Expression Patterns of HIF-1α Under Hypoxia in Vascular Smooth Muscle Cells of Venous Malformations

Abstract

These results indicate that the high expression of HIF-1α in VM VSMCs under hypoxic conditions could be an important factor for stimulating downstream angiogenesis in VM. Furthermore, the results of this investigation could provide the basis for future studies of VM pathophysiology, and ultimately lead to the development of new therapeutic approaches.

Inhibitory effects of 17β-estradiol or a resveratrol dimer on hypoxia-inducible factor-1α in genioglossus myoblasts: Involvement of ERα and its downstream p38 MAPK pathways

“…The expression of hypoxia-regulated HIF-1α has been described to be altered along with time ( 34 , 35 ). Therefore, we detected the HIF-1α expression after 24, 48 and 72 h in the present study and observed a similar variation pattern of HIF-1α expression at those three time-points (data not shown).…”

Percutaneous sinus angiography and three-dimensional CT imaging showing morphological and draining features of venous malformations in soft tissue

“…1 The vessel wall of the dysplastic veins is thin and weak with the absence of smooth muscle cells 2 and abnormal expression of hypoxia-inducible factors. 3,4 The continuous expansion of abnormal veins may lead to the rupture of venous wall, the fusion of vein channels, and the formation of giant venous sinus. 5…”