Expression profiling of lncRNAs and mRNAs in placental site trophoblastic tumor (PSTT) by microarray

Gan, Jianfeng; Chen, Zhixian; Feng, Xuan; Wei, Zhi; Zhang, Sai; Du, Yan; Xu, Congjian; Zhao, Hongbo

doi:10.7150/ijms.65002

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…ADAMTS6 was significantly downregulated in placental site trophoblastic tumor (PSTT), a rare type of gestational trophoblastic neoplasms through interrogation of microarray data and confirmed by qRT-PCR analysis ( Gan et al, 2022 ). This finding was further validated via immunohistochemistry with diffuse ADAMTS6 positive staining in normal villi while reduced staining was apparent in PSTT cells ( Gan et al, 2022 ). Increased staining of ADAMTS6 is an indicator of poor prognosis in patients with esophageal squamous cell carcinoma ( Liu et al, 2018 ).…”

Section: Emerging Roles Of Adamts6 In Cancermentioning

confidence: 94%

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology

Mead

2022

Front. Mol. Biosci.

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ADAMTS family members control mammalian development and disease, primarily through their function as proteases, by regulation of extracellular matrix composition. Until recently, ADAMTS6 was known as one of the orphan proteinases of the nineteen-member family with a relatively unknown expression pattern and function. Emerging focus on this enzyme has started to uncover these unknowns and revealed a vast importance and requirement of ADAMTS6 in cardiovascular and musculoskeletal development. In addition, ADAMTS6 has been linked to numerous disease settings including several types of cancer. This review summarizes the necessity of ADAMTS6 during development, its role in disease and requirement for essential prospective studies to fully realize its biological implications and potential for therapeutic intervention.

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Section: Emerging Roles Of Adamts6 In Cancermentioning

confidence: 94%

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology

Mead

2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

show abstract

Expression profiling of lncRNAs and mRNAs in placental site trophoblastic tumor (PSTT) by microarray

Cited by 1 publication

References 43 publications

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology

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