Expression, Subcellular Localization, and Regulation of Sigma Receptor in Retinal Müller Cells

Jia, Guanghong; Mysona, Barbara A.; Dun, Ying; Gnana-Prakasam, Jaya P.; Pabla, Navjotsingh; Li, Weiguo; Zheng, Dezhi; Ganapathy, Vadivel; Smith, Sylvia B.

doi:10.1167/iovs.06-0608

Cited by 60 publications

(65 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Primary RPE (mRPE) and Müller cells were isolated from wild-type, Slc5a8 À/À , and Gpr109a À/À mouse eyes and cultured in accordance with our previously described protocols. 27,28 Assay of System x c À Transport Activity…”

Section: Animals and Cell Culturementioning

confidence: 99%

Induction of the Cystine/Glutamate Exchanger SLC7A11 in Retinal Pigment Epithelial Cells by the Antipsoriatic Drug Monomethylfumarate

Ananth

Babu²,

Veeranan-Karmegam

et al. 2013

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Section: Animals and Cell Culturementioning

confidence: 99%

Induction of the Cystine/Glutamate Exchanger SLC7A11 in Retinal Pigment Epithelial Cells by the Antipsoriatic Drug Monomethylfumarate

Ananth

Babu²,

Veeranan-Karmegam

et al. 2013

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

“…The intracellular localization of sigma-1 receptors (mainly in endoplasmatic reticulum, but also in nuclear and plasma membranes and on mitochondria [52,57,102,133,137]) suggests that these binding sites could be involved in the regulation of calcium mobilization.…”

Section: Modulation Of Calcium Homeostasismentioning

confidence: 99%

The cholinergic system, sigma-1 receptors and cognition

Waarde

Ramakrishnan

Rybczynska

et al. 2011

Behavioural Brain Research

View full text Add to dashboard Cite

a b s t r a c tThis article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive disorders. Sigma-1 receptors, initially considered as a subtype of the opioid family, are unique ligand-regulated molecular chaperones in the endoplasmatic reticulum playing a modulatory role in intracellular calcium signaling and in the activity of several neurotransmitter systems, particularly the cholinergic and glutamatergic pathways. Several central nervous system (CNS) drugs show high to moderate affinities for sigma-1 receptors, including acetylcholinesterase inhibitors (donepezil), antipsychotics (haloperidol, rimcazole), selective serotonin reuptake inhibitors (fluvoxamine, sertraline) and monoamine oxidase inhibitors (clorgyline). These compounds can influence cognitive functions both via their primary targets and by activating sigma-1 receptors in the CNS. Sigma-1 agonists show powerful anti-amnesic and neuroprotective effects in a large variety of animal models of cognitive dysfunction involving, among others (i) pharmacologic target blockade (with muscarinic or NMDA receptor antagonists or p-chloroamphetamine); (ii) selective lesioning of cholinergic neurons; (iii) CNS administration of ␤-amyloid peptides; (iv) aging-induced memory loss, both in normal and senescentaccelerated rodents; (v) neurodegeneration induced by toxic compounds (CO, trimethyltin, cocaine), and (vi) prenatal restraint stress.

show abstract

“…16 We localized R1 to the ER and nuclear membranes of retinal Müller glial cells. 17 The ER is the entry site for proteins into the secretory pathway. Proteins are translocated into the ER lumen in an unfolded state and require protein chaperones and catalysts of protein folding to attain their final appropriate conformation.…”

mentioning

confidence: 99%

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons

Ha¹,

Dun²,

Thangaraju³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

Expression, Subcellular Localization, and Regulation of Sigma Receptor in Retinal Müller Cells

Abstract: MCs express sigmaR1 and demonstrate robust sigmaR1 binding activity, which is inhibited by sigmaR1 ligands and is stimulated during oxidative stress. The potential of Müller cells to bind sigmaR1 ligands may prove beneficial in retinal degenerative diseases such as diabetic retinopathy.

Cited by 60 publications

References 42 publications

Induction of the Cystine/Glutamate Exchanger SLC7A11 in Retinal Pigment Epithelial Cells by the Antipsoriatic Drug Monomethylfumarate

Induction of the Cystine/Glutamate Exchanger SLC7A11 in Retinal Pigment Epithelial Cells by the Antipsoriatic Drug Monomethylfumarate

The cholinergic system, sigma-1 receptors and cognition

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons

Contact Info

Product

Resources

About