Expression profile of KIR3DS1/KIR3DL1 receptors in association with immunological responses in TB, HIV and HIV/TB infected patients

Shaukat, Sobia Naz; Nasir, Faizan; Raza, Afsheen; Khanani, Rafiq; Uddin, Shahab; Kazmi, Shahana Urooj

doi:10.1016/j.micpath.2023.106145

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…These results are similar to those in other African populations [ 106 , 107 , 108 ]. KIR3DS1 / KIR3DL1 receptors are highly relevant in Africa due to their association with diseases such as tuberculosis and HIV infection [ 109 ].…”

Section: Hla/kir Interaction and Association With Diseasementioning

confidence: 99%

Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations

Santiago-Lamelas,

Castro-Santos,

Carracedo

et al. 2024

Biomedicines

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Human leukocyte antigen (HLA) molecules and their relationships with natural killer (NK) cells, specifically through their interaction with killer-cell immunoglobulin-like receptors (KIRs), exhibit robust associations with the outcomes of diverse diseases. Moreover, genetic variations in HLA and KIR immune system genes offer limitless depths of complexity. In recent years, a surge of high-powered genome-wide association studies (GWASs) utilizing single nucleotide polymorphism (SNP) arrays has occurred, significantly advancing our understanding of disease pathogenesis. Additionally, advances in HLA reference panels have enabled higher resolution and more reliable imputation, allowing for finer-grained evaluation of the association between sequence variations and disease risk. However, it is essential to note that the majority of these GWASs have focused primarily on populations of Caucasian and Asian origins, neglecting underrepresented populations in Latin America and Africa. This omission not only leads to disparities in health care access but also restricts our knowledge of novel genetic variants involved in disease pathogenesis within these overlooked populations. Since the KIR and HLA haplotypes prevalent in each population are clearly modelled by the specific environment, the aim of this review is to encourage studies investigating HLA/KIR involvement in infection and autoimmune diseases, reproduction, and transplantation in underrepresented populations.

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Section: Hla/kir Interaction and Association With Diseasementioning

confidence: 99%

Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations

Santiago-Lamelas,

Castro-Santos,

Carracedo

et al. 2024

Biomedicines

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Network biology and bioinformatics-based framework to identify the impacts of SARS-CoV-2 infections on lung cancer and tuberculosis

Waaje,

Sarkar,

Islam

2024

Preprint

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The severe acute respiratory syndrome coronavirus 2 (SARSCoV 2) is a coronavirus variation responsible for COVID19, the respiratory disease that triggered the COVID19 pandemic. The primary aim of our study is to elucidate the complex network of interactions between SARS CoV 2, tuberculosis, and lung cancer employing a bioinformatics and network biology approach. Lung cancer is the leading cause of significant illness and death connected to cancer worldwide. Tuberculosis (TB) is a prevalent medical condition induced by the Mycobacterium bacteria. It mostly affects the lungs but may also have an influence on other areas of the body. Coronavirus disease (COVID19) causes a risk of respiratory complications between lung cancer and tuberculosis. SARSCoV 2 impacts the lower respiratory system and causes severe pneumonia, which can significantly increase the mortality risk in individuals with lung cancer. We conducted transcriptome analysis to determine molecular biomarkers and common pathways in lung cancer, TB, and COVID19, which provide understanding into the association of SARSCoV 2 to lung cancer and tuberculosis. Based on the compatible RNA-seq data, our research employed GREIN and NCBI's Gene Expression Omnibus (GEO) to perform differential gene expression analysis. Our study exploited three RNAseq datasets from the Gene Expression Omnibus (GEO) GSE171110, GSE89403, and GSE81089 to identify distinct relationships between differentially expressed genes (DEGs) in SARSCoV 2, tuberculosis, and lung cancer. We identified 30 common genes among SARSCoV 2, tuberculosis, and lung cancer (25 upregulated genes and 5 downregulated genes). We analyzed the following five databases: WikiPathway, KEGG, Bio Carta, Elsevier Pathway and Reactome. Using Cytohubba's MCC and Degree methods, We determined the top 15 hub genes resulting from the PPI interaction. These hub genes can serve as potential biomarkers, leading to novel treatment strategies for disorders under investigation. Transcription factors (TFs) and microRNAs (miRNAs) were identified as the molecules that control the differentially expressed genes (DEGs) of interest, either during transcription or after transcription. We identified 35 prospective therapeutic compounds that form significant differentially expressed genes (DEGs) in SARSCoV 2, lung cancer, and tuberculosis, which could potentially serve as medications. We hypothesized that the potential medications that emerged from this investigation may have therapeutic benefits.

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Expression profile of KIR3DS1/KIR3DL1 receptors in association with immunological responses in TB, HIV and HIV/TB infected patients

Cited by 2 publications

References 41 publications

Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations

Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations

Network biology and bioinformatics-based framework to identify the impacts of SARS-CoV-2 infections on lung cancer and tuberculosis

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