Expression patterns of proliferating cell nuclear antigen in trichloroacetic acid peeled skin

Abstract

This study was designed to investigate whether trichloroacetic acid (TCA) peeling induces cellular proliferation in human skin using an immunohistochemical method. A 40% TCA peel resulted in a greater number of proliferating cell nuclear antigen (PCNA)-immunopositive cells in the whole epidermis as compared with 60% TCA or phenol peels. This finding suggests that long-term and frequent TCA peelings of low concentration would require special attention for unexpected cutaneous lesions such as skin tumors.

Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: Prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations

“…56 In our cases, there were 7 instances of PD (15.2%; 3 AK and 4 BD), and only two recurred (4.3%; one AK and one BD) during the 1-year follow-up period. If we consider the current results and previous reports, 57 phenol peels would not cause tumorigenesis in CR cases.…”

Chemical peeling and microdermabrasion of the skin: Comparative immunohistological and ultrastructural studies

“…early and severe periodontitis, and/or esophageal, gastrointestinal and genital involvement [1,2]. KS results from recessive loss-of-function mutations of the KIND1 gene (now called FERMT1) that encodes the protein kindlin-1, a component of focal adhesions in epithelial cells [3]. KS results from recessive loss-of-function mutations of the KIND1 gene (now called FERMT1) that encodes the protein kindlin-1, a component of focal adhesions in epithelial cells [3].…”

“…Jessner's solution represents a combination of resorcinol, salicylic and lactic acids in a sufficient quantity of ethanol [1]. The application of chemical peelings and microdermabrasion is associated with morphological changes reminiscent of wound healing activities in the skin [3]. Microdermabrasion involves the physical abrading of the skin with a high-pressure flow of crystals [2].…”

Recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) could accelerate burn wound healing in hamster skin

“…Relative densities of positive reaction for those proteins were higher in the experimental group than in the control group. Researchers have suggested that rhGM-CSF induces other growth factors or cytokines in a paracrine manner and that these factors stimulate keratinocytes and fibroblasts (Yamamoto et al 2007;Haroon et al 1999).…”