Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1

Dunham, Daniel; Viswanathan, Prasanth; Gill, Jackson; Manzano, Mark

doi:10.1128/jvi.01360-22

Cited by 1 publication

(4 citation statements)

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“…S63845 was also tested against KHSV [182]. As previously mentioned, this virus is associated with PEL, an aggressive B-cell cancer.…”

Section: Agent(s)mentioning

confidence: 99%

“…As previously mentioned, this virus is associated with PEL, an aggressive B-cell cancer. This disease is characterized by very poor survival accompanying the high resistance to conventional chemotherapeutic treatments [120], which has motivated scientists to search for more effective antioncogenic agents [182]. Dunham et al [182] revealed that S63845 induced apoptosis in KHSV-positive as well as KHSV-and EBV-positive cells, BC3 and BC1, respectively.…”

Section: Agent(s)mentioning

confidence: 99%

“…This disease is characterized by very poor survival accompanying the high resistance to conventional chemotherapeutic treatments [120], which has motivated scientists to search for more effective antioncogenic agents [182]. Dunham et al [182] revealed that S63845 induced apoptosis in KHSV-positive as well as KHSV-and EBV-positive cells, BC3 and BC1, respectively. Interestingly, these cell lines turned out to be resistant to inhibitors targeting either BCL-2 or BCL-XL, indicating the main role of MCL-1 in maintaining the viability of virus-infected PEL cells [182].…”

Section: Agent(s)mentioning

confidence: 99%

“…Dunham et al [182] revealed that S63845 induced apoptosis in KHSV-positive as well as KHSV-and EBV-positive cells, BC3 and BC1, respectively. Interestingly, these cell lines turned out to be resistant to inhibitors targeting either BCL-2 or BCL-XL, indicating the main role of MCL-1 in maintaining the viability of virus-infected PEL cells [182].…”

Section: Agent(s)mentioning

confidence: 99%

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Mcl-1 Protein and Viral Infections: A Narrative Review

Wyżewski,

Stępkowska,

Kobylińska

et al. 2024

IJMS

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MCL-1 is the prosurvival member of the Bcl-2 family. It prevents the induction of mitochondria-dependent apoptosis. The molecular mechanisms dictating the host cell viability gain importance in the context of viral infections. The premature apoptosis of infected cells could interrupt the pathogen replication cycle. On the other hand, cell death following the effective assembly of progeny particles may facilitate virus dissemination. Thus, various viruses can interfere with the apoptosis regulation network to their advantage. Research has shown that viral infections affect the intracellular amount of MCL-1 to modify the apoptotic potential of infected cells, fitting it to the “schedule” of the replication cycle. A growing body of evidence suggests that the virus-dependent deregulation of the MCL-1 level may contribute to several virus-driven diseases. In this work, we have described the role of MCL-1 in infections caused by various viruses. We have also presented a list of promising antiviral agents targeting the MCL-1 protein. The discussed results indicate targeted interventions addressing anti-apoptotic MCL1 as a new therapeutic strategy for cancers as well as other diseases. The investigation of the cellular and molecular mechanisms involved in viral infections engaging MCL1 may contribute to a better understanding of the regulation of cell death and survival balance.

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“…S63845 was also tested against KHSV [182]. As previously mentioned, this virus is associated with PEL, an aggressive B-cell cancer.…”

Section: Agent(s)mentioning

confidence: 99%