Expression profile of long non-coding RNAs in rat models of OSA-induced cardiovascular disease: new insight into pathogenesis

Chen, Qingshi; Lin, Guang-Tan; Huang, Jiefeng; Chen, Gongping; Huang, Xiaoyun

doi:10.1007/s11325-018-1753-0

Cited by 22 publications

(17 citation statements)

References 26 publications

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“…Also, the expression profiles of lncRNAs are affected by various factors, including hypoxia, 34‐36 energy stress 37‐39 and particulate matter 40,41 . Moreover, the impact of CIH on the expression profiles of lncRNAs and mRNAs in the heart samples of rat model has been examined previously 42 . A total of 289 dysregulated lncRNAs were identified following 8 weeks of CIH, with a majority of novel lncRNAs, whose functions have not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…40,41 Moreover, the impact of CIH on the expression profiles of lncRNAs and mRNAs in the heart samples of rat model has been examined previously. 42 A total of 289 dysregulated lncRNAs were identified following 8 weeks of CIH, with a majority of novel lncRNAs, whose functions have not yet been elucidated. Herein, we showed that the expression of multiple lncRNAs was altered drastically after exposure to CIH for 8 weeks, whereas in the MI mice, 1482 lncRNAs were altered following CIH treatment (1235 increased and 247 decreased).…”

Section: Discussionmentioning

confidence: 99%

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Impact of chronic intermittent hypoxia on the long non‐coding RNA and mRNA expression profiles in myocardial infarction

et al. 2020

J Cellular Molecular Medi

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of chronic intermittent hypoxia on the long non‐coding RNA and mRNA expression profiles in myocardial infarction

et al. 2020

J Cellular Molecular Medi

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“…Although genomics or proteomics results about CIH or OSA differ from ours, there are several common proteins, pathways, and functional proteins. Analysis of long noncoding RNA expression in the rat model of CIH showed that cytokine-cytokine receptor interactions were enriched in downregulated transcripts [11]. According to Jurado-Gamez, Bernabe et al [10] and Li et al [42], a serum proteomic study showed that APOA4 expression…”

Section: Plos Onementioning

confidence: 99%

“…There have been several recent proteomics [7][8][9][10] and genomics [11][12][13][14][15] studies aimed at elucidating the pathophysiology of OSA. Isobaric tags for relative and absolute quantitation (iTRAQ) have been widely employed in quantitative proteomics, and many recent studies have focused on OSA [10] and CIH.…”

Section: Introductionmentioning

confidence: 99%

Novel proteins associated with chronic intermittent hypoxia and obstructive sleep apnea: From rat model to clinical evidence

Tang

Yang

et al. 2021

PLoS ONE

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Objective To screen for obstructive sleep apnea (OSA) biomarkers, isobaric tags for relative and absolute quantitation (iTRAQ)-labeled quantitative proteomics assay was used to identify differentially expressed proteins (DEPs) during chronic intermittent hypoxia (CIH). Method The iTRAQ technique was applied to compare DEPs in the serum of a CIH rat model and control group. Biological analysis of DEPs was performed using Gene Ontology and Kyoto Encyclopedia to explore related biological functions and signaling pathways. Enzyme-linked immunosorbent assay (ELISA) was performed to validate their expression in sera from patients with OSA and CIH rats. Results Twenty-three DEPs (fold change ≥1.2 or ≤0.833, p<0.05) were identified, and two DEPs (unique peptides>3 and higher coverage) were further verified by ELISA in the CIH rat model and OSA subject: apolipoprotein A-IV (APOA4, p<0.05) and Tubulin alpha-1A chain (TUBA1A, p<0.05). Both groups showed significant differences in the expression levels of DEPs between the CIH and control groups and the severe OSA and non-OSA groups. APOA4 was found to be upregulated and TUBA1A downregulated in both the sera from OSA patients and CIH rats, on comparing proteomics results with clinical results. There were two pathways that involved three DEPs, the mitogen-activated protein kinase (MAPK) signaling pathway (p<0.05) and cytokine-cytokine receptor interaction (p<0.05). Conclusion APOA4 and TUBA1A may be potential novel biomarkers for CIH and OSA, and may play an important role in the development of OSA complications.

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“…A small-scale microarray study on the heart samples of rats exposed to eight weeks of CIH first identified 289 differentially expressed lncRNAs, among which three up-regulated lncRNAs (XR_596701, XR_344474, and ENSRNOT00000065561) and three down-regulated lncRNAs (XR_600374, XR_590196, and XR_597099) were verified by quantitative reverse-transcription polymerase chain reaction. This provides new insight into the potential role of lncRNAs in the pathogenesis of OSA-induced cardiovascular disease [75] (Table 2).…”

Section: Non-coding Rnasmentioning

confidence: 99%

Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep Apnea

Chen

Hsu

Hsiao

2019

IJMS

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Epigenetics is defined as the heritable phenotypic changes which do not involve alterations in the DNA sequence, including histone modifications, non-coding RNAs, and DNA methylation. Recently, much attention has been paid to the role of hypoxia-mediated epigenetic regulation in cancer, pulmonary hypertension, adaptation to high altitude, and cardiorenal disease. In contrast to sustained hypoxia, chronic intermittent hypoxia with re-oxygenation (IHR) plays a major role in the pathogenesis of various adverse consequences of obstructive sleep apnea (OSA), resembling ischemia re-perfusion injury. Nevertheless, the role of epigenetics in the pathogenesis of OSA is currently underexplored. This review proposes that epigenetic processes are involved in the development of various adverse consequences of OSA by influencing adaptive potential and phenotypic variability under conditions of chronic IHR. Improved understanding of the interaction between genetic and environmental factors through epigenetic regulations holds great value to give deeper insight into the mechanisms underlying IHR-related low-grade inflammation, oxidative stress, and sympathetic hyperactivity, and clarify their implications for biomedical research.

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Expression profile of long non-coding RNAs in rat models of OSA-induced cardiovascular disease: new insight into pathogenesis

Cited by 22 publications

References 26 publications

Impact of chronic intermittent hypoxia on the long non‐coding RNA and mRNA expression profiles in myocardial infarction

Impact of chronic intermittent hypoxia on the long non‐coding RNA and mRNA expression profiles in myocardial infarction

Novel proteins associated with chronic intermittent hypoxia and obstructive sleep apnea: From rat model to clinical evidence

Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep Apnea

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