Extended and functionalized porous iron(iii) tri- or dicarboxylates with MIL-100/101 topologies

Horcajada, Patricia; Chevreau, Hubert; Heurtaux, Daniela; Benyettou, Farah; Salles, Fabrice; Devic, Thomas; García-Márquez, Alfonso; Yu, Rena C.; Lavrard, Hubert; Dutson, Claire L.; Magnier, Emmanuel; Maurin, Guillaume; Elkaı̈m, Erik; Serre, Christian

doi:10.1039/c4cc02175d

Cited by 95 publications

(99 citation statements)

References 23 publications

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“…Interestingly, combining [Fe 3 (µ 3 ‐O)(COO) 6 ] SBUs and BDC linkers results in another mtn ‐type structure, MIL‐101(Fe), which is isostructural to MIL‐101(Al, Cr) . Nevertheless, MIL‐101(Fe) shows relatively low thermodynamic stability and will gradually transform into denser forms, such as MIL‐53(Fe) or MIL‐88(Fe), when exposed to strongly polar solvents …”

Section: Stable Metal–organic Frameworkmentioning

confidence: 99%

Stable Metal–Organic Frameworks: Design, Synthesis, and Applications

et al. 2018

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Metal-organic frameworks (MOFs) are an emerging class of porous materials with potential applications in gas storage, separations, catalysis, and chemical sensing. Despite numerous advantages, applications of many MOFs are ultimately limited by their stability under harsh conditions. Herein, the recent advances in the field of stable MOFs, covering the fundamental mechanisms of MOF stability, design, and synthesis of stable MOF architectures, and their latest applications are reviewed. First, key factors that affect MOF stability under certain chemical environments are introduced to guide the design of robust structures. This is followed by a short review of synthetic strategies of stable MOFs including modulated synthesis and postsynthetic modifications. Based on the fundamentals of MOF stability, stable MOFs are classified into two categories: high-valency metal-carboxylate frameworks and low-valency metal-azolate frameworks. Along this line, some representative stable MOFs are introduced, their structures are described, and their properties are briefly discussed. The expanded applications of stable MOFs in Lewis/Brønsted acid catalysis, redox catalysis, photocatalysis, electrocatalysis, gas storage, and sensing are highlighted. Overall, this review is expected to guide the design of stable MOFs by providing insights into existing structures, which could lead to the discovery and development of more advanced functional materials.

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Section: Stable Metal–organic Frameworkmentioning

confidence: 99%

Stable Metal–Organic Frameworks: Design, Synthesis, and Applications

et al. 2018

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“…Since Ferey and co-workers reported the first study of iron-based MOFs for applications in biomedicine [31], a tremendous amount of work has emerged towards developing the great potential for various applications of nanoparticulate MOFs (NMOFs) in healthcare [16,[32][33][34][35][36] Iron MOFs are probably the most widely studied materials for healthcare applications to date, because iron is well tolerated, with a 50% lethal dose (LD 50 ) of 30 gkg -1 when orally administered to rats, while their high porosity enables very high drug loadings [31,[37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

530

176

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Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

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“…A large number of strategies have been studied, but for application, drug-delivery systems must overcome issues surrounding bioavailability,7, 8 the uncontrollable release of drugs (usually due to carrier instability),9, 10, 11 loading capacities,11, 12, 13 particle size,14, 15, 16 nanoparticle cellular internalization routes,14, 17, 18 and toxicity 19, 20. The exceptional storage capacities of metal-organic frameworks (MOFs), together with their robustness and structural tailorability, have made them attractive for a wide variety of applications,21, 22 including several promising breakthroughs in biomedicine 9, 10, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33. One of their main advantages is that their cytotoxicity and properties can be tuned by the thoughtful choice of metal and linkers 20, 34, 35…”

Section: Introductionmentioning

confidence: 99%

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Lázaro

Haddad

Sacca

et al. 2017

Chem

294

158

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SummaryThe high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of surface functionality is a route to enhanced properties, and here we report on a surface-modification procedure—click modulation—that controls their size and surface chemistry. The zirconium terephthalate MOF UiO-66 is (1) synthesized as ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded with cargo, and (3) covalently surface modified with poly(ethylene glycol) (PEG) chains through mild bioconjugate reactions. At pH 7.4, the PEG chains endow the MOF with enhanced stability toward phosphates and overcome the “burst release” phenomenon by blocking interaction with the exterior of the nanoparticles, whereas at pH 5.5, stimuli-responsive drug release is achieved. The mode of cellular internalization is also tuned by nanoparticle surface chemistry, such that PEGylated UiO-66 potentially escapes lysosomal degradation through enhanced caveolae-mediated uptake. This makes it a highly promising vector, as demonstrated for dichloroacetic-acid-loaded materials, which exhibit enhanced cytotoxicity. The versatility of the click modulation protocol will allow a wide range of MOFs to be easily surface functionalized for a number of applications.

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Extended and functionalized porous iron(iii) tri- or dicarboxylates with MIL-100/101 topologies

Cited by 95 publications

References 23 publications

Stable Metal–Organic Frameworks: Design, Synthesis, and Applications

Stable Metal–Organic Frameworks: Design, Synthesis, and Applications

Application of zirconium MOFs in drug delivery and biomedicine

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

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