Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development

Bulfone, Alessandro; Marigo, Valeria; Campanella, Marilena; Basile, Andrea; Quaderi, Nandita; Gattuso, Claudio; Rubenstein, John L.R.; Ballabio, Andrea

doi:10.1016/s0925-4773(99)00053-2

Cited by 141 publications

(120 citation statements)

References 19 publications

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“…In the present study, we show that Tbr2, a T-domain transcription factor (TF) in the developing brain (Bulfone et al, 1999), is highly expressed in neuronal progenitors in the SVZ and basal VZ of neocortex, consistent with IPCs. We further demonstrate that Pax6 is substantially downregulated in most Tbr2 ϩ cells, and that, in turn, Tbr2 is reduced to undetectable levels in postmitotic projection neurons, which instead express Tbr1, another T-domain TF (Bulfone et al, 1995;Hevner et al, 2001).…”

Section: Introductionmentioning

confidence: 60%

See 1 more Smart Citation

Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

Englund¹,

Fink²,

Lau³

et al. 2005

J. Neurosci.

1,153

1,243

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Section: Introductionmentioning

confidence: 60%

“…Previous work showed that, in the embryonic neocortex, Tbr2 mRNA is initially expressed in the preplate and subsequently in proliferative zones (Bulfone et al, 1999). We hypothesized that Tbr2 ϩ cells in proliferative zones might be neuronal progenitor cells.…”

Section: Resultsmentioning

confidence: 89%

Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

Englund¹,

Fink²,

Lau³

et al. 2005

J. Neurosci.

1,153

1,243

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“…Tbr1 is expressed in the preplate and layer 6 during early corticogenesis [40], and Tbr1-deficient mice show defects in preplate splitting and in the positioning of early-born neurons (similar to the migration defects observed in reeler mice) [41]. Indeed, in the absence of Tbr1, the expression of reelin by Cajal-Retzius cells in the marginal zone is reduced [41].…”

Section: A Role For Sox5 In the Specification Of Distinct Subtypes Ofmentioning

confidence: 85%

“…However, the functional roles of these genes remains poorly understood. For example, the T-box gene Tbr2 is expressed prominently in the SVZ [40,42], but Tbr2 knockout mice die early at the blastocyst stage [43], precluding an analysis of Tbr2 function in cortical development.…”

Section: Mechanisms That Direct Upper Layer Neuronal Identitymentioning

confidence: 99%

The determination of projection neuron identity in the developing cerebral cortex

Leone

Srinivasan

Chen

et al. 2008

Current Opinion in Neurobiology

329

315

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Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neurons, which are found in the deep layers. Early progenitor cells in the ventricular zone produce deep layer neurons that express transcription factors including Sox5, Fezf2, and Ctip2, which play important roles in the specification of subcortically projecting axons. Upper layer neurons are produced from progenitors in the subventricular zone, and the expression of Satb2 in these differentiating neurons is required for the formation of axonal projections that connect the two cerebral hemispheres. The Fezf2/Ctip2 and Satb2 pathways appear to be mutually repressive, thus ensuring that individual neurons adopt either a subcortical or callosal projection neuron identity at early times during development. The molecular mechanisms by which Satb2 regulates gene expression involves long-term epigenetic changes in chromatin configuration, which may enable cell fate decisions to be maintained during development.

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“…The library has been optimized to detect rare or unique cDNAs, which correspond to genes that are expressed at levels from fivefold to 60-fold those in the embryonic telencephalon [embryonic day 14.5 (E14.5)] compared with the adult telencephalon (Porteus et al, 1992). This cDNA library was the source for the identification of various genes that have essential roles during embryogenesis (such as Dlx2, Tbr1, and eomes-Tbr2) (Porteus et al, 1991;Bulfone et al, 1995Bulfone et al, , 1999. We therefore decided to systematically characterize the TESS collection in a search for novel transcripts that, besides being preferentially expressed in the embryonic telencephalon, can be associated with the regulation of specific developmental processes (based on their regional and temporal patterns of expression; i.e., progenitor proliferation, cell-fate specification, differentiation, maturation, and survival) and with neuropsychiatric disorders of developmental origin.…”

Section: Introductionmentioning

confidence: 99%

Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes

Bulfone¹,

Carotenuto²,

Faedo³

et al. 2005

J. Neurosci.

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The vertebrate telencephalon is composed of many architectonically and functionally distinct areas and structures, with billions of neurons that are precisely connected. This complexity is fine-tuned during development by numerous genes. To identify genes involved in the regulation of telencephalic development, a specific subset of differentially expressed genes was characterized. Here, we describe a set of cDNAs encoded by genes preferentially expressed during development of the mouse telencephalon that was identified through a functional genomics approach. Of 832 distinct transcripts found, 223 (27%) are known genes. Of the remaining, 228 (27%) correspond to expressed sequence tags of unknown function, 58 (7%) are homologs or orthologs of known genes, and 323 (39%) correspond to novel rare transcripts, including 48 (14%) new putative noncoding RNAs. As an example of this latter group of novel precursor transcripts of micro-RNAs, telencephalic embryonic subtractive sequence (TESS) 24.E3 was functionally characterized, and one of its targets was identified: the zinc finger transcription factor ZFP9. The TESS transcriptome has been annotated, mapped for chromosome loci, and arrayed for its gene expression profiles during neural development and differentiation (in Neuro2a and neural stem cells). Within this collection, 188 genes were also characterized on embryonic and postnatal tissue by in situ hybridization, demonstrating that most are specifically expressed in the embryonic CNS. The full information has been organized into a searchable database linked to other genomic resources, allowing easy access to those who are interested in the dissection of the molecular basis of telencephalic development.

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Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development

Cited by 141 publications

References 19 publications

Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

The determination of projection neuron identity in the developing cerebral cortex

Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes

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