Expressions of a 68kDa-Glycoprotein (GP68) and Laminin in the Mesodermal Tissue of the Developing Mouse Embryo

Morita, Toshiyuki; Shinozawa, Takao; Nakamura, Miyuki; Awaya, Akira; Sato, Noriaki; Ishiwata, Isamu; Kami, Koji

doi:10.2535/ofaj1936.75.4_185

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…This subepicardium is a hydrated ECM, rich in proteins, including collagens I, IV, V, and VI and fibronectin (Tidball, 1992;Hurlé et al, 1994;Ká lmá n et al, 1995;Bouchey et al, 1996;Kim et al, 1999), flectin (Tsuda et al, 1998), fibulin-2 (Tsuda et al, 2001), GP68 (Morita et al, 1998), laminin and proteoglycans (Ká lmá n et al, 1995), vitronectin, fibrillin-2, elastin (Bouchey et al, 1996), and tenascin-X (Burch et al, 1995). It has been shown that both the epicardium and myocardium contribute proteins to this matrix (Bouchey et al, 1996).…”

Section: The Subepicardial Extracellular Environmentmentioning

confidence: 99%

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

2003

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After its initial formation the epicardium forms the outermost cell layer of the heart. As a result of an epithelial-to-mesenchymal transformation (EMT) individual cells delaminate from this primitive epicardial epithelium and migrate into the subepicardial space (Pérez-Pomares et al., Dev Dyn 1997; 210: 96 -105; Histochem J 1998a;30:627-634 Dev. Biol. 2002b;247:307-326). A subset of EPDCs continue to differentiate in a variety of different cell types (including coronary endothelium, coronary smooth muscle cells (CoSMCs), interstitial fibroblasts, and atrioventricular cushion mesenchymal cells), whereas other EPDCs remain in a more or less undifferentiated state. Based on its specific characteristics, we consider the EPDC as the ultimate 'cardiac stem cell'. In this review we briefly summarize what is known about events that relate to EPDC development and differentiation while at the same time identifying some of the directions where EPDCrelated research might lead us in the near future. Anat Rec Part A 276A: 43-57, 2004.

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Section: The Subepicardial Extracellular Environmentmentioning

confidence: 99%

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

2003

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“…This matrix has been shown to contain fibronectin and collagens I, IV, V, VI [Tidball, 1992;Hurlé et al, 1994;Ká lmá n et al, 1995;Bouchey et al, 1996;Kim et al, 1999], proteoglycans and laminin [Ká lmá n et al, 1995], GP68 [Morita et al, 1998], vitronectin, fibrillin-2, elastin [Bouchey et al, 1996], tenascin-X [Burch et al, 1995] and flectin [Tsuda et al, 1998]. Virá gh et al [1993] speculated that the myocardium of the AV region might secrete substances into the subepicardial matrix of the AV groove similar to those secreted into the matrix of the endocardial AV cushions.…”

Section: Formation Of the Epicardium And Subepicardial Spacementioning

confidence: 99%

The Origin, Formation and Developmental Significance of the Epicardium: A Review

Männer

Pérez‐Pomares

Macías

et al. 2001

Cells Tissues Organs

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Questions on the embryonic origin and developmental significance of the epicardium did not receive much recognition for more than a century. It was generally thought that the epicardium was derived from the outermost layer of the primitive myocardium of the early embryonic heart tube. During the past few years, however, there has been an increasing interest in the development of the epicardium. This was caused by a series of new embryological data. The first data showed that the epicardium did not derive from the primitive myocardium but from a primarily extracardiac primordium, called the proepicardial serosa. Subsequent data then suggested that the proepicardial serosa and the newly formed epicardium provided nearly all cellular elements of the subepicardial and intermyocardial connective tissue, and of the coronary vasculature. Recent data even suggest important modulatory roles of the epicardium and of other proepicardium-derived cells in the differentiation of the embryonic myocardium and cardiac conduction system. The present paper reviews our current knowledge on the origin and embryonic development of the epicardium.

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