Expression Profiles of Prostaglandin E<sub>2</sub> Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis

Xie, Li; Liu, Aiguo; Cui, Yonghua; Zhang, Yinping; Liao, Bo; Li, Ni-Ni; Wang, Xian-Song

doi:10.2500/ajra.2015.29.4205

Cited by 5 publications

(10 citation statements)

References 42 publications

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“…However, the expression was lowest in aspirin-sensitive patients [198,199]. Moreover, increased EP1 receptor expression was associated with the eosinophilic phenotype in patients with nasal polyps without aspirin intolerance [194]. In a recent study, exposure to cigarette smoking was related with diminished expression of EP2 and EP4 receptors in nasal polyps of patients with chronic rhinosinusitis, which might explain the severe inflammation caused by smoking [200].…”

Section: Nasal Polypsmentioning

confidence: 95%

“…Few studies have investigated PGs in nasal polyps, whereas comparatively more have assessed their roles in asthma or allergic rhinitis. However, the clinical relevance of PGs has been well demonstrated, even disregarding their association with aspirin sensitivity [194]. PGE 2 concentrations and COX-2 mRNA expression were lower in nasal polyp tissues than in nasal mucosas, either from healthy controls or from patients with chronic rhinosinusitis without nasal polyps.…”

Section: Nasal Polypsmentioning

confidence: 99%

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The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Lee

Kim

2020

IJMS

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Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD 2 , PGI 2 , PGE 2 , PGF 2 , and thromboxane B 2 . PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

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Section: Nasal Polypsmentioning

confidence: 95%

Section: Nasal Polypsmentioning

confidence: 99%

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Lee

Kim

2020

IJMS

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“…ECRSwNP and NECRSwNP represent two distinct endotypes of CRSwNP that exhibit different clinical and pathologic features [18][19][20][21]. For better management of ECRSwNP and NECRSwNP, there is a clear need to investigate the underlying different molecular mechanisms of these two endotypes.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis

Yao

Yang

et al. 2020

Bioscience Reports

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Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a heterogeneous disorder that can be classified into either eosinophilic or noneosinophilic endotypes. However, the immunological mechanisms of each remain unclear. The purpose of the present study was to compare and analyze inflammatory signatures of eosinophilic CRSwNP (ECRSwNP) and noneosinophilic CRSwNP (NECRSwNP). Cytokine antibody array was used to identify inflammatory mediators that were differentially expressed among ECRSwNP, NECRSwNP, and control groups. Then, bioinformatics approaches were conducted to explore biological functions and signaling pathways. In addition, pairwise correlation analyses were performed among differential levels of inflammatory mediators and tissue eosinophil infiltration. The results showed that nine mediators were significantly up-regulated in ECRSwNP, including eotaxin-2, eotaxin-3, CCL18, IL-4, IL-5, IL-10, IL-12p70, IL-13, and IL-15. Bioinformatics analysis indicated that these mediators were mainly enriched in leukocyte chemotaxis and proliferation, JAK-STAT cascade, asthma, and Th1 and Th2 cell differentiation. Furthermore, seven mediators were identified to be significantly up-regulated in NECRSwNP, including CCL20, resistin, transforming growth factor (TGF)-β2, triggering receptor expressed on myeloid cells 1 (TREM-1), CD14, glucocorticoid-induced tumor necrosis factor receptor related protein (GITR), and lipocalin-2. These mediators were closely associated with LPS responses, neutrophil chemotaxis and migration, and IL-17 signaling pathway. In addition, pairwise correlation analyses indicated that differential levels of inflammatory mediators in ECRSwNP and NECRSwNP were broadly correlated with each other and with tissue eosinophil infiltration. In conclusion, we found that ECRSwNP and NECRSwNP exhibited different patterns of inflammatory signatures. These findings may provide further insights into heterogeneity of CRSwNP.

