2022
DOI: 10.1101/2022.01.13.22269176
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ExPRSweb - An Online Repository with Polygenic Risk Scores for Common Health-related Exposures

Abstract: Complex traits are influenced by genetic risk factors, lifestyle, and environmental variables, so called exposures. Some exposures, e.g., smoking or lipid levels, have common genetic modifiers identified in genome-wide association studies. Since measurements are often unfeasible, Exposure Polygenic Risk Scores (ExPRSs) offer an alternative to study the influence of exposures on various phenotypes. Here, we collected publicly available summary statistics for 28 exposures and applied four common PRS methods to g… Show more

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