Expression of β‐1,4‐galactosyltransferase I in rat Schwann cells

Yang, Huiling; Yan, Ming; Cheng, Chun; Jiang, Jing; Zhang, Lili; Liu, Jie; Zhou, Zhengming; Shen, Aiguo

doi:10.1002/jcb.22229

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…And it was reported that Schwann cells regulated b-1,4-GalT-I expression after LPS stimulation via ERK, JNK, and P38 MAP kinase signal pathways (Yang et al 2009). Therefore, it was an important question whether LPS induced activation of ERK, p38, and JNK was related to b-1,4-GalT-I expression in rat primary astrocytes.…”

Section: Discussionmentioning

confidence: 97%

The Relationship Between Src-Suppressed C Kinase Substrate and β-1,4 Galactosyltransferase-I in the Process of Lipopolysaccharide-Induced TNF-α Secretion in Rat Primary Astrocytes

Shao

Yang

et al. 2011

Cell Mol Neurobiol

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Src-suppressed C kinase substrate (SSeCKS), a protein kinase C substrate, is a major lipopolysaccharide (LPS) response protein. In addition, β-1,4 Galactosyltransferase-I (β-1,4-GalT-I) also plays an important role in the inflammation reactions of nervous system. It was reported that both SSeCKS and β-1,4-GalT-I were involved in the LPS-induced tumor necrosis factor-alpha (TNF-α) expression in rat primary astrocytes. However, the functional interaction between SSeCKS and β-1,4-GalT-I in the LPS-induced TNF-α secretion remains unclear. Therefore, in this study, using the inflammation model of astrocytes treated by LPS in vitro, we found that the changed expressions of SSeCKS and β-1,4-GalT-I participated in LPS-induced TNF-α secretion through p38, JNK, and ERK signal transduction pathways in rat primary astrocytes. Knockdown by small-interfering RNAs (siRNAs) or overexpression of SSeCKS and β-1,4-GalT-I could influence Mitogen-activated protein kinases (MAPKs) signaling pathways activation and TNF-α secretion. Besides, we confirmed that knockdown of SSeCKS could prevent the induction of β-1,4-GalT-I in this process. Inversely, β-1,4-GalT-I had no significant effect on SSeCKS expression in the same way. In summary, our data indicated that SSeCKS could regulate LPS-induced TNF-α secretion through β-1,4-GalT-I in rat primary astrocytes.

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Section: Discussionmentioning

confidence: 97%

The Relationship Between Src-Suppressed C Kinase Substrate and β-1,4 Galactosyltransferase-I in the Process of Lipopolysaccharide-Induced TNF-α Secretion in Rat Primary Astrocytes

Shao

Yang

et al. 2011

Cell Mol Neurobiol

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“…Thus, different ABO blood types show different activities of glycosyltransferases. Glycosyltransferases were reported in significant repair and regeneration in nerve injury, via glycosylation of glycoproteins in Schwann cells [48, 49]. Moreover, glycosyltransferases are also involved in neuroinflammatory response [50].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Preoperative Anxiety and ABO Blood Types: Evidence from a Clinical Cross-Sectional Study

Yin

Xiong

et al. 2019

Disease Markers

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Gene-environment interaction is identified as the determinant in anxiety. ABO blood types represent a part of the genetic phenotype. Therefore, we assume ABO blood types correlate with preoperative anxiety. This cross-sectional study enrolled 352 patients with different ABO blood types, scheduled for elective surgery between 2018 and 2019 in the First Affiliated Hospital of Shihezi University. HADS (hospital anxiety and depression scale) scores and VA (visual analogue scales for anxiety) scores were all used to assess the preoperative anxiety in the A, B, AB, and O groups. Bivariate correlation and logistic regression were performed to identify relationships between preoperative anxiety and related variables. A significant difference in VA and HADS-A (anxiety) scores was found between the AB and other groups. The ratio of preoperative anxiety was 3.73 (95% CI [confidence interval]: 2.32-6.00, P < 0.001) times in female than in male; 0.36 (95% CI: 0.21-0.63, P < 0.001) times in ASA (American Society of Anesthesiologists) grade II than in grade I; 0.41 (95% CI: 0.20-0.86, P < 0.05) times in ASA grade III than in grade I; 1.25 (95% CI: 1.1-1.41, P < 0.001) times in higher VAS (visual analogue scales for pain) scores than in lower VAS scores; and 0.28 (95% CI: 0.16-0.49, P < 0.01) times in non-AB blood type than in AB blood type. Differences in ABO blood types were found in preoperative anxiety, and the AB group displayed a high preoperative anxiety level. ABO blood types, sex, ASA grade, and VAS were associated with preoperative anxiety. This trial is registered with ChiCTR1800019390.

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“…In support of our proposal, AA induces Src activation [Navarro‐Tito et al, 2008], and we demonstrate that Src mediates ERK1/2 activation, whereas ERK1/2 activity mediates the increase of GalT I expression induced by AA in MDA‐MB‐231 cells. Furthermore, an overexpression of ERK1 promotes an increase of GalT I expression in PGLH7 human lung cancer cells [Zhu et al, 2005], whereas ERK activity mediates GalT I expression in rat Schwann cells [Yang et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Arachidonic acid induces an increase of β‐1,4‐galactosyltransferase I expression in MDA‐MB‐231 breast cancer cells

