Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration

Lee, In Se; Nam, You Seon; Lee, Choong Hyun; Chung, Dawn; Yoon, Yeo Sung; Kim, Jin Sang; Yi, Seong Joon; Pai, Tongkun; Lee, Heungshik S.

doi:10.3177/jnsv.50.144

Cited by 6 publications

(5 citation statements)

References 23 publications

(33 reference statements)

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“…The reduced NPY immunoreactivity in the LH and PVN, but not the ARC, after treatment with PD-type saponins supported a result that was similar to our previous study ; that is, PD-type saponins may inhibit the release of NPY or its transport to the PVN, rather than NPY synthesis in the ARC. Lee et al (2004) have reported the anorexic effect of capsaicin for the treatment of the obesity-related neurotransmitters/neuromodulators, NPY and CCK. There was a significantly lower NPY immunoreactivity in the ARC and PVN of the capsaicintreated rats compared with the control rats.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the antiobesity effects of the protopanaxadiol‐ and protopanaxatriol‐type saponins of red ginseng

Kim

Kang

Han

et al. 2008

Phytotherapy Research

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A previous study demonstrated that ginseng crude saponins prevent obesity induced by a high-fat diet in rats. Ginseng crude saponins are known to contain a variety of bioactive saponins. The present study investigated and compared the antiobesity activity of protopanaxadiol (PD) and protopanaxatriol (PT) type saponins, major active compounds isolated from crude saponins. Male 4-week-old Sprague-Dawley rats were fed with normal diet (N) or high-fat diet (HF). After 5 weeks, the HF diet group was subdivided into the control HF diet, HF diet-PD and HF diet-PT group (50 mg/kg/day, 3 weeks, i.p.). Treatment with PD and PT in the HF diet group reduced the body weight, total food intake, fat contents, serum total cholesterol and leptin to levels equal to or below the N diet group. The hypothalamic expression of orexigenic neuropeptide Y was significantly decreased with PD or PT treatment, whereas that of anorexigenic cholecystokinin was increased, compared with the control HF diet group. In addition, PD type saponins had more potent antiobesity properties than PT saponins, indicating that PD-type saponins are the major components contributing to the antiobesity activities of ginseng crude saponins. The results suggest that the antiobesity activity of PD and PT type saponins may result from inhibiting energy gain, normalizing hypothalamic neuropeptides and serum biochemicals related to the control of obesity.

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Section: Discussionmentioning

confidence: 99%

Comparison of the antiobesity effects of the protopanaxadiol‐ and protopanaxatriol‐type saponins of red ginseng

Kim

Kang

Han

et al. 2008

Phytotherapy Research

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“…Lee et al (20) found a significantly lower concentration of NPY-immunopositive cells in the arcuate and paraventricular nuclei in capsaicin-treated rats. Therefore, it is plausible that increased response to high-dose GLP-1 is mediated by a shift in the balance between orexogenic and anorexogenic hypothalamic peptide expression.…”

Section: Table 2 Numbers Of C-fos-immunoreactive Neuronal Nuclei In mentioning

confidence: 99%

Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms

Zhang

Ritter

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Zhang J, Ritter RC. Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms. Am J Physiol Regul Integr Comp Physiol 302: R264 -R273, 2012. First published October 26, 2011 doi:10.1152/ajpregu.00114.2011.-Previous reports suggest that glucagon-like peptide (GLP-1), a peptide secreted from the distal small intestine, is an endocrine satiation signal. Nevertheless, there are conflicting reports regarding the site where circulating GLP-1 acts to reduce food intake. To test the hypothesis that vagal afferents are necessary for reduction of food intake by circulating GLP-1, we measured intake of 15% sucrose during intravenous GLP-1 infusion in intact, vagotomized, and capsaicin-treated rats. We also measured sucrose intake during intravenous infusion of cholecystokinin, a peptide known to reduce food intake via abdominal vagal afferents. We found that reduction of intake by GLP-1 was not diminished by capsaicin treatment or vagotomy. In fact, reduction of sucrose intake by our highest GLP-1 dose was enhanced in vagotomized and capsaicin-treated rats. Intravenous GLP-1 induced comparable increases of hindbrain c-Fos immunoreactivity in intact, capsaicin-treated, and vagotomized rats. Plasma concentrations of active GLP-1 in capsaicin-treated rats did not differ from those of controls during the intravenous infusions. Finally, capsaicin treatment was not associated with altered GLP-1R mRNA in the brain, but nodose ganglia GLP-1R mRNA was significantly reduced in capsaicin-treated rats. Although reduction of food intake by intraperitoneal cholecystokinin was abolished in vagotomized and capsaicin-treated rats, reduction of intake by intravenous cholecystokinin was only partially attenuated. These results indicate that vagal or capsaicin-sensitive neurons are not necessary for reduction of food intake by circulating (endocrine) GLP-1, or cholecystokinin. Vagal participation in satiation by these peptides may be limited to paracrine effects exerted near the sites of their secretion.

