareness of Human Papillomavirus Vaccine Among Dental Students

Keser

Pekiner

2020

Clinical and Experimental Health Sciences

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Objective: More recently, HPV infection has been portrayed as a vital risk factor for head and neck squamous cell carcinoma (HNSCC). Dentistry students need comprehensive information about HPV to provide accurate advice to their patients. The aim of this study is 4th and 5th grade students' awareness about HPV vaccination. Methods: A questionnaire consisting of 7 questions was applied to 226 students (102 4th grade and 126 5th grades), who were studying at Marmara University Faculty of Dentistry. In this survey, students' knowledge level and awareness were examined. Results: In our study 75 (33.1%) of the participants were male and 151 (66.8%) were female. The rates of agreement of 4th grade students (96.1%) with the proposition "It is important that oral health professionals play an active role in the general medical condition of their patients." were statistically significantly lower than the 5th grade students (97.6%) (p: 0.010; p <0.05). A statistically significant difference between grades in terms of participation rates in the statement "I got my HPV vaccine / I am thinking of getting it". The rate of participation of 5th grade (38.7%) students in this statement was significantly lower than 4th grades (45.1%) (p:0.019; p<0.05) and significantly higher in women (47.7%) than in men (29.3%) (p = 0.005; p <0.05). Conclusion: Comprehensive training and motivation for improving dentistry students awareness against HPV vaccine will also improve knowledge and attitudes of the dental students on HPV induced oral cancer.

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“…The vaccination against HPV-positive OSCC, including tonsillar fossa and ventral surface of tongue carcinomas, is expected to be effective for decreasing the prevalence of oral HPV infection in middle-aged adults even though vaccine efficacy against oral HPV infections presently lacks evidence [52,53]. ) with PCR and ISH in 40% of all patients.…”

Section: History Of Hpv Vaccine and Current Scenariomentioning

confidence: 99%

“…1,2,3,4,6,7,10,11,13,16,18,30,31,32,33,35,45,52,55,57, 59, 69, 72, and 73 have been proved to be associated with benign lesions and 12 types, 2,3,6,11,13,16,18,31,33,35,52, and 57 with malignant lesions 31, 32. A total of 99% of HPV infections in HNSCC are related to high-risk types 16, 18, 31, or 33, with HPV 16 as the most common subtype and HPV 33 accounting for less than 10% of cases.…”

mentioning

confidence: 99%

Non-Smoker’s Cancer- Human Papilloma Virus (HPV) Induced Head & Neck Squamous Cell Carcinoma (HNSCC)

Ghoshal,

Singh

2023

J Clin Surg Anesth

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Head and neck squamous cell carcinoma is recognized as 6th most common cancer worldwide. Etiological factors are generally cigarettes, alcohol consumption also tobacco products such as ghutka, pan masala and betel quid also triggers the development of OSCC. Among several causes of cervical malignancies which the second most carcinoma is the world, infection with some types of human papilloma virus (HPV) is thought to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; from which more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. HPV is suspected as the principle causative factor for oral malignancy in non smoker and non-alcoholic patients. It was also reported to be associated with Head and neck squamous cell carcinoma in 1995. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV which are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer. The value of HPV vaccination for oral cancer prevention is still controversial and hypothetical; some evidence also supports the possibility that HPV vaccination may be preventive factor in reducing the incidence of oral cancer.

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Extended coverage of HPV vaccination in middle-aged adults to prevent oropharyngeal cancers

Cited by 4 publications

References 3 publications

Human papilloma virus in oral cancer

Human papilloma virus in oral cancer

Awareness of Human Papillomavirus Vaccine Among Dental Students

Non-Smoker’s Cancer- Human Papilloma Virus (HPV) Induced Head & Neck Squamous Cell Carcinoma (HNSCC)

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