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“…When comparing EP receptors in CRS subtypes, Xie et al 1 found enhanced EP1 receptor messenger RNA (mRNA) and protein expression in eosinophilic CRS with nasal polyps (CRSwNP). However, EP4 mRNA levels were higher than EP1, EP2, and EP3 levels in controls; in CRS without nasal polyps (CRSsNP); and in noneosinophilic CRSwNP.…”

Section: T His Issue Of American Journal Of Rhinology Andmentioning

confidence: 99%

“…However, EP4 mRNA levels were higher than EP1, EP2, and EP3 levels in controls; in CRS without nasal polyps (CRSsNP); and in noneosinophilic CRSwNP. 1 Nasal tissue eosinophilia is a hallmark of CRSwNP, especially in patients from Western countries. Results of studies have shown an association between tissue eosinophilia and polyp recurrence.…”

Section: T His Issue Of American Journal Of Rhinology Andmentioning

confidence: 99%

Editorial: Inflammatory and Allergic Diseases of the Upper Airways

Mahdavinia¹

2015

Am J Rhinol�Allergy

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Editorial: Inflammatory and allergic diseases of the upper airways T his issue of American Journal of Rhinology and Allergy (AJRA) covers a diverse selection of articles on basic and clinical aspects of inflammatory diseases of the upper airways. One such disease, chronic rhinosinusitis (CRS), significantly lowers quality of life. Despite recent progress, however, CRS remains poorly understood. A few of the articles in this AJRA issue focus on the pathophysiology of CRS.The literature indicates a role for prostaglandin-E2 and E-prostanoid (EP) receptors in CRS. When comparing EP receptors in CRS subtypes, Xie et al. 1 found enhanced EP1 receptor messenger RNA (mRNA) and protein expression in eosinophilic CRS with nasal polyps (CRSwNP). However, EP4 mRNA levels were higher than EP1, EP2, and EP3 levels in controls; in CRS without nasal polyps (CRSsNP); and in noneosinophilic CRSwNP. 1 Nasal tissue eosinophilia is a hallmark of CRSwNP, especially in patients from Western countries. Results of studies have shown an association between tissue eosinophilia and polyp recurrence. In their retrospective analysis from China of 387 patients with CRSwNP, Lou et al. 2 found a significant correlation between tissue eosinophilia and polyp recurrence. They showed that tissue eosinophils Ͼ27% of total cells or a tissue eosinophil absolute count of Ն55 eosinophils per high power field is a reliable prognostic indicator for nasal polyp recurrence within 2 years after surgery. 2 CRS has been linked to imbalances in the production of eicosanoids (arachidonic acid metabolites), which results from phospholipid hydrolysis by phospholipase A2 (PLA2). Mruwat et al. 3 investigated the expression of PLA2s and multiple cytokines in super-antigen Staphylococcus aureus enterotoxin stimulated human nasal polyps from patients with CRSwNP. Stimulation of nasal polyp cells by S. aureus enterotoxin induced cytokine secretion and enhanced expression of several secretory PLA2 and calciumindependent PLA2, while suppressing cytoplasmic PLA2 expression. This supports a role for secretory PLA2s in the pathophysiology of CRS. 3 Wang et al. 4 evaluated the ethmoid bone tissue samples from a group of patients with CRS by histologic examination and quantitative real-time reverse transcription polymerase chain reaction and showed an increased infiltration of eosinophils in the periosteum, along with neo-osteogenesis in CRS. The investigators found increased expression of TGF-␤1, TGF-␤ receptor I, and p-Smad3 in patients with CRSwNP compared with CRSsNP at the mRNA and protein levels. The investigators concluded that these findings were indicative of a potential role for eosinophils in the bone remodeling process in CRSwNP. 4 Oral steroids are used routinely in the management of CRS. However, providers should be aware of potential adverse effects and complications with these medications. In this issue of AJRA, Poetker 5 comprehensively reviews existing data on the risks of oral steroids and discusses the use of oral steroids in CRS.With the recent emergence o...

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Expression Profiles of Prostaglandin E₂ Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis

Cited by 5 publications

References 42 publications

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis

Editorial: Inflammatory and Allergic Diseases of the Upper Airways

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Expression Profiles of Prostaglandin E2 Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis

Cited by 5 publications

References 42 publications

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis

Editorial: Inflammatory and Allergic Diseases of the Upper Airways

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Expression Profiles of Prostaglandin E₂ Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis