Expression profile of the small heat-shock protein alpha-B-crystallin in operated-on non-small-cell lung cancer patients: clinical implication☆☆☆

Cherneva, Radostina; Petrov, Danail; Georgiev, Ognian; Slavova, Yanina; Toncheva, Draga; Stamenova, Maria; Trifonova, N.

doi:10.1016/j.ejcts.2009.06.038

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…Overexpression of αB-crystallin has been detected in a number of types of human cancer, including hepatocellular carcinoma, glioma, lung, gastric and breast cancer. The expression in cancer has been found to be correlated with lymph node metastasis, low rates of survival and poor prognosis of patients, and αB-crystallin was even considered a novel oncoprotein in basal-like breast carcinoma (11)(12)(13)(14)(15). In the current study of OVC and OSCC, we also found the overexpression of αB-crystallin.…”

Section: Discussionsupporting

confidence: 62%

“…By binding non-naive, non-host proteins or specific apoptosisrelated proteins during cellular stress, αB-crystallin protects cells from thermal shock, osmotic shock, oxidative insults, ischemia or exposure to heavy metals, and sustains cell homeostasis (9,10). αB-crystallin may play a significant role in cancer, as its overexpression has been reported in renal, hepatocellular and gastric carcinoma, glioma, and lung and breast cancers (11)(12)(13)(14). In cancer, αB-crystallin has demonstrated anti-apoptotic properties and is even considered to be a potential oncoprotein in a number of types of human cancer (15).…”

Section: Introductionmentioning

confidence: 99%

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Expression of αB-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma

et al. 2011

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Abstract. αB-crystallin, a member of the small heat shock protein family, acts as a molecular chaperone. αB-crystallin has been found to be overexpressed in a number of cancer tissues, including head and neck cancers. Overexpression of αB-crystallin in cancer tissue may be related to its anti-apoptotic properties; however, its mechanism of action remains unclear. The aim of this study was to investigate the antiapoptotic role of αB-crystallin in oral verrucous carcinoma (OVC). Since oral squamous cell carcinoma (OSCC) is the most common tumor of the oral cavity, we selected OSCC as a control group. Immunohistochemical staining was used to evaluate the expression levels. The results showed that the expression of αB-crystallin was detected in OVC, OSCC and normal oral mucosa (NM). The expression in OVC was higher compared to that of NM, but lower compared to OSCC, indicating that OVC was less aggressive than OSCC with respect to malignancy potential. Furthermore, we found that in OVC, the increased expression of αB-crystallin coincided with the decreased expression of activated caspase-3. The results indicated that αB-crystallin may play an antiapoptotic role via inhibition of the activation of caspase-3 in OVC.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Expression of αB-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma

et al. 2011

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“…Similarly, high levels of HspB5 are associated with low survival rate in hepatocellular carcinoma (Huang et al 2013 ;Tang et al 2009 ), ovarian carcinoma (Volkmann et al 2013 ), clear cell renal cell carcinoma (Ho et al 2013 ) and head and neck squamous cell carcinoma (van de Schootbrugge et al 2013 ). In non-small-cell lung cancer only the nuclear and not the cytoplasmic localized HspB5 correlated with poor survival (Cherneva et al 2010 ).…”

Section: Hspb5 Expression In Cancersmentioning

confidence: 98%

Role of Small Heat Shock Protein HspB5 in Cancer

Boelens¹

2015

Heat Shock Proteins

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HspB5, also called αB-crystallin, is a ubiquitous small heat shock protein (sHSP) that is strongly induced by a variety of stresses, but that also functions constitutively in multiple cell types. Extensive research has demonstrated that HspB5 acts as an ATP-independent molecular chaperone by binding unfolding proteins and protecting cells from damage due to irreversible protein aggregation. As a result of its importance in protein homeostasis HspB5 is of signifi cant interest to many areas of cell biology, including the development of cancer. However, the molecular understanding of HspB5's role in cancer is only beginning to emerge. In this chapter an overview is given of data that provide insight into the oncogenic role of HspB5 in human cancer.

