Expressions of TGF-β2, bFGF and ICAM-1 in lens epithelial cells of complicated cataract with silicone oil tamponade

Liu, Bei; Gao, Jing; Lyu, B B; Du, Shasha; Pei, Cheng; Zhu, Zhongqiao; Ma, Bo

doi:10.18240/ijo.2017.07.03

Cited by 1 publication

(1 citation statement)

References 30 publications

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“… 38 , 39 bFGF and VEGF inhibit proinflammatory cytokine-induced ECs adhesion by inhibiting the expression of ICAM-1, VCAM-1 and E-selectin. 40 The death mediator FAS ligand (FASL) is usually found in the vasculature of solid tumors, and upregulated by VEGF-A, which selectively kills effector T cells, resulting in a lack of intratumoral CD8 + T cells. 41 In addition, TECs can upregulate multiple inhibitory molecules, including galectin 1 (Gal-1) and endothelin B receptor (ETBR), creating an endothelial barrier for immune cells to infiltrate tumor tissue.…”

Section: The Vascular-immune Crosstalkmentioning

confidence: 99%

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

Jiang,

Fang,

Hong

et al. 2024

IJN

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Tumor vessels characterized by abnormal functions and structures hinder the infiltration and immune antigen presentation of immune cells by inducing the formation of an immunosuppressive microenvironment (“cold” environment). Vascular-targeted therapy has been proven to enhance immune stimulation and the effectiveness of immunotherapy by modulating the “cold” microenvironment, such as hypoxia and an acidic microenvironment. Notably, a therapeutic strategy based on “vascular-immune” crosstalk can achieve dual regulation of tumor vessels and the immune system by reprogramming the tumor microenvironment (TME), thus forming a positive feedback loop between tumor vessels and the immune microenvironment. From this perspective, we discuss the factors of tumor angiogenesis and “cold” TME formation. Building on this foundation, some vascular-targeted therapeutic drugs will be elaborated upon in detail to achieve dual regulation of tumor vessels and immunity. More importantly, we focus on cutting-edge nanotechnology in view of “vascular-immune” crosstalk and discuss the rational fabrication of tailor-made nanosystems for efficiently enhancing immunotherapy.

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Section: The Vascular-immune Crosstalkmentioning

confidence: 99%

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

Jiang,

Fang,

Hong

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Expressions of TGF-β2, bFGF and ICAM-1 in lens epithelial cells of complicated cataract with silicone oil tamponade

Abstract: The up-regulated TGF-β2, bFGF and ICAM-1 maybe associate with the occurrence and development of complicated cataract with silicone oil tamponade.

Cited by 1 publication

References 30 publications

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

Cancer Immunotherapy with “Vascular-Immune” Crosstalk as Entry Point: Associated Mechanisms, Therapeutic Drugs and Nano-Delivery Systems

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