Expression of β1- and β2-adrenoceptors in different subtypes of interneurons in the medial prefrontal cortex of mice

Liu, Y.; Liang, Xinyu; Ren, Weishu; Li, B.-M.

doi:10.1016/j.neuroscience.2013.10.078

Cited by 19 publications

(20 citation statements)

References 37 publications

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“…NE enhances the excitability of many types of GABAergic interneurons through up-regulation of the somatodendritic K + channels via activation of α but not β receptors (Bennett et al, 1998; Kawaguchi and Shindou, 1998). However, a recent study has found that both β 1 and β 2 receptors are expressed, albeit differently, in a majority of GABAergic interneurons in mouse PFC, indicating a potential role of β receptors in modulating different cortical interneuron populations (Liu et al, 2014). Interestingly, NE triggers spike firing only in a subset of interneurons such as somatostatin (SST)-containing cells and cholecystokinin (CCK)-positive interneurons, but not in FS and late-spiking interneurons (Bennett et al, 1998).…”

Section: Ne and Da Modulation Of Synaptic Transmission In The Pfc mentioning

confidence: 99%

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

2016

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Among the neuromodulators that regulate prefrontal cortical circuit function, the catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful players in working memory and attention. Perturbation of either NE or DA signaling is implicated in the pathogenesis of several neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), schizophrenia, and drug addiction. Although the precise mechanisms employed by NE and DA to cooperatively control prefrontal functions are not fully understood, emerging research indicates that both transmitters regulate electrical and biochemical aspects of neuronal function by modulating convergent ionic and synaptic signaling in the prefrontal cortex (PFC). This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical circuitry. Specifically, we focus on the functional interaction between NE and DA in prefrontal cortical local circuitry, synaptic integration, signaling pathways, and receptor properties. Although it is clear that both NE and DA innervate the PFC extensively and modulate synaptic function by activating distinctly different receptor subtypes and signaling pathways, it remains unclear how these two systems coordinate their actions to optimize PFC function for appropriate behavior. Throughout this review, we provide perspectives and highlight several critical topics for future studies.

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Section: Ne and Da Modulation Of Synaptic Transmission In The Pfc mentioning

confidence: 99%

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

2016

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“…βRs are, in fact, expressed in both excitatory and inhibitory cells in the cortex as well as in subcortical nuclei (Cox et al, 2008; Salgado et al, 2011; Liu et al, 2014). Among the latter, the amygdala is endowed with an especially high βRs density (Abraham et al, 2008).…”

Section: βRs Central Modulationmentioning

confidence: 99%

Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?

Atzori

Cuevas-Olguín

Esquivel-Rendón

et al. 2016

Front. Synaptic Neurosci.

116

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Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from where it is released by axonal varicosities throughout the brain via volume transmission. A wealth of data from clinics and from animal models indicates that this catecholamine coordinates the activity of the central nervous system (CNS) and of the whole organism by modulating cell function in a vast number of brain areas in a coordinated manner. The ubiquity of NE receptors, the daunting number of cerebral areas regulated by the catecholamine, as well as the variety of cellular effects and of their timescales have contributed so far to defeat the attempts to integrate central adrenergic function into a unitary and coherent framework. Since three main families of NE receptors are represented—in order of decreasing affinity for the catecholamine—by: α2 adrenoceptors (α2Rs, high affinity), α1 adrenoceptors (α1Rs, intermediate affinity), and β adrenoceptors (βRs, low affinity), on a pharmacological basis, and on the ground of recent studies on cellular and systemic central noradrenergic effects, we propose that an increase in LC tonic activity promotes the emergence of four global states covering the whole spectrum of brain activation: (1) sleep: virtual absence of NE, (2) quiet wake: activation of α2Rs, (3) active wake/physiological stress: activation of α2- and α1-Rs, (4) distress: activation of α2-, α1-, and β-Rs. We postulate that excess intensity and/or duration of states (3) and (4) may lead to maladaptive plasticity, causing—in turn—a variety of neuropsychiatric illnesses including depression, schizophrenic psychoses, anxiety disorders, and attention deficit. The interplay between tonic and phasic LC activity identified in the LC in relationship with behavioral response is of critical importance in defining the short- and long-term biological mechanisms associated with the basic states postulated for the CNS. While the model has the potential to explain a large number of experimental and clinical findings, a major challenge will be to adapt this hypothesis to integrate the role of other neurotransmitters released during stress in a centralized fashion, like serotonin, acetylcholine, and histamine, as well as those released in a non-centralized fashion, like purines and cytokines.

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“…However, inhibitory effects of α-adrenoreceptors have been observed in discrete subpopulations of CCK+ and SOM+ interneurons (Kawaguchi and Shindou, 1998), whether or not this inhibitory effect of α-adrenoreceptors is existent in CR+ bipolar interneurons remains unknown. β 1- and β 2-adrenoreceptors are not as frequently expressed in CR+ interneurons as compared to other types of interneurons (Liu et al, 2014). …”

Section: Synaptic Inputsmentioning

confidence: 99%

Revisiting enigmatic cortical calretinin-expressing interneurons

et al. 2014

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Cortical calretinin (CR)-expressing interneurons represent a heterogeneous subpopulation of about 10–30% of GABAergic interneurons, which altogether total ca. 12–20% of all cortical neurons. In the rodent neocortex, CR cells display different somatodendritic morphologies ranging from bipolar to multipolar but the bipolar cells and their variations dominate. They are also diverse at the molecular level as they were shown to express numerous neuropeptides in different combinations including vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK), neurokinin B (NKB) corticotrophin releasing factor (CRF), enkephalin (Enk) but also neuropeptide Y (NPY) and somatostatin (SOM) to a lesser extent. CR-expressing interneurons exhibit different firing behaviors such as adapting, bursting or irregular. They mainly originate from the caudal ganglionic eminence (CGE) but a subpopulation also derives from the dorsal part of the medial ganglionic eminence (MGE). Cortical GABAergic CR-expressing interneurons can be divided in two main populations: VIP-bipolar interneurons deriving from the CGE and SOM-Martinotti-like interneurons originating in the dorsal MGE. Although bipolar cells account for the majority of CR-expressing interneurons, the roles they play in cortical neuronal circuits and in the more general metabolic physiology of the brain remained elusive and enigmatic. The aim of this review is, firstly, to provide a comprehensive view of the morphological, molecular and electrophysiological features defining this cell type. We will, secondly, also summarize what is known about their place in the cortical circuit, their modulation by subcortical afferents and the functional roles they might play in neuronal processing and energy metabolism.

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Expression of β1- and β2-adrenoceptors in different subtypes of interneurons in the medial prefrontal cortex of mice

Cited by 19 publications

References 37 publications

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?

Revisiting enigmatic cortical calretinin-expressing interneurons

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