Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction

He, Guangbin; Li, Jie; Nie, Zhiqiang; Sun, Shuo; Feng, Yingqing; Huang, Yu-Qing

doi:10.1155/2022/3458227

Cited by 2 publications

(1 citation statement)

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“…Previous studies have shown that polymorphisms in miR‐146a (Xiong et al., 2014), miR‐149 (Ding et al., 2013), miR‐196a2 (Zhi et al., 2012; Zhou et al., 2010), miR‐499 (Liu et al., 2014; Zhi et al., 2012), and miR‐423 (He et al., 2022) are involved in the progression of CVDs including ischemic stroke, CAD, and MI (Chen et al., 2014). The rs2910164 in miRNA‐146a was found to be linked with the risk of an acute coronary syndrome (ACS) and CAD (Huang et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

The miRNA variants MIR196A2 (rs11614913) and MIR423 (rs6505162) contribute to an increase in the risk of myocardial infarction

Uzair,

Haq,

Ali

et al. 2023

Molec Gen & Gen Med

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IntroductionMicroRNAs (miRNAs) are small, single‐stranded RNA molecules that negatively regulate gene expression and play a key role in the pathogenesis of human diseases. Recent studies have suggested that miRNAs contribute to cardiovascular diseases (CVDs). However, the association between single‐nucleotide polymorphisms (SNPs) in miRNAs and myocardial infarction (MI) remains in infancy.AimThe current study was designed to find out the association of SNPs in MIR196A2 and MIR423 (rs11614913 and rs6505162, respectively).MethodsUsing Tetra‐Primer Amplification Refractory Mutation System‐Polymerase Chain Reaction (T‐ARMS PCR) in 400 cases (MI patients) and 336 healthy controls. Using different inheritance models (co‐dominant, homozygous dominant, homozygous recessive, and additive models), the association of these SNPs was genotyped with MI risk.ResultsFor variant rs11614913, significant distribution of the genotypes among the cases and controls was determined by co‐dominant [χ2 = 29.19, 2; p value < 0.0001], dominant (C/C vs. C/T + T/T) [OR = 0.45 (0.34 to 0.61); p < 0.0001], recessive (T/T vs. C/T + C/C) [OR = 1.009 (0.63 to 1.63); p‐value p value > 0.999], and additive models [OR = 0.65 (0.52 to 0.80); p value = 0.0001]. Similarly, a significant association of rs6505162 was determined by co‐dominant [χ2 = 24.29, 2; p value < 0.0001], dominant (C/C vs. A/C+ A/A) [OR = 0.44 (0.32 to 0.61); p value < 0.0001], recessive (A/A vs. A/C + C/C) [OR = 1.29 (0.85 to 1.98); p value = 0.28], and additive models [OR = 0.65 (0.52 to 0.81); p value = 0.0001].ConclusionTherefore, the current study showed that both variants rs11614913 and rs6505162 are significantly associated with MI in the Pakistani population.

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