Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions

Zhang, Yu; Zhao, Aimin; Shi, Guiying; Jin, Huifang; Lin, Qi

doi:10.1016/j.fertnstert.2007.08.009

Cited by 44 publications

(32 citation statements)

References 36 publications

(37 reference statements)

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“…In particular, Giuliani et al [82] found that maintaining a low ratio of CD16 + to CD56 + cells appears to be important for pregnancy success, likely due to the pro-inflammatory nature of CD16 + cells. Our preliminary data suggest that infection with P. gingivalis induces loss of CD56 + dNK cells and an [85,86]. There is evidence that CD56 bright cells have a crucial role in implantation, trophoblast migration, and spiral artery remodeling [64], and that these cells closely associate with dMΦ and decidual vessels in the first trimester [87,88].…”

Section: P Gingivalis As a Vascular Pathogen Of The Placental Bedmentioning

confidence: 68%

Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium considered to be an important pathogen of periodontal disease that is also implicated in adverse pregnancy outcome (APO). Until recently, our understanding of the role of P. gingivalis in APO has been limited and sometimes contradictory. The purpose of this review is to provide an overview of past and current research on P. gingivalis that addresses some of the controversies concerning the role of this organism in the pathogenesis of APO.ARTICLE HISTORY

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Section: P Gingivalis As a Vascular Pathogen Of The Placental Bedmentioning

confidence: 68%

Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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“…Could NKp46-mediated cytolytic function of dNK be exerted in some pathologic conditions of pregnancy, including recurrent spontaneous abortion (36), or uterine viral infection (37)? Prevention of uterine infection is critical to the establishment of human pregnancy and appropriate fetal development.…”

Section: Discussionmentioning

confidence: 99%

Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy

Costa

Casemayou

Aguerre-Girr

et al. 2008

The Journal of Immunology

128

150

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In early human pregnancy, uterine decidual NK cells (dNK) are abundant and considered as cytokine producers but poorly cytotoxic despite their cytolytic granule content, suggesting a negative control of this latter effector function. To investigate the basis of this control, we examined the relative contribution to the cytotoxic function of different activating receptors expressed by dNK. Using a multicolor flow cytometry analysis, we found that freshly isolated dNK exhibit a unique repertoire of activating and inhibitory receptors, identical among all the donors tested. We then demonstrated that in fresh dNK, mAb-specific engagement of NKp46-, and to a lesser extent NKG2C-, but not NKp30-activating receptors induced intracellular calcium mobilization, perforin polarization, granule exocytosis and efficient target cell lysis. NKp46-mediated cytotoxicity is coactivated by CD2 but dramatically blocked by NKG2A coengagement, indicating that the dNK cytotoxic potential could be tightly controlled in vivo. We finally found that in dNK, mAb-specific engagement of NKp30, but not NKp46, triggered the production of IFN-γ, TNF-α, MIP-1α, MIP-1β, and GM-CSF proinflammatory molecules. These data demonstrate a differential, controlled role of NKp46- and NKp30-activating receptors expressed by dNK that could be critical for the outcome of pregnancy and the killing of uterine cells infected by pathogens.

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“…In addition, dNK cells are characterized by differential expression of a large set of genes, including genes encoding tetraspanins, integrin subunits, and galectins [12]. However, there are also studies where a CD56 dim CD16 þ population of dNK cells has been noted, including in association with pregnancy failure [10,13,14], but it is not clear if this population is different from pNK cells.…”

Section: Introductionmentioning

confidence: 99%

Immunophenotype and Cytokine Profiles of Rhesus Monkey CD56bright and CD56dim Decidual Natural Killer Cells1

Dambaeva¹,

Durning²,

Rozner³

et al. 2012

Biology of Reproduction

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The primate endometrium is characterized in pregnancy by a tissue-specific population of CD56(bright) natural killer (NK) cells. These cells are observed in human, rhesus, and other nonhuman primate decidua. However, other subsets of NK cells are present in the decidua and may play distinct roles in pregnancy. The purpose of this study was to define the surface marker phenotype of rhesus monkey decidual NK (dNK) cell subsets, and to address functional differences by profiling cytokine and chemokine secretion in contrast with decidual T cells and macrophages. Rhesus monkey decidual leukocytes were obtained from early pregnancy tissues, and were characterized by flow cytometry and multiplex assay of secreted factors. We concluded that the major NK cell population in rhesus early pregnancy decidua are CD56(bright) CD16(+)NKp30(-) decidual NK cells, with minor CD56(dim) and CD56(neg) dNK cells. Intracellular cytokine staining demonstrated that CD56(dim) and not CD56(bright) dNK cells are the primary interferon-gamma (IFNG) producers. In addition, the profile of other cytokines, chemokines, and growth factors secreted by these two dNK cell populations was generally similar, but distinct from that of peripheral blood NK cells. Finally, analysis of multiple pregnancies from eight dams revealed that the decidual immune cell profile is characteristic of an individual animal and is consistently maintained across successive pregnancies, suggesting that the uterine immune environment in pregnancy is carefully regulated in the rhesus monkey decidua.

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Expressions of natural cytotoxicity receptors and NKG2D on decidual natural killer cells in patients having spontaneous abortions

Cited by 44 publications

References 36 publications

Porphyromonas gingivalisand adverse pregnancy outcome

Porphyromonas gingivalisand adverse pregnancy outcome

Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy

Immunophenotype and Cytokine Profiles of Rhesus Monkey CD56bright and CD56dim Decidual Natural Killer Cells1

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