Expression pattern of glypican-1 mRNA after brain injury in mice

Hagino, Seita; Iseki, Ken; Mori, Tetsuji; Zhang, Yuxiang; Sakai, Norisuke; Yokoya, Sachihiko; Hikake, Tsuyoshi; Kikuchi, Shinichi; Wanaka, Akio

doi:10.1016/s0304-3940(03)00690-6

Cited by 21 publications

(18 citation statements)

References 14 publications

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“…This leads to a positive feedback loop, as HS potentiates the activity of TGF-β1 (Lee et al 2015a) and TGF-β increases the synthesis of both HSPGs and CSPGs (Dodge et al 1990; Sugimoto et al 2014). Cryoinjury produces an upregulation of glypican mRNA (Hagino et al 2003b), suggesting a role for glypican in the neuroimmune response, but there is no direct demonstration of a role for glypicans in TBI.…”

Section: Proteoglycansmentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

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The Brain Extracellular Matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following Traumatic Brain Injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.

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Section: Proteoglycansmentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

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“…FGF2 co-localizes with several chemical forms of amyloid. Neuronal coexistence of FGF2 and amyloid precursor protein (APP) [64,65] intimates a functional relationship between FGF2 and APP, perhaps in post-injury regeneration. FGF2 also minimizes metabolic injury caused by Aβ peptides.…”

Section: Reviewmentioning

confidence: 99%

Untitled

Johanson

McMillan

Tavares

et al. 2004

Cerebrospinal Fluid Res

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As the secretory source of vitamins, peptides and hormones for neurons, the choroid plexus (CP) epithelium critically provides substances for brain homeostasis. This distributive process of cerebrospinal fluid (CSF) volume transmission reaches many cellular targets in the CNS. In ageing and ageing-related dementias, the CP-CSF system is less able to regulate brain interstitial fluid. CP primarily generates CSF bulk flow, and so its malfunctioning exacerbates Alzheimers disease (AD). Considerable attention has been devoted to the blood-brain barrier in AD, but more insight is needed on regulatory systems at the human blood-CSF barrier in order to improve epithelial function in severe disease. Using autopsied CP specimens from AD patients, we immunocytochemically examined expression of heat shock proteins (HSP90 and GRP94), fibroblast growth factor receptors (FGFr) and a fluid-regulatory protein (NaK2Cl cotransporter isoform 1 or NKCC1). CP upregulated HSP90, FGFr and NKCC1, even in end-stage AD. These CP adjustments involve growth factors and neuropeptides that help to buffer perturbations in CNS water balance and metabolism. They shed light on CP-CSF system responses to ventriculomegaly and the altered intracranial pressure that occurs in AD and normal pressure hydrocephalus. The ability of injured CP to express key regulatory proteins even at Braak stage V/VI, points to plasticity and function that may be boosted by drug treatment to expedite CSF dynamics. The enhanced expression of human CP 'homeostatic proteins' in AD dementia is discussed in relation to brain deficits and pharmacology.

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“…study of freshly sorted mouse NG2 glia [131] Synaptic plasticity [141] Glypican 5, Gpc5 Gene expr. study of freshly sorted mouse NG2 glia [131] Neuronal plasticity [142,143] Gene expr. study of freshly sorted mouse NG2 glia [131] Blood vessel maintenance [144] Syndecan 3, sdc3 Gene expr.…”

Section: Growth Factorsmentioning

confidence: 99%

NG2 Glia: Novel Roles beyond Re-/Myelination

Parolisi

Boda

2018

Neuroglia

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Neuron-glia antigen 2-expressing glial cells (NG2 glia) serve as oligodendrocyte progenitors during development and adulthood. However, recent studies have shown that these cells represent not only a transitional stage along the oligodendroglial lineage, but also constitute a specific cell type endowed with typical properties and functions. Namely, NG2 glia (or subsets of NG2 glia) establish physical and functional interactions with neurons and other central nervous system (CNS) cell types, that allow them to constantly monitor the surrounding neuropil. In addition to operating as sensors, NG2 glia have features that are expected for active modulators of neuronal activity, including the expression and release of a battery of neuromodulatory and neuroprotective factors. Consistently, cell ablation strategies targeting NG2 glia demonstrate that, beyond their role in myelination, these cells contribute to CNS homeostasis and development. In this review, we summarize and discuss the advancements achieved over recent years toward the understanding of such functions, and propose novel approaches for further investigations aimed at elucidating the multifaceted roles of NG2 glia.

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Expression pattern of glypican-1 mRNA after brain injury in mice

Cited by 21 publications

References 14 publications

Extracellular matrix and traumatic brain injury

Extracellular matrix and traumatic brain injury

Untitled

NG2 Glia: Novel Roles beyond Re-/Myelination

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