Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Powell, Jason A.; Thomas, Daniel; Barry, Emma F.; Kok, Chung Hoow; McClure, Barbara J.; Tsykin, Anna; To, Luen Bik; Brown, Anna L.; Lewis, Ian D.; Herbert, Kirsten; Goodall, Gregory J.; Speed, Terence P.; Asou, Norio; Jacob, Bindya; Osato, Motomi; Haylock, David N.; Nilsson, Susan K.; D’Andrea, Richard J.; Lopez, Angel F.; Guthridge, Mark A.

doi:10.1182/blood-2009-02-204818

Cited by 49 publications

(56 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liersch et al performed three independent studies but only two were selected for inclusion. that OPN expression was inversely correlated with prognosis in AML patients (11,12,14). Whereas the majority of the publications had focused on solid tumors (18)(19)(20)(21), there have been recent studies on the role of OPN in hematological malignancies (10,12).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 20 studies were selected for detailed evaluation, 16 of which were excluded following full assessment (1 study was excluded due to a suspected population overlap and 15 studies lacked necessary data). Following careful evaluation based on the inclusion criteria, 4 eligible studies including a total of 492 patients were finally selected for the metaanalysis (11,12,14); the study performed by Liersch et al consisted of three independent researches. Two of the studies were performed in Germany (12), one in Chinese Taiwan (14) and one in Australia (11).…”

Section: Selection and Characteristics Of Studiesmentioning

confidence: 99%

“…Following careful evaluation based on the inclusion criteria, 4 eligible studies including a total of 492 patients were finally selected for the metaanalysis (11,12,14); the study performed by Liersch et al consisted of three independent researches. Two of the studies were performed in Germany (12), one in Chinese Taiwan (14) and one in Australia (11). The specimen size in each study varied from 52 to 261 patients and the median age of the patients ranged from 45 to 58 years.…”

Section: Selection and Characteristics Of Studiesmentioning

confidence: 99%

“…A number of studies recently demonstrated that overexpression of OPN is significantly associated with tumorigenesis and metastasis in several malignant tumors, such as breast, pulmonary, prostatic, thyroid, ovarian, bladder and gastrointestinal carcinomas (7)(8)(9). Furthermore, aberrant OPN expression has been correlated with poor prognosis of leukemia (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Chen

Ren

et al. 2017

mol clin onc

View full text Add to dashboard Cite

Abstract. Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random-effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum-based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43-2.35; P<0.001). Experimental findings indicate that OPN overexpression is associated with a poor prognosis in AML and may be of prognostic value for AML stage and metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Selection and Characteristics Of Studiesmentioning

confidence: 99%

Section: Selection and Characteristics Of Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Chen

Ren

et al. 2017

mol clin onc

View full text Add to dashboard Cite

show abstract

“…The data of Nameer Kirma showed the induction of cellular M-CSF and its receptor (c-fms) in cervical carcinomas and suggest that blocking CSF-1/c-fms might be a viable therapeutic strategy in the treatment of cervical cancer [12]. Moreover, intracellular M-CSF (including cytosol or nuclear M-CSF) was also identified pathologically in the cell lines of leukemia, breast cancer and Hepatocellular Carcinoma (HCC) [13][14][15]. Interestingly, nuclear M-CSF (nM-CSF) was found only in some tumor cells other than normal cells.…”

Section: Introductionmentioning

confidence: 99%

Nuclear M-CSF Accelerates DNA Replication and Cell Proliferation in HeLa Human Cervical Cancer Cells

Tu¹

2017

View full text Add to dashboard Cite

Macrophage colony-stimulating factor (M-CSF), also named colony-stimulating factor-1 (CSF-1), plays an important role in the process of proliferation and differentiation of the monocyte/macrophage lineage cells. Commonly, it is not easy to measure the expression of cellular M-CSF. However, recent studies have shown that M-CSF can be expressed at a high level in the cytoplasm and nuclei of some kinds of malignant tumors, which related to the poor prognosis. To explore the role and mechanism of nuclear M-CSF, in the present study we constructed the pCMV/nuc/M-CSF vector and transfected it into human HeLa nuclei. The results from our previous study indicated, M-CSF was stably expressed in HeLa nuclei, which were used as a model to determine the nuclear effects of M-CSF. There was a higher percentage of replicating nuclei in the transfected pCMV/nuc/M-CSF HeLa cells both in phase G1 and S. According to the data from the cell doubling time, antisense oligonucleotides and the experiments of the transplanted tumor in nude mice, nuclear M-CSF could promote the cell proliferation of HeLa cells both in vivo and in vitro. In conclusion, nuclear M-CSF could accelerate DNA replication and cell proliferation of cervical carcinoma.

show abstract

Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells

Yehudai‐Resheff

Attias‐Turgeman

Sabbah

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Hematopoietic progenitors, residing in the bone marrow (BM) niche, are supported by mesenchymal stromal cells (MSCs). Cytogenetic and molecular aberrations in these progenitors lead to acute myeloid leukemia (AML). The BM-MSC role in leukemogenesis is not fully elucidated. In the current study, an ex-vivo system of patient's own stroma (POS), best mimicking the in-vivo BM niche, has been developed aiming to unravel interactions and crosstalk between MSCs and AML cells.POS derived from AML patients at diagnosis (Dx), relapse (Rx) and remission (Rm) was compared to healthy donor MSCs in terms of their morphology, growth pattern, support of leukemia cell viability and cytokine profile. Compared to control MSCs, POS (Dx/Rx, Rm) demonstrated a reduced proliferation rate (35%), significantly slower expansion, enlarged cell area (3-4-fold) and provided preferential support to leukemic cells of the same individual. Cytokine profiling showed significantly higher secreted phosphoprotein-1 (SPP1) expression in Dx/Rx and Rm POS compared to healthy MSCs. Additionally, the angiopoietin-1 expression was elevated in Dx/Rx POS with a further increase in the AML cell presence. In conclusion, the fact that POS derived in active disease and remission exhibited similar morphological and functional characteristics, might imply the involvement of the BM niche in leukemogenesis.

show abstract

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Cited by 49 publications

References 48 publications

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Nuclear M-CSF Accelerates DNA Replication and Cell Proliferation in HeLa Human Cervical Cancer Cells

Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells

Contact Info

Product

Resources

About