Expression pattern of the winged-helix/forkhead transcription factor Foxp1 in the developing central nervous system

Tamura, Shinobu; Morikawa, Yoshihiro; Iwanishi, Hiroki; Hisaoka, Tomoko; Senba, Emiko

doi:10.1016/s1567-133x(03)00003-6

Cited by 41 publications

(40 citation statements)

References 9 publications

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“…Many of the genes showing significant variation in specific brain regions in this data set have also been identified in other published reports on regional specificity. For example, we found significant variation in Foxp1, Actn2, and Rgs9 in the basal ganglia, in accordance with previous studies (Dunah et al 2000;Ferland et al 2003;Rahman et al 2003;Tamura et al 2003Tamura et al , 2004Zapala et al 2005). However, our data also expand previous studies and show that variation in gene expression in the brain is substantially higher than previously reported.…”

Section: Discussionsupporting

confidence: 92%

Large-Scale Gene Expression Differences Across Brain Regions and Inbred Strains Correlate With a Behavioral Phenotype

Nadler

Zou²,

Huang³

et al. 2006

Genetics

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Behaviors are often highly heritable, polygenic traits. To investigate molecular mediators of behavior, we analyzed gene expression patterns across seven brain regions (amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex, and olfactory bulb) of 10 different inbred mouse strains (129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBR T 1 tf/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, and FVB/NJ). Extensive variation was observed across both strain and brain region. These data provide potential transcriptional intermediates linking polygenic variation to differences in behavior. For example, mice from different strains had variable performance on the rotarod task, which correlated with the expression of .2000 transcripts in the cerebellum. Correlation with this task was also found in the amygdala and hippocampus, but not in other regions examined, indicating the potential complexity of motor coordination. Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression.

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Section: Discussionsupporting

confidence: 92%

Large-Scale Gene Expression Differences Across Brain Regions and Inbred Strains Correlate With a Behavioral Phenotype

Nadler

Zou²,

Huang³

et al. 2006

Genetics

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“…This corresponds to the in situ analyses performed in mice, where Foxp1, besides its expression in the lung, is also described in the developing central nervous system and in the intestine (Shu et al, 2001;Tamura et al, 2003). Thus, the relationship between the mammalian and Xenopus FoxP1 genes is not only reflected by sequence homology but also by similar expression patterns.…”

Section: A B C D E F G a Bsupporting

confidence: 75%

The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development

Pohl

Rossner²,

Knöchel

2005

Int. J. Dev. Biol.

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We here describe the sequences and expression patterns of three new Fox (fork head box) transcription factors in Xenopus laevis embryos. xlFoxI2, another member of subclass I, is maternally transcribed. Zygotic transcripts are first detected during neurulation and become localised to the dorsal part of epibranchial placodes. xlFoxM1 like xlFoxP1 are the first members of subclasses M and P described in Xenopus. Both genes are maternally expressed and transcripts are found during early cleavage stages in the animal blastomeres. xlFoxM1 is strongly upregulated during neurula stages and transcripts are localised in the neuroectoderm. Later, expression is found in the spinal cord, the rhombencephalon, the retina and in the branchial arches. xlFoxP1 is activated during organogenesis and is mainly expressed in the brain, head mesenchyme and in the splanchnic layer of the lateral plate mesoderm. KEY WORDS: X. laevis, embryogenesis, fork head/winged helix factor, expression patternFox (fork head box) transcription factors are involved in various signalling pathways and cell fate decisions throughout development. According to conserved amino acid residues at distinct positions within the winged helix domain, these factors are categorised into the subclasses A to Q (Kaestner et al., 2000).While for the mouse and human species, Fox family members from all subclasses have been reported, in the South African clawed frog, Xenopus laevis, currently only the subclasses A to L are known. Here we report the sequence and initial characterisation of two additional Xenopus laevis Fox gene family members, xlFoxM1 and xlFoxP1 and add xlFoxI2 as a new member to the already existing subclass I. We describe the full length cDNAs encoding these proteins and investigate the temporal and spatial expression patterns of corresponding genes by RT-PCR and by whole mount in situ hybridisations. Results and Discussion xlFoxI2The FoxI subclass is already known in different organisms to contain several members and has recently been analysed regarding the phylogenetic relationship inside the subclass based on the zebrafish members (Solomon et al., 2003). By searching in EST data bases we have found an IMAGE-clone (4084049), which covers the complete translated region of a FoxI subclass member in Xenopus laevis. Referring to the suggested terminology regardInt.

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“…Both are expressed in the developing brain, spinal cord, branchial arches, and eye (Tamura et al 2003;Pohl et al 2004;Bonkowsky and Chien 2005). All elements from dCNE families 461 and 464 are located in the introns of FOXP1 and FOXP2 in both human and Fugu.…”

Section: Functional Analysis Of Dcnesmentioning

confidence: 99%

Ancient duplicated conserved noncoding elements in vertebrates: A genomic and functional analysis

McEwen¹,

Woolfe²,

Goode³

et al. 2006

Genome Res.

100

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Fish-mammal genomic comparisons have proved powerful in identifying conserved noncoding elements likely to be cis-regulatory in nature, and the majority of those tested in vivo have been shown to act as tissue-specific enhancers associated with genes involved in transcriptional regulation of development. Although most of these elements share little sequence identity to each other, a small number are remarkably similar and appear to be the product of duplication events. Here, we searched for duplicated conserved noncoding elements in the human genome, using comparisons with Fugu to select putative cis-regulatory sequences. We identified 124 families of duplicated elements, each containing between two and five members, that are highly conserved within and between vertebrate genomes. In 74% of cases, we were able to assign a specific set of paralogous genes with annotation relating to transcriptional regulation and/or development to each family, thus removing much of the ambiguity in identifying associated genes. We find that duplicate elements have the potential to up-regulate reporter gene expression in a tissue-specific manner and that expression domains often overlap, but are not necessarily identical, between family members. Over two thirds of the families are conserved in duplicate in fish and appear to predate the large-scale duplication events thought to have occurred at the origin of vertebrates. We propose a model whereby gene duplication and the evolution of cis-regulatory elements can be considered in the context of increased morphological diversity and the emergence of the modern vertebrate body plan.

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Expression pattern of the winged-helix/forkhead transcription factor Foxp1 in the developing central nervous system

Cited by 41 publications

References 9 publications

Large-Scale Gene Expression Differences Across Brain Regions and Inbred Strains Correlate With a Behavioral Phenotype

Large-Scale Gene Expression Differences Across Brain Regions and Inbred Strains Correlate With a Behavioral Phenotype

The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development

Ancient duplicated conserved noncoding elements in vertebrates: A genomic and functional analysis

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