Expression profile of microRNAs in rat hippocampus following lithium–pilocarpine-induced status epilepticus

Hu, Keqi; Zhang, Chen; Long, Lili; Long, Xiaoyan; Feng, Li; Li, Yi; Xiao, Bo

doi:10.1016/j.neulet.2010.11.040

Cited by 102 publications

(105 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MiR-132 has been shown to be enriched in the mammalian brain, it also has been found to be highly conserved and enriched in neurons (Remenyi et al, 2010;Vo et al, 2005). Our results revealed prominent upregulation of miR-132 in hippocampal neuronal culture model of epilepsy, in association with this result, SE in vivo led to the rise in miR-132 level (Hu et al, 2011;Jimenez-Mateos et al, 2011;Risbud and Porter, 2013), the increased expression of miR-132 was also observed in human temporal lobe epilepsy (Peng et al, 2013). Upregulation of miR-132 in these studies may provide a meaningful line with regard to the role of this miR in the epileptogenic process.…”

Section: Discussionsupporting

confidence: 73%

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

et al. 2015

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 73%

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

et al. 2015

View full text Add to dashboard Cite

“…Human temporal lobe epilepsy and experimentally induced epilepsy result in changes of the level of specific miRNAs in brain tissue in a region-and even neural compartment-dependent manner [78][79][80][81]. If one considers different induction protocols, experimental designs and animal species used, then a core set of four epilepsyrelated miRNAs has emerged (miR-132, miR-134, miR-124, miR-34a) [82][83][84][85]. Pilocarpine-induced epilepsy results in increase of hippocampal pri-miR-132 [60] and miR-132 level [60,85].…”

Section: (C) Mirnas In Epilepsymentioning

confidence: 99%

“…If one considers different induction protocols, experimental designs and animal species used, then a core set of four epilepsyrelated miRNAs has emerged (miR-132, miR-134, miR-124, miR-34a) [82][83][84][85]. Pilocarpine-induced epilepsy results in increase of hippocampal pri-miR-132 [60] and miR-132 level [60,85]. miR-132 is also upregulated in kainic-acid-induced epilepsy (via injections into amygdala) only if the destructive stimulus is applied, but not if the animals are preconditioned to the seizures [81].…”

Section: (C) Mirnas In Epilepsymentioning

confidence: 99%

MicroRNAs and synaptic plasticity—a mutual relationship

Aksoy‐Aksel

Zampa

Schratt

2014

Phil. Trans. R. Soc. B

105

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are rapidly emerging as central regulators of gene expression in the postnatal mammalian brain. Initial studies mostly focused on the function of specific miRNAs during the development of neuronal connectivity in culture, using classical gain-and loss-of-function approaches. More recently, first examples have documented important roles of miRNAs in plastic processes in intact neural circuits in the rodent brain related to higher cognitive abilities and neuropsychiatric disease. At the same time, evidence is accumulating that miRNA function itself is subjected to sophisticated control mechanisms engaged by the activity of neural circuits. In this review, we attempt to pay tribute to this mutual relationship between miRNAs and synaptic plasticity. In particular, in the first part, we summarize how neuronal activity influences each step in the lifetime of miRNAs, including the regulation of transcription, maturation, gene regulatory function and turnover in mammals. In the second part, we discuss recent examples of miRNA function in synaptic plasticity in rodent models and their implications for higher cognitive function and neurological disorders, with a special emphasis on epilepsy as a disorder of abnormal nerve cell activity.

show abstract

“…Recently, the ability of status epilepticus to alter the microRNA expression profile in the selectively vulnerable hippocampal CA3 was evaluated by means of microRNA array analysis, an unbiased, epigenome-wide approach to detect alterations in microRNA expression (Jimenez-Mateos et al, 2011;Hu et al, 2011;Song et al, 2011). In Table 1, we summarize alterations in microRNA expression associated with status epilepticus from three independent studies.…”

Section: The Role Of Micrornas In Epilepsymentioning

confidence: 99%

“…In contrast, the three studies showed no consensus (or overlap) in downregulated microRNAs (Table 1, Lower panel). GO analysis classified upregulated microRNAs as components of ERK-MAPK signaling, TGF-b signaling, and/or tight junctions (Hu et al, 2011). A subset of the downregulated microRNAs are implicated in synaptic plasticity, and T-cell receptor signaling.…”

Section: The Role Of Micrornas In Epilepsymentioning

confidence: 99%

Epigenetic Mechanisms in Stroke and Epilepsy

Hwang

Aromolaran

Zukin

2012

Neuropsychopharmacol

View full text Add to dashboard Cite

Epigenetic remodeling and modifications of chromatin structure by DNA methylation and histone modifications represent central mechanisms for the regulation of neuronal gene expression during brain development, higher-order processing, and memory formation. Emerging evidence implicates epigenetic modifications not only in normal brain function, but also in neuropsychiatric disorders. This review focuses on recent findings that disruption of chromatin modifications have a major role in the neurodegeneration associated with ischemic stroke and epilepsy. Although these disorders differ in their underlying causes and pathophysiology, they share a common feature, in that each disorder activates the gene silencing transcription factor REST (repressor element 1 silencing transcription factor), which orchestrates epigenetic remodeling of a subset of 'transcriptionally responsive targets' implicated in neuronal death. Although ischemic insults activate REST in selectively vulnerable neurons in the hippocampal CA1, seizures activate REST in CA3 neurons destined to die. Profiling the array of genes that are epigenetically dysregulated in response to neuronal insults is likely to advance our understanding of the mechanisms underlying the pathophysiology of these disorders and may lead to the identification of novel therapeutic strategies for the amelioration of these serious human conditions.

show abstract

Expression profile of microRNAs in rat hippocampus following lithium–pilocarpine-induced status epilepticus

Cited by 102 publications

References 13 publications

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons

MicroRNAs and synaptic plasticity—a mutual relationship

Epigenetic Mechanisms in Stroke and Epilepsy

Contact Info

Product

Resources

About