Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer

Chiang, Chien-Ping; Jao, Shu-Wen; Lee, Shiao-Pieng; Chen, Pei-Chi; Chung, Chia-Chi; Lee, Shou-Lun; Nieh, Shin; Yin, Shih‐Jiun

doi:10.1016/j.alcohol.2011.08.004

Cited by 41 publications

(35 citation statements)

References 48 publications

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“…This is because the normalized active sites of heterotetramers relative to that of the normal homotetramers without correction for 50% shorter half-life, 0.25, are not quite far from that predicted with the correction (0.16). For human tissue ALDH2 contents in normal homozygotes, immunotitration studies using the class-specific purified ALDH2 antibodies have revealed the following decreasing order: liver (1,770 AE 140 lg/g tissue; n = 17) (this study), jejunal mucosa (163 AE 11 lg/g; n = 7) (Chiang et al, 2012b), pancreas (130 AE 25 lg/g; n = 5) (Chiang et al, 2009), duodenal mucosa (93.0 AE 8.5 lg/g; n = 7) (Chiang et al, 2012b), and rectal mucosa (24.2 AE 5.3 lg/g; n = 9) (Chiang et al, 2012a), indicating that liver is the primary site for conversion of acetaldehyde to acetate in the human body during EtOH metabolism.…”

Section: Discussionmentioning

confidence: 98%

“…Pharmacokinetic and pharmacodynamic studies support the notion that differing impairments of hepatic acetaldehyde metabolism between ALDH2*2 homozygotes and heterozygotes after alcohol intake can largely explain differential protections against alcoholism with regard to the ALDH2*2 allelic status (Chen et al, 1999b;Peng et al, 1999Peng et al, , 2007 and that heterozygous alcoholics overcoming acetaldehyde-induced aversive reactions may be attributed to physiological tolerance and/or innate insensitivity rather than an adapted acetaldehyde metabolism (Chen et al, 2009a). Recently, ALDH2 deficiency has also been associated with the increased risks of esophageal and colorectal cancer (Brooks et al, 2009;Chiang et al, 2012a) as well as a reduced efficacy of nitroglycerin (Chen and Stamler, 2006), whereas activation of ALDH2 may reduce the ischemia reperfusion cardiac injury (Chen et al, 2008).…”

mentioning

confidence: 89%

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Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver

Lai

Yao

Chau

et al. 2013

Alcohol Clin Exp Res

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 89%

Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver

Lai

Yao

Chau

et al. 2013

Alcohol Clin Exp Res

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“…However, the results have been inconsistent (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The present comprehensive meta-analysis of currently published studies aimed to identify the relationships between the ADH1B and ALDH2 polymorphisms and the risk of CRC.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the ADH1B and ALDH2 Polymorphisms and the Risk of Colorectal Cancer in East Asians

Guo

Wang

et al. 2013

Intern. Med.

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Objective The aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes have been implicated in the development of colorectal cancer (CRC). However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 and ADH1B polymorphisms and the risk of CRC. Methods Relevant studies were identified using PubMed, Web of Science and CNKI up to February, 2013. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using the fixed-or randomeffects model. Results A total of 11 case-controlled studies were selected. Of these, 11 studies included 2,893 cases and 3,817 controls concerning the ALDH2 Glu487Lys polymorphism and six studies included 1,864 cases and 3,502 controls concerning the ADH1B polymorphism. The results indicated that there was a statistically significant link between the ALDH2 polymorphism and the risk of CRC (Glu/Lys+Lys/Lys vs. Glu/Glu: OR= 0.87, 95%CI: 0.78-0.96, p=0.10; Glu/Lys vs. Glu/Glu: OR=0.87, 95%CI: 0.77-0.97, p=0.38); however, no significant associations were observed between the ADH1B polymorphism and the risk of CRC win any of the genetic models. Conclusion This meta-analysis demonstrated that the ALDH2 polymorphism, but not the ADH1B polymorphism, significantly increases the risk of CRC in East Asians.

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“…For example, acetaldehyde is produced in the epithelium by mucosal ALDH 2 , while higher levels are derived from microbial oxidation of ethanol by oral microflora such as Candida species 9 , 10 , 12 , 17 , 23 . Thus, the effects of acetaldehyde on the oral cavity can be local, and oral hygiene may be linked to local production of acetaldehyde by oral microflora.…”

Section: Introductionmentioning

confidence: 99%

Relationship between acetaldehyde concentration in mouth air and tongue coating volume

et al. 2015

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Objective Acetaldehyde is the first metabolite of ethanol and is produced in the epithelium by mucosal ALDH, while higher levels are derived from microbial oxidation of ethanol by oral microflora such as Candida species. However, it is uncertain whether acetaldehyde concentration in human breath is related to oral condition or local production of acetaldehyde by oral microflora. The aim of this pilot study was to investigate the relationship between physiological acetaldehyde concentration and oral condition in healthy volunteers.Material and Methods Sixty-five volunteers (51 males and 14 females, aged from 20 to 87 years old) participated in the present study. Acetaldehyde concentration in mouth air was measured using a portable monitor. Oral examination, detection of oral Candida species and assessment of alcohol sensitivity were performed.Results Acetaldehyde concentration [median (25%, 75%)] in mouth air was 170.7 (73.5, 306.3) ppb. Acetaldehyde concentration in participants with a tongue coating status score of 3 was significantly higher than in those with a score of 1 (p<0.017). After removing tongue coating, acetaldehyde concentration decreased significantly (p<0.05). Acetaldehyde concentration was not correlated with other clinical parameters, presence of Candida species, smoking status or alcohol sensitivity.Conclusion Physiological acetaldehyde concentration in mouth air was associated with tongue coating volume.

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Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer

Cited by 41 publications

References 48 publications

Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver

Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver

Meta-analysis of the ADH1B and ALDH2 Polymorphisms and the Risk of Colorectal Cancer in East Asians

Relationship between acetaldehyde concentration in mouth air and tongue coating volume

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