Expression Patterns of CXCL12 and its Receptor in Colorectal Carcinoma

Mousavi, Ashraf Sadat; Hashemzadeh, Shahryar; Bahrami, Tayyeb; Estiar, Mehrdad Asghari; Feizi, Mohammad Ali Hosseinpour; Pouladi, Nasser; Rostamizadeh, Leila; Sakhinia, Ebrahim

doi:10.7754/clin.lab.2017.170913

Cited by 4 publications

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“…It was also considered as hub gene (Liang et al, 2016) and mRNA expression of CXCL12 was significantly correlated with rectal location (Yoshuantari, Heriyanto, Hutajulu, Kurnianda, & Ghozali, 2018). However, there were no significant differences for mRNA CXCL12 between tumor tissues and the adjacent nonaffected tissues (Mousavi et al, 2018). INSL5 (insulin-like 5) was a member of the insulin/relaxin superfamily.…”

Section: Validation and Survival Analysis Based On Tcga Databasementioning

confidence: 99%

Identification of differentially expressed genes and biological characteristics of colorectal cancer by integrated bioinformatics analysis

Sun

Peng

et al. 2019

Journal Cellular Physiology

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Colorectal cancer (CRC) ranks as one of the most common malignant tumors worldwide. Its mortality rate has remained high in recent years. Therefore, the aim of this study was to identify significant differentially expressed genes (DEGs) involved in its pathogenesis, which may be used as novel biomarkers or potential therapeutic targets for CRC. The gene expression profiles of GSE21510, GSE32323, GSE89076, and GSE113513 were downloaded from the Gene Expression Omnibus (GEO) database. After screening DEGs in each GEO data set, we further used the robust rank aggregation method to identify 494 significant DEGs including 212 upregulated and 282 downregulated genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed by DAVID and the KOBAS online database, respectively. These DEGs were shown to be significantly enriched in different cancer‐related functions and pathways. Then, the STRING database was used to construct the protein–protein interaction network. The module analysis was performed by the MCODE plug‐in of Cytoscape based on the whole network. We finally filtered out seven hub genes by the cytoHubba plug‐in, including PPBP, CCL28, CXCL12, INSL5, CXCL3, CXCL10, and CXCL11. The expression validation and survival analysis of these hub genes were analyzed based on The Cancer Genome Atlas database. In conclusion, the robust DEGs associated with the carcinogenesis of CRC were screened through the GEO database, and integrated bioinformatics analysis was conducted. Our study provides reliable molecular biomarkers for screening and diagnosis, prognosis as well as novel therapeutic targets for CRC.

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Section: Validation and Survival Analysis Based On Tcga Databasementioning

confidence: 99%

Identification of differentially expressed genes and biological characteristics of colorectal cancer by integrated bioinformatics analysis

Sun

Peng

et al. 2019

Journal Cellular Physiology

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“…In tumors, CXCL12 is expressed by epithelial cells but also by vascular endothelial cells [96] and stromal fibroblasts [97]. Finally, some studies observe no difference in expression between healthy mucosa and tumor [98]. In contrast, we showed that CXCL12 expression is strongly decreased in 94% of adenomas and 85% and 75% of MSI and MSS carcinomas, respectively [52].…”

Section: Cxcl12 Expressionmentioning

confidence: 76%

Clinical, Pathological, and Molecular Characteristics in Colorectal Cancer

2023

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Cover image courtesy of Stephane Dedieu© 2023 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND.

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“…In tumors, CXCL12 is expressed by epithelial cells but also by vascular endothelial cells [ 96 ] and stromal fibroblasts [ 97 ]. Finally, some studies observe no difference in expression between healthy mucosa and tumor [ 98 ]. In contrast, we showed that CXCL12 expression is strongly decreased in 94% of adenomas and 85% and 75% of MSI and MSS carcinomas, respectively [ 52 ].…”

Section: Cxcl12/cxcr4/cxcr7: Pathological Role In Crcmentioning

confidence: 99%

Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7

Goïta

Guénot

2022

Cancers

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Colorectal cancer is one of the most common cancers, and diagnosis at late metastatic stages is the main cause of death related to this cancer. This progression to metastasis is complex and involves different molecules such as the chemokine CXCL12 and its two receptors CXCR4 and CXCR7. The high expression of receptors in CRC is often associated with a poor prognosis and aggressiveness of the tumor. The interaction of CXCL12 and its receptors activates signaling pathways that induce chemotaxis, proliferation, migration, and cell invasion. To this end, receptor inhibitors were developed, and their use in preclinical and clinical studies is ongoing. This review provides an overview of studies involving CXCR4 and CXCR7 in CRC with an update on their targeting in anti-cancer therapies.

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Expression Patterns of CXCL12 and its Receptor in Colorectal Carcinoma

Cited by 4 publications

References 0 publications

Identification of differentially expressed genes and biological characteristics of colorectal cancer by integrated bioinformatics analysis

Identification of differentially expressed genes and biological characteristics of colorectal cancer by integrated bioinformatics analysis

Clinical, Pathological, and Molecular Characteristics in Colorectal Cancer

Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7

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