Expression Pattern Implicates a Potential Role for Luman Recruitment Factor in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice

Yang, Yanzhou; Jin, Yaping; Martyn, Amanda C.; Lin, Peng; Song, Yujie; Chen, Fenglei; Hu, Linyong; Cui, Chenchen; Xiao, Li; Li, Qian; Lu, Ray; Wang, Aihua

doi:10.1262/jrd.2012-137

Cited by 23 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the function of CREBRF is minimally characterized, so the mechanisms by which rs373863828 affects these phenotypes are currently unclear. Individual studies have indicated that this transcription factor impacts glucocorticoid signaling, autophagy, unfolded protein response, and starvation resistance, as well as murine decidualization, embryo implantation, and maternal behavior (Audas, Li, Liang, & Lu, 2008; Li et al, 2016; Martyn et al, 2012; Minster et al, 2016; Xue et al, 2016; Yang et al, 2013). Future studies should aim to refine the effect of this variation on the related phenotypes of height, weight, and BMI in other Pacific Island populations, as well as other anthropometric traits.…”

Section: Discussionmentioning

confidence: 99%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2019

Preprint

View full text Add to dashboard Cite

ObjectivesStudies have demonstrated that rs373863828, a missense mutation in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to a previously untested association of this variant with height.MethodsWe tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5 - 18 years old) using linear mixed modeling.ResultsWe found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm greater average height for each copy of the minor allele) with the same direction of effect in Samoan children.ConclusionsThese results suggest that the missense variant rs373863828 in CREBRF, first identified through an association with larger BMI, may be related to an underlying biological mechanism affecting overall body size including stature.

show abstract

Section: Discussionmentioning

confidence: 99%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In contrast, the knowledge on the role of LRF in pregnancy is scarce. Only one study has been published 34 , reporting the expression of LRF specifically at implantation sites in mouse uterus, low levels of LRF in uteri of mice with delayed implantation and a cross-talk of LRF with steroid hormones such as progesterone and estradiol.…”

Section: Discussionmentioning

confidence: 99%

Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes

Sõber

Reiman

Kikas

et al. 2015

Sci Rep

116

View full text Add to dashboard Cite

One in five pregnant women suffer from gestational complications, prevalently driven by placental malfunction. Using RNASeq, we analyzed differential placental gene expression in cases of normal gestation, late-onset preeclampsia (LO-PE), gestational diabetes (GD) and pregnancies ending with the birth of small-for-gestational-age (SGA) or large-for-gestational-age (LGA) newborns (n = 8/group). In all groups, the highest expression was detected for small noncoding RNAs and genes specifically implicated in placental function and hormonal regulation. The transcriptome of LO-PE placentas was clearly distinct, showing statistically significant (after FDR) expressional disturbances for hundreds of genes. Taqman RT-qPCR validation of 45 genes in an extended sample (n = 24/group) provided concordant results. A limited number of transcription factors including LRF, SP1 and AP2 were identified as possible drivers of these changes. Notable differences were detected in differential expression signatures of LO-PE subtypes defined by the presence or absence of intrauterine growth restriction (IUGR). LO-PE with IUGR showed higher correlation with SGA and LO-PE without IUGR with LGA placentas. Whereas changes in placental transcriptome in SGA, LGA and GD cases were less prominent, the overall profiles of expressional disturbances overlapped among pregnancy complications providing support to shared placental responses. The dataset represent a rich catalogue for potential biomarkers and therapeutic targets.

show abstract

“…Mouse models of early pregnancy, pseudopregnancy, delayed implantation and activation, artificial decidualisation and hormonal treatment were produced as described in our previous reports [15,16]. Eight mice were used in each stage or treatment in this study.…”

Section: Methodsmentioning

confidence: 99%

CREBZF expression and hormonal regulation in the mouse uterus

Lin

Chen

Wang

et al. 2013

Reprod Biol Endocrinol

Self Cite

View full text Add to dashboard Cite

BackgroundCREBZF is a member of the mammalian ATF/CREB family of the basic region-leucine zipper (bZIP) transcription factors. Two isoforms of CREBZF have been identified from the alternative usage of initiation codons, SMILE (long isoform of CREBZF) and Zhangfei (short isoform of CREBZF). Until recently, the physiological function of CREBZF in mammalian reproductions has not been reported.MethodsMultiple techniques were performed to investigate the spatiotemporal expression and hormonal regulation of the CREBZF gene in the mouse uterus and its role in embryo implantation.ResultsZhangfei was not detected in the mouse uterus. SMILE immunostaining was mainly expressed in the uterine luminal and glandular epithelium, and the expression levels of both SMILE mRNA and protein gradually decreased from days 1–3 of pregnancy, peaked on day 4, and then declined again on day 6. On day 5 of pregnancy, SMILE protein expression was detected only in the luminal epithelium at implantation sites compared with the expression at inter-implantation sites. SMILE protein was not detected in decidual cells from days 6–8 of pregnancy or artificial decidualisation. Furthermore, SMILE protein was not detected in the mouse uterus on days 3–6 of pseudopregnancy, and SMILE expression was also induced in the delayed-implantation uterus, indicating that the presence of an active blastocyst was required for SMILE expression at the implantation site. Oestrogen significantly stimulated SMILE expression in the ovariectomised mouse uterus. In addition, in cycling mice, high levels of SMILE protein and mRNA expression were also observed in proestrus and oestrus uteri.ConclusionsTaken together, these results suggested that SMILE expression was closely related to mouse implantation and up-regulated by oestrogen.

show abstract

Expression Pattern Implicates a Potential Role for Luman Recruitment Factor in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice

Cited by 23 publications

References 34 publications

A missense variant in CREBRF is associated with taller stature in Samoans

A missense variant in CREBRF is associated with taller stature in Samoans

Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes

CREBZF expression and hormonal regulation in the mouse uterus

Contact Info

Product

Resources

About