Expression patterns of loricrin in various species and tissues

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation

“…This sequential activation is functionally important. For example, proteins such as transglutaminase and involucrin, which are involved in the early stages of di erentiation, are expressed in the immediate suprabasal layers Rice and Green, 1979), while loricrin, which is utilized late in di erentiation, is expressed later (Bickenbach et al, 1995;Hohl et al, 1991Hohl et al, , 1993. In spite of the importance in normal skin biology, the mechanisms that regulate gene expression during early versus late di erentiation are not well understood.…”

Small Proline-Rich Proteins Are Cross-Bridging Proteins in the Cornified Cell Envelopes of Stratified Squamous Epithelia

“…It is proposed that this scaffold may then serve as a template for the second ''reinforcement'' stage of CE assembly, a process that seems to vary widely between epithelial cell types. For example, loricrin is by far the most abundant reinforcement protein in epidermal CEs, yet it is poorly expressed in cultured keratinocytes, and it is absent in many internal epithelia (Hohl et al, 1991(Hohl et al, , 1993. Similarly, the amounts of the SPR proteins vary widely, from essentially absent in newborn and adult interfollicular human or rodent epidermis, to modest amounts in fetal periderm and neonatal human foreskin epidermis , to abundant amounts in mouse epidermis of the lip, snout, footpad, hair follicle, and rodent forestomach epithelium (Jarnik et al, 1996;Kartasova et al, 1996).…”

“…In all cases of the epidermis so far examined in detail, loricrin is the major component, accounting for as much as 80% of the total CE protein mass (Steven and Steinert, 1994;Steinert andMarekov, 1995, 1997;Yoneda and Steinert (1993). However, it is not expressed in most internal epithelia (Hohl et al, 1993). Similarly, the amounts of the SPR proteins vary from near zero in interfollicular epidermis to about 30% in certain epithelia or cultured keratinocytes Steven and Steinert, 1994;Jarnik et al, 1996).…”

Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology

“…Loricrin, one of the major components of the cornified cell envelope, is induced and strongly expressed at the later stage of epithelial differentiation (11)(12)(13). Several factors, such as loricrin, involucrin, sciellin, and small proline-rich proteins, have been implicated in this differentiation as precursor proteins of the cornified cell envelope (13)(14)(15)(16). There is limited information on the correlation between these cytoskeleton network genes and oral premalignant lesions (17).…”

“…Bloor et al (10) examined K2e/K10 expression in oral mucosal dysplasia and OSCC, and obtained data similar to our observations. Loricrin, one of the major components of the cornified cell envelope, is induced and strongly expressed at the later stage of epithelial differentiation (11)(12)(13). Several factors, such as loricrin, involucrin, sciellin, and small proline-rich proteins, have been implicated in this differentiation as precursor proteins of the cornified cell envelope (13)(14)(15)(16).…”