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“…A previous study showed that the administration of capsaicin decreased the expression of neuropeptide Y (NPY) and increased the expression of cholecystokinin in the rat hypothalamus [17]. They suggested that capsaicin may function to control food intake and obesity.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration

Lee

Choi

Hwang

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Capsaicin has effects on the adiposity by increasing energy and lipid metabolism, and decreases appetite and fat intake. In the present study, we investigated changes in food intake and body weight after capsaicin treatment. We also observed changes in orexigenic and anorexigenic neuropeptides-agouti-related peptide (AgRP), -melanocyte-stimulating hormone (-MSH), adrenocorticotropic hormone (ACTH) and orexin-immunoreactivities in the rat hypothalamus after capsaicin administration. Only one day after capsaicin treatment, the mean food intake was significantly decreased. There was no significant difference in the mean body weight between vehicle-and capsaicin-treated groups. In addition, after capsaicin treatment, numbers of AgRP-and orexin-immunoreactive ( + ) cells were significantly decreased in the arcuate nucleus (ARC) and lateral hypothalamic area, respectively. In contrast, the number of -MSH + and ACTH + cells in the ARC of the capsaicin-treated rats was higher than in the vehicle-treated rats. These results indicate that capsaicin reduces food intake, not body weight, transiently, and decreases AgRP and orexin immunoreactivities, whereas it increases -MSH and ACTH immunoreactivities in rat hypothalamic nuclei. Capsaicin is a major pungent ingredient present in a variety of capsicum fruits, such as red peppers [34]. Since its initial identification in 1919, numerous pharmacological effects of capsaicin have been investigated and reported [20,34,39]. It has been known that capsaicin reduces adiposity by increasing energy and lipid metabolism in rats and decreases appetite and fat intake in humans [15,39]. It was recently reported that the capsaicin receptor, vanilloid receptor subtype 1 (VR1), was found throughout the central nervous system, including the hypothalamic nuclei [19,33].Many researchers have focused on specific neuropeptides, neurotransmitters, receptors and neuronal circuits that both neuroanatomically and neurophysiologically control food intake in the central nervous system [4,31,32]. The hypothalamus is thought to be a major center for controlling feeding behavior in the brain [10]. In many hypothalamic nuclei, the arcuate nucleus (ARC) and the lateral hypothalamic area (LH) are regarded as important centers for regulating food intake and energy homeostasis [4,10]. In the hypothalamus, many neuropeptides, such as neuropeptide Y, orexin, agouti-related peptid and proopiomelanocortin, are known to participate in regulating food intake [10].Agouti-related peptide (AgRP) is expressed only in the ARC of the hypothalamus and that AgRP-containing neurons project to various hypothalamic nuclei, such as the paraventricular nucleus and LH [7]. AgRP is known to be a potent stimulant of food intake and to be involved in the maintenance of feeding behavior [37].On the other hand, it has been reported that AgRP is an endogenous antagonist of melanocortin receptor (subtype 4) (MC4-R), which functions to control food intake and energy homeostasis in the hypothalamus [9,12]. Proopiomelanocort...

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Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration

Cited by 6 publications

References 23 publications

Comparison of the antiobesity effects of the protopanaxadiol‐ and protopanaxatriol‐type saponins of red ginseng

Comparison of the antiobesity effects of the protopanaxadiol‐ and protopanaxatriol‐type saponins of red ginseng

Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms

Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration

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