Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancer

Tsai, Hsiao Wen; Li, Chia-Jung; Lin, Lie Chwen; Chiang, An‐Jen; Chen, San-Nung; Wen, Zhi‐Hong; Tsui, Kuan‐Hao

doi:10.18632/aging.204050

Cited by 8 publications

(9 citation statements)

References 38 publications

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“…Recently, a high level of OPA3 protein has been reported in ovarian cancer tissues and cells [ 111 ]. The OPA3 gene was first identified in patients with optic neuropathy, and encodes for an OPA3 protein that is a mitochondrial protein involved in the shape and structure of the mitochondria [ 112 ].…”

Section: Mitochondrial Dynamics In Ovarian Cancermentioning

confidence: 99%

“…The OPA3 gene was first identified in patients with optic neuropathy, and encodes for an OPA3 protein that is a mitochondrial protein involved in the shape and structure of the mitochondria [ 112 ]. The high expression of OPA3 mRNA and protein levels in OC are associated with poor prognosis [ 111 ]. Importantly, it was reported that OPA3 inactivation increased sensitivity of ovarian cancer cells to PFI-1 and WZ4003 antiproliferative drugs [ 111 ].…”

Section: Mitochondrial Dynamics In Ovarian Cancermentioning

confidence: 99%

“…The high expression of OPA3 mRNA and protein levels in OC are associated with poor prognosis [ 111 ]. Importantly, it was reported that OPA3 inactivation increased sensitivity of ovarian cancer cells to PFI-1 and WZ4003 antiproliferative drugs [ 111 ].…”

Section: Mitochondrial Dynamics In Ovarian Cancermentioning

confidence: 99%

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Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Rasmo

Cormio

et al. 2023

IJMS

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Ovarian cancer (OC) represents the main cause of death from gynecological malignancies in western countries. Altered cellular and mitochondrial metabolism are considered hallmarks in cancer disease. Several mitochondrial aspects have been found altered in OC, such as the oxidative phosphorylation system, oxidative stress and mitochondrial dynamics. Mitochondrial dynamics includes cristae remodeling, fusion, and fission processes forming a dynamic mitochondrial network. Alteration of mitochondrial dynamics is associated with metabolic change in tumour development and, in particular, the mitochondrial shaping proteins appear also to be responsible for the chemosensitivity and/or chemoresistance in OC. In this review a focus on the mitochondrial dynamics in OC cells is presented.

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Section: Mitochondrial Dynamics In Ovarian Cancermentioning

confidence: 99%

Section: Mitochondrial Dynamics In Ovarian Cancermentioning

confidence: 99%

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Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Rasmo

Cormio

et al. 2023

IJMS

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“…The TMA slides consisted of samples of human gastric cancer, metastatic cancer, and normal tissues. To conduct immunocytochemistry (ICC) on the TMA slides, we followed the protocol described in a previous study [32,33]. A uorescent multiplex staining kit (BioTnA, TATS01F, Kaohsiung, Taiwan) along with speci c antibodies are utilized in labeling and detecting desired proteins in tissue samples for ICC.…”

Section: Human Stad Tissue Microarrays and Immunocytochemistry Analysismentioning

confidence: 99%

Spatial and Single-Cell Analyses Reveal Correlation between Histone H2A Dioxygenase Gene Expression and Tumor-Associated Macrophages in Gastric Cancer

Chang

Tsui

Tzeng

et al. 2023

Preprint

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Background ALKBH1 is an important enzyme involved in various cellular processes that regulates RNA demethylation in humans. While its contribution to tumor progression is known, its role in gastric cancer remains unclear. Further research is needed to explore the potential of ALKBH1 in clinicopathology, tumor immune microenvironment, and precision oncology for STAD. Methods This study used a multi-omics approach to identify ALKBH1 as an independent diagnostic biomarker for STAD with a correlation to advanced clinical status and poor overall survival rate. We analyzed publicly available datasets from GEO and TCGA, identifying differentially expressed genes in STAD and examined their relationship with immune gene expression, overall survival, tumor stage, gene mutation status, and infiltrating immune cells. We also explored ALKBH1 gene expression in different regions of the STAD using spatial transcriptomics. In addition, we utilized spatial transcriptomic and single-cell RNA-sequencing methods to investigate the correlation between PGAM1 and immune cells. We further confirmed our results by analyzing 60 STAD patient samples and examining the relationship between ALKBH1 expression, clinicopathological features, and prognosis using immunohistochemistry and bioinformatics. Results Our study revealed the expression of key gene regulators in gastric cancer that were associated with genetic variations, deletions, and the tumor microenvironment. Mutations in these regulators were positively linked to distinct immune cells in six immune datasets and played a vital role in immune cell infiltration in STAD. We found that high ALKBH1 expression was associated with macrophage infiltration in STAD. Moreover, pharmacogenomic analysis of renal cancer cell lines indicated that ALKBH1 inactivation was correlated with increased sensitivity to specific small-molecule drugs. Conclusion To sum up, the study indicates that alterations in ALKBH1 may play a role in STAD advancement and reveal new diagnostic and prognostic implications of ALKBH1 in STAD. It emphasizes the importance of ALKBH1 in the tumor immune microenvironment, implying its potential utility as a precision medicine tool and for drug screening in STAD.

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“…Ovarian cancer is among the most lethal gynaecological malignancies [ 1 ]. It involves a heterogeneous group of malignancies that differ in aetiology, molecular biology, and many other characteristics [ 2 , 3 ]. Approximately, 90% of ovarian cancers are of epithelial origin, and the prevalent subtype of epithelial ovarian cancer is serous carcinoma [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

KLHL14: A Novel Prognostic Biomarker and Therapeutic Target for Ovarian Cancer

Wang

Sun

Xia

et al. 2022

Journal of Oncology

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Ovarian cancer (OV) is a gynaecological malignancy that poses a serious risk to the health status of women. To date, effective molecular markers are unavailable for the diagnosis and management of ovarian malignancies. In this study, we aimed to investigate the molecular markers associated with the development of this cancer. We used bioinformatic analysis to determine the molecules and genes related to ovarian cancer using the gene expression profiling interactive analysis (GEPIA) and the cancer genome Atlas (TCGA) databases. In addition, we examined the genes and mechanisms underlying ovarian cancer. Our results showed that the KLHL14 gene is overexpressed in some cancers. An increase in the KLHL14 expression indicates a poor prognosis in patients with ovarian cancer. Results of immune cell infiltration analysis and half-maximal inhibitory concentration (IC50) analysis provide novel insights into the treatment of ovarian cancer. KLHL14 is anticipated to emerge as a novel molecular marker specifically for ovarian carcinoma.

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Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancer

Cited by 8 publications

References 38 publications

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Spatial and Single-Cell Analyses Reveal Correlation between Histone H2A Dioxygenase Gene Expression and Tumor-Associated Macrophages in Gastric Cancer

KLHL14: A Novel Prognostic Biomarker and Therapeutic Target for Ovarian Cancer

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