Expression Signature of the Mouse Prostate

Berquin, Isabelle M.; Min, You-Nong; Wu, Rongpei; Wu, Hanzhi; Chen, Y.Q.

doi:10.1016/s0022-5347(06)00429-0

Cited by 36 publications

(43 citation statements)

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“…The expression pattern of GRP78 and clusterin were validated by immuno-blots [17]. The mRNA abundances of prostatic proteins in each lobe of mice or rats have been investigated by Fujimoto et al and Berquin et al using PCR and microarray, respectively [38][39][40]. Our results not only agreed with theirs but also extended to more lobe specific proteins.…”

Section: Molecular Changes In Prostate Carcinogenesis In Tramp Modelsupporting

confidence: 85%

Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model

Zhang¹,

Wang²,

Zhang³

et al. 2013

Carcinogenesis

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Section: Molecular Changes In Prostate Carcinogenesis In Tramp Modelsupporting

confidence: 85%

Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model

Zhang¹,

Wang²,

Zhang³

et al. 2013

Carcinogenesis

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“…Both are expressed strongly in the prostate buds, and their expression continues through development and into adulthood (29). Foxa1 and Hoxb13 are expressed highest in the ventral lobes, at a lower level in the dorsal and lateral lobes, and weakest in the anterior lobes (9,10,29,43). During prostate carcinogenesis in the human and mouse, studies suggest that expression of both genes is maintained (31,44,45).…”

Section: Discussionmentioning

confidence: 99%

A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland

McMullin

Dobi

Mutton

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the prostate persists unabated under conditions of androgen deprivation and throughout the course of disease progression in a mouse prostate cancer model. To elucidate the molecular basis of prostate-restricted transcriptional activation of Hoxb13, a bacterial artificial chromosome (BAC)-based reporter gene deletion analysis was performed in transgenic mice. Two regions downstream of the Hoxb13 coding region were found to be required to support transcriptional activity in the prostate but were completely dispensable for expression in the colon and rectum. Bioinformatic analyses of one region identified a 37-bp element conserved in mammals. This element, which bears two potential binding sites for Forkhead class transcription factors, is occupied by FOXA1 in a human prostate cancer cell line. Precise replacement of this enhancer with an extended LoxP site in the context of a 218,555-bp BAC reporter nearly extinguished Hoxb13-mediated transcriptional activity in the mouse prostate. These data demonstrate that FOXA1 directly regulates HOXB13 in human prostate epithelial cells, and show that this prostate-specific regulatory mechanism is conserved in mice.androgen independent | recombineering | prostate-specific | Homeobox | Forkhead

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“…Although it is sometimes asserted that the mouse dorsolateral lobe is most analogous to the human peripheral zone, particularly with respect to prostate cancer, there is no consensus agreement among pathologists to support this conclusion ). However, analyses of gene expression profiling data support the idea that the dorsolateral lobe is most similar to the peripheral zone of the human prostate (Berquin et al 2005).…”

Section: Anatomy and Histologymentioning

confidence: 97%

Molecular genetics of prostate cancer: new prospects for old challenges

Shen¹,

2010

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Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Since early studies on the role of the androgen receptor that led to the advent of androgen deprivation therapy in the 1940s, there has long been intensive interest in the basic mechanisms underlying prostate cancer initiation and progression, as well as the potential to target these processes for therapeutic intervention. Here, we present an overview of major themes in prostate cancer research, focusing on current knowledge of principal events in cancer initiation and progression. We discuss recent advances, including new insights into the mechanisms of castration resistance, identification of stem cells and tumor-initiating cells, and development of mouse models for preclinical evaluation of novel therapuetics. Overall, we highlight the tremendous research progress made in recent years, and underscore the challenges that lie ahead.

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Expression Signature of the Mouse Prostate

Cited by 36 publications

References 0 publications

Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model

Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model

A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland

Molecular genetics of prostate cancer: new prospects for old challenges

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