Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone‐secreting carcinoma

Mulla, Abeda; Christian, Helen; Solito, Egle; Mendoza, Nigel; Morris, John F.; Buckingham, Julia C.

doi:10.1111/j.1365-2265.2004.01936.x

Cited by 50 publications

(39 citation statements)

References 58 publications

(127 reference statements)

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“…Evidence for this lies in the clear observations that its expression is in a tumor-specific manner. It has been reported that annexin A1 is up-regulated in hepatocellular carcinoma (de Coupade et al, 2000), bladder cancer (Cui et al, 2007), larynx cancer (Silistino-Souza et al, 2007), human breast cancer (Kang et al, 2012) and pituitary adenoma (Mulla et al, 2004), while it is absent or down-regulated in human esophageal squamous cell carcinoma (Liu et al, 2003), oral squamous-cell carcinoma (Nomura et al, 2009), prostate cancers (Silistino-Souza et al, 2007) head and neck cancers (Garcia Pedrero et al, 2004), intestinal-type sinonasal adenocarcinoma (Rodrigo et al, 2011), B-cell non-Hodgkin's lymphomas (Vishwanatha et al, 2004), thyroid cancers (Petrella et al, 2006) and endometrial carcinoma (Da et al, 2001). In our study, we found that annexin A1 was significantly overexpressed in PDAC tissues by real-time RT-PCR, Western blot and immunohistochemistry, which was consistent with the early study of annexin A1 expression in pancreatic cancer (Bai et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Chen¹,

Shen²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Annexin A1 is a 37-kDa calcium-and phospholipid-binding protein of the annexin superfamily considered to play an important role in tumorigenesis. However, associations with clinicopathological features in pancreatic ductal adenocarcinoma (PDAC) cases have yet to be fully defined. We therefore investigated the prognostic value of annexin A1 protein as a PDAC biomarker in 83 tumor and matched non-cancerous tissues or normal pancreas tissues. Expression was analyzed using real-time RT-PCR, Western blotting and immunohistochemistry. In non-tumor tissue, myoepithelial cells showed no or weak expression of annexin A1 while expression was strong and sometimes even located in the nuclei of endothelial cells in tumor tissue. High expression was significantly associated with advanced stage (P <0.05) and a worse overall survival (P <0.05). These results provide new insights to better understand the role of annexin A1 in PDAC survival, and might be relevant to prediction of prognosis and development of more effective therapeutic strategies aimed at improving survival.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Chen¹,

Shen²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…To date, there are some contradictory descriptions on annexin I expression in human cancers. It has been reported that annexin I is up-regulated in human breast cancer [17] , hepatocellular carcinoma [18] , and pituitary adenoma [19] and down-regulated in human esophageal squamous cell carcinoma [20] , prostate cancer [21] , and endometrial carcinoma [22] . In this study, we found that annexin I was significantly overexpressed in pancreatic cancer by Western blot and immunohistochemistry, which was consistent with the results of gene expression profile analysis.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of annexin 1 in pancreatic cancer and its clinical significance

Bai

Ni²,

Zhao³

et al. 2004

WJG

147

115

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“…Overexpression of annexins has been reported in various carcinomas, and is thought to be associated with cell proliferation, differentiation and cell-cell adhesion in the pathogenesis of carcinoma [60][61][62][63]. However, the functions of annexins have not been fully elucidated.…”

Section: Proteins Involved In Cell Regulationmentioning

confidence: 99%

Searching for potential biomarkers of cisplatin resistance in human ovarian cancer using a label‐free LC/MS‐based protein quantification method

Fitzpatrick

You²,

Bemis³

et al. 2007

Proteomics Clinical Apps

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Platinum-based chemotherapy, such as cisplatin, is the primary treatment for ovarian cancer. However, drug resistance has become a major impediment to the successful treatment of ovarian cancer. To date, the molecular mechanisms of resistance to platinum-based chemotherapy remain unclear. In this study, we applied an LC/MS-based protein quantification method to examine the global protein expression of two pairs of ovarian cancer cell lines, A2780/A2780-CP (cisplatin-sensitive/cisplatin-resistant) and 2008/2008-C13*5.25 (cisplatin-sensitive/cisplatinresistant). We identified and quantified over 2000 proteins from these cell lines and 760 proteins showed significant expression changes with a false discovery rate of less than 5% between paired groups. Based on the results we obtained, we suggest several potential pathways that may be involved in cisplatin resistance in human ovarian cancer. This study provides not only a new proteomic platform for large-scale quantitative protein analysis, but also important information for discovery of potential biomarkers of cisplatin resistance in ovarian cancer. Furthermore, these results may be clinically relevant for diagnostics, prognostics, and therapeutic improvement for ovarian cancer treatment.

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Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone‐secreting carcinoma

Abstract: The results demonstrate expression of both ANXA1 and ANXA5 in human pituitary tumours and thus raise the possibility that these proteins influence the growth and/or functional activity of the tumours.

Cited by 50 publications

References 58 publications

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Overexpression of annexin 1 in pancreatic cancer and its clinical significance

Searching for potential biomarkers of cisplatin resistance in human ovarian cancer using a label‐free LC/MS‐based protein quantification method

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