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“…The cytoplasmic expression of αB-crystallin in the tumours is related to the local invasion, while nuclear expression is more commonly detected in advanced stages, and αB-crystallin is determined as biomarker of aggressive tumour biology. They conclude that αB-crystallin plays an essential role in NSCLCs biology and its nuclear staining is an independent factor of poor survival [ 12 ].…”

mentioning

confidence: 99%

“…Cherneva et al [ 12 ] investigate the expression profile of αB-crystallin in non-small cell lung cancers (NSCLCs). In their study, cytoplasmic and nuclear expression is detected.…”

mentioning

confidence: 99%

Evaluation of the Expression of the Low Weight Heat Shock Protein αB-crystallin in Pulmonary Neuroendocrine Tumours

Marinova¹,

Slavova²,

Trifonova³

et al. 2013

Proceeding BAS

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αB-crystallin is a major heat-inducible small heat shock protein, which is supposed to be implicated in tumour cell proliferation, differentiation, invasion, metastasis and apoptosis. Still the expression pattern of the phosphorylated on serin 59 form of αB-crystallin in lung cancer is not yet investigated.The aim of the present work is to study this pattern in different histological subtypes of pulmonary neuroendocrine tumours (pNETs).Surgically resected specimens from 143 patients with pNETs were studied. The histological subtype, pathological Tumour-Node-Metastasis stage and the immunohistochemical expression of phosphorylated αB-crystallin were evaluated.We demonstrated that the nucleus was the major localization site of the protein although there were some rare cases showing also diffuse cytoplasmic expression. High grade pNETs (small cell lung carcinoma and large cell neuroendocrine carcinoma) showed nuclear expression in all cases but most frequently it was in less than 50% of the tumour cells; cytoplasmic expression was shown in single cases. Just the opposite was observed in low and intermediate grade pNETs (typical carcinoids and atypical carcinoids) -nuclear expression was not seen in all of the cases, but when it was present it was in almost all tumour cells; the cases expressing phosphorylated αB-crystallin also in the cytoplasm were mainly typical carcinoids. We demonstrated that cytoplasmic 281 expression was associated with earlier stage and absence of metastases, which may determine it as a potential marker for a favourable prognosis in patients.We conclude that phosphorylated αB-crystallin probably plays a major role in pNETs biology, it may be associated with tumour grade, it may have a prognostic value, and it may be used as future target for therapy.Key words: heat shock proteins, αB-crystallin, pulmonary neuroendocrine tumours 1. Introduction. The lung cancer clinical course is determined by its histological and biological features [ 1 ]. The prognosis in lung cancer patients is associated with certain clinicopathological features as histological type, tumour size and invasion of adjacent structures (T-status), lymph node metastases (N-status) and pTNM (pathological Tumour-Node-Metastasis) stage [ 2, 3 ]. These features are not always sufficient for complete and objective assessment of lung tumours, which requires in-depth studies of immunohistochemical and genetic indicators that could serve as better markers for determining the biological behaviour of these tumours [ 4 ].Adenocarcinoma and squamous cell carcinoma are the most common lung tumours (85% of all lung cancers) and thus they are the most actively studied group. A more special and rare group are the pulmonary neuroendocrine tumours (pNETs) comprising very different tumours regarding biological behaviour and prognosis -typical carcinoids (TCs), atypical carcinoids (AtCs), small cell lung carcinomas (SCLCs) and large-cell neuroendocrine carcinomas (LCNECs) Various factors (such as hyperthermia, hypoxia, heavy metals, ethan...

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Expression profile of the small heat-shock protein alpha-B-crystallin in operated-on non-small-cell lung cancer patients: clinical implication☆☆☆

Cited by 13 publications

References 22 publications

Expression of αB-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma

Expression of αB-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma

Role of Small Heat Shock Protein HspB5 in Cancer

Evaluation of the Expression of the Low Weight Heat Shock Protein αB-crystallin in Pulmonary Neuroendocrine Tumours

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