Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected pre-neoplastic and neoplastic human gastric epithelium

Subramani, Durai B.; Venkataraman, Jayanthi; Devaraj, Niranjali; Reis, Celso A.; Devaraj, Halagowder

doi:10.1186/1476-4598-5-10

Cited by 84 publications

(42 citation statements)

References 35 publications

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“…25, 26 We analyzed the expression of KLF4 and MUC2 in human gastric cancer samples and found a negative correlation between KLF4 and MUC2 levels in signet ring cell carcinoma and mucinous adenocarcinoma. Signet ring cell carcinoma is a special subtype of mucinous adenocarcinoma, which denotes a very poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

KLF4 deletion alters gastric cell lineage and induces MUC2 expression

Chen

Lin

et al. 2016

Cell Death Dis

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Gastric cancer is one of the most common types of cancer in the world, particularly in underdeveloped countries. The mechanism of gastric cancer is less understood compared with other types of gastrointestinal (GI) cancers. Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor and is a potential tumor suppressor in GI cancers. In this study, we have generated two mouse models, Rosa-Cre;Klf4fl/fl and Lgr5-Cre;Klf4fl/fl. KLF4 was deleted by Rosa-Cre in the gastric epithelia cells or by Lgr5-Cre in the antral stem cells in the adult mice. KLF4 deletion resulted in increased proliferating cells and decreased pit mucous cells. Surprisingly, the intestinal goblet cell marker, MUC2, which is not expressed in normal gastric tissues, was strongly induced at the base of the KLF4-deleted antral glands. To understand the clinical relevance of these findings, we analyzed the expression of KLF4 and MUC2 in human gastric cancer. In a subset of human gastric cancer, the expression of KLF4 is negatively associated with MUC2 expression. In conclusion, KLF4 is essential for normal homeostasis of antral stem cells; loss of KLF4 and expression of MUC2 could be important markers for gastric cancer diagnosis.

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Section: Discussionmentioning

confidence: 99%

KLF4 deletion alters gastric cell lineage and induces MUC2 expression

Chen

Lin

et al. 2016

Cell Death Dis

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“…MUC5AC has also been shown to be involved in neoplastic progression. For instance, while it is expressed by the normal gastric mucosa, its expression (together with that of MUC1 and MUC6) is lost in type I intestinal metaplasia, a pre-malignant lesion that precedes gastric adenocarcinoma [23]. Like other polymeric mucins present in the airway secretions, the protein backbone of MUC5AC possesses a large number of disulfide bridges and adopts a random coil conformation in solution.…”

Section: The Muc Family Of Mucins - Structural and Functionally Divermentioning

confidence: 99%

Role of mucins in the skin during benign and malignant conditions

Chakraborty¹,

Bonthu²,

Swanson³

et al. 2011

Cancer Letters

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Skin related diseases comprise a major health challenge to the practicing physician, and constitute a significant psychological, social and financial burden to the society. Further, skin cancer, especially non-melanoma skin cancer is currently the leading type of malignancy in the Western world. Given the huge burden of skin diseases, there is growing emphasis on understanding their pathophysiology, and towards their early detection. Mucins are high molecular weight O- and N-linked glycoproteins that have emerged in recent years as important molecules in maintaining health and in promoting or protecting against inflammation and cancer. They have also begun to emerge as highly specific diagnostic and prognostic markers and novel therapeutic targets in several malignant disorders. However, their role in cutaneous pathologies has remained largely obscured. The present review provides the expression patterns and proposed role of mucins in the healthy skin and various benign and malignant skin diseases. The review has immense clinical significance as the availability of highly specific reagents including monoclonal antibodies against mucins makes them extremely attractive targets for specific diagnosis and/or immunotherapy of benign and malignant cutaneous diseases.

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“…Mucins are high molecular weight glycoproteins that are synthesized by secretory epithelial cells as membrane or secreted proteins and are the major component of the mucous layer that protects the gut epithelium from chemical and mechanical aggressions (Babu, Jayanthi, Devaraj, Reis, & Devaraj, 2006;Balan, 2011). Mucus (mucin) plays a vital role in GIT surface integrity, and failure of mucin secretion and/or mucin expression may lead to numerous pathologies such as inflammatory intestinal diseases and cancer (Moughan, Rutherfurd, & Balan, 2013).…”

Section: Effect Of Ig On Gut Mucinmentioning

confidence: 99%

“…Mucin-producing goblet cells along with antimicrobial peptides, luminal Ig, lysozymes and resident microbiota together contribute to innate immunity and provide the front line of defence against microbial pathogens (Balan, 2011). Since mucins play an important role in defending the underlying epithelial lining, any quantitative modification in mucin secretion may alter this defensive barrier and thus have significant physiological implications (Babu et al, 2006). It is well known that GIT diseases and stress modify the mucus layer both quantitatively and qualitatively.…”

Section: Effect Of Ig On Gut Mucinmentioning

confidence: 99%

Impact of oral immunoglobulins on animal health—A review

Balan

Sik‐Han

Moughan

2019

Animal Science Journal

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Immunoglobulin (Ig) is the one of the main anti‐infective components of blood, colostrum and breast milk. It is the unique glycoprotein that defends the body from harmful bacteria, viruses and other environmental pathogens by either binding to them or by forming an encapsulating barrier. The expansion of antimicrobial and immunomodulatory products from natural sources for dietary supplementation in both animals and humans is an ever growing and thriving area of research. Purified Ig from sheep serum (ovine serum Ig) is one such candidate product. Recent work has shown the various biological effects of oral Ig in different animal models including its effect on growth, immunity, intestinal growth and gut barrier function. The objective of this paper is to review the results of recent studies demonstrating the effects of oral Ig in both pathogenic and non‐pathogenic animal models and to suggest a possible mechanism of its action. Overall, purified oral Ig improves growth of healthy (and challenged) rats and defends against enteric infection by immunomodulation, mucin protein and/or modification of commensal microbial composition. The findings contribute to knowledge of how orally administered ovine Ig can influence and enhance key indicators of gut function and overall growth performance in an animal model.

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Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected pre-neoplastic and neoplastic human gastric epithelium

Cited by 84 publications

References 35 publications

KLF4 deletion alters gastric cell lineage and induces MUC2 expression

KLF4 deletion alters gastric cell lineage and induces MUC2 expression

Role of mucins in the skin during benign and malignant conditions

Impact of oral immunoglobulins on animal health—A review

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