Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo

Homma, Shunsaku; Shimada, Takako; Hikake, Tsuyoshi; Yaginuma, Hiroyuki

doi:10.1016/j.gep.2008.09.004

Cited by 68 publications

(75 citation statements)

References 83 publications

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“…Previously, the expression of Gpr125 was reported in various tissues of mouse embryos and adults, including the pluripotent spermatogonial progenitor cells (Seandel et al, 2007;Homma et al, 2009;Pickering et al, 2008); however, its function was not known. Here, we have identified zebrafish Gpr125 as a novel modulator of C&E gastrulation movements and tangential FBMN migration, two processes evolutionarily conserved among vertebrates that require PCP signaling Gray et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

Roszko

Sepich

et al. 2013

Development

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SUMMARYDuring vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen them anteroposteriorly. Here, we have identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired C&E movements and the underlying cell and molecular polarities. Reduced Gpr125 function exacerbated the C&E and facial branchiomotor neuron (FBMN) migration defects of embryos with reduced Wnt/PCP signaling. At the molecular level, Gpr125 recruited Dishevelled to the cell membrane, a prerequisite for Wnt/PCP activation. Moreover, Gpr125 and Dvl mutually clustered one another to form discrete membrane subdomains, and the Gpr125 intracellular domain directly interacted with Dvl in pull-down assays. Intriguingly, Dvl and Gpr125 were able to recruit a subset of PCP components into membrane subdomains, suggesting that Gpr125 may modulate the composition of Wnt/PCP membrane complexes. Our study reveals a role for Gpr125 in PCP-mediated processes and provides mechanistic insight into Wnt/PCP signaling.

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Section: Discussionmentioning

confidence: 99%

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

Roszko

Sepich

et al. 2013

Development

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“…SALMs, also known as Lrfn (leucine-rich repeat and fibronectin III domain-containing), are a recently identified family of adhesion molecules that are largely, but not exclusively, restricted to neurons (5)(6)(7)(8). They are enriched in growth cones and then later at synapses, and changes in SALM expression alter neurite outgrowth and synapse formation (5,6,9,10).…”

Section: Cell Adhesion Molecules (Cams)mentioning

confidence: 99%

Dileucine and PDZ-binding Motifs Mediate Synaptic Adhesion-like Molecule 1 (SALM1) Trafficking in Hippocampal Neurons

Seabold

Wang

Petralia

et al. 2012

Journal of Biological Chemistry

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“…An amphibian peroxidasin is expressed during embryogenesis in specific organs, including the neural tube, otic vesicle, pronephros and tail-forming region (Tindall et al, 2005). By contrast, murine peroxidasin is more widely expressed (Homma et al, 2009). Human peroxidasin (PXDN) transcription is also widespread, whereas peroxidasin protein appears to be restricted to the cardiovascular system (Cheng et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

TheC. elegansperoxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration

et al. 2010

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SUMMARYPeroxidasins form a highly conserved family of extracellular peroxidases of unknown cellular function. We identified the C. elegans peroxidasin PXN-2 in screens for mutants defective in embryonic morphogenesis. We find that PXN-2 is essential for specific stages of embryonic morphogenesis and muscle-epidermal attachment, and is also required postembryonically for basement membrane integrity. The peroxidase catalytic activity of PXN-2 is necessary for these developmental roles. pxn-2 mutants display aberrant ultrastructure of the extracellular matrix, suggesting a role in basement membrane consolidation. PXN-2 affects specific axon guidance choice points in the developing nervous system but is dispensable for maintenance of process positions. In adults, loss of pxn-2 function promotes regrowth of axons after injury, providing the first evidence that C. elegans extracellular matrix can play an inhibitory role in axon regeneration. Loss of function in the closely related C. elegans peroxidasin pxn-1 does not cause overt developmental defects. Unexpectedly, pxn-2 mutant phenotypes are suppressed by loss of function in pxn-1 and exacerbated by overexpression of wild-type pxn-1, indicating that PXN-1 and PXN-2 have antagonistic functions. These results demonstrate that peroxidasins play crucial roles in development and reveal a new role for peroxidasins as extracellular inhibitors of axonal regeneration.

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Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo

Cited by 68 publications

References 83 publications

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling

Dileucine and PDZ-binding Motifs Mediate Synaptic Adhesion-like Molecule 1 (SALM1) Trafficking in Hippocampal Neurons

TheC. elegansperoxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration

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