Expression, prognostic value and mechanism of SP100 family in pancreatic adenocarcinoma

Abstract

Background: Pancreatic adenocarcinoma (PAAD) is one of the most aggressive malignancies with a very poor prognosis. Exploring more therapeutic targets and prognostic biomarkers is of great significance to improve the prognosis of PAAD patients. Increasing evidence supports that the speckled protein (SP) 100 family is associated with human cancer and immune disorders. However, the function of the SP100 family members in PAAD is still unclear. Methods: R, Cytoscape, cBioPortal, and other software and online databases were used to comprehensively analyze the expression characteristics, prognostic value, and oncogenic mechanism of the SP100 family in PAAD. Results: The high expression of SP100 family members in PAAD was significantly correlated with poor clinicopathological features and poor prognosis of PAAD patients. Mechanistically, TP53 mutations were significantly associated with the expression levels of the SP100 family members, which were significantly coexpressed with M6A methylation regulators and were activated in multiple oncogenic pathways, including the EMT pathways. Moreover, we found that their expression levels were significantly correlated with the sensitivity of multiple traditional chemotherapeutic drugs. Conclusion: The SP100 family is closely related to the occurrence and development of PAAD and can be used as a new biomarker and therapeutic target for patients with PAAD.

SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway

“…Altered expression or mutations in these proteins can influence gene regulation and potentially contribute to tumor development (Seeler et al., 1998 ; Yordy et al., 2004 ). A previous study demonstrated a significant association between high SP family member expression in pancreatic adenocarcinoma (PAAD) and unfavorable clinicopathological characteristics as well as a poor prognosis for patients with PAAD (Duan et al., 2023 ). SP110 and SP140 showed high rates of nonsynonymous mutations in head and neck squamous cell carcinoma (Chang et al., 2020 ).…”

An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer

“…Gene families are established through a shared ancestral origin and demonstrate significant structural and functional resemblances, leading to the generation of related protein products [ 1 ]. Numerous gene families have been confirmed to be associated with the process of carcinogenesis [ 2 , 3 ]. The tripartite motif (TRIM) family has more than 80 members and is primarily distinguished by the interesting new gene (RING) domain, which serves as an E3-ubiquitin ligase [ 4 ].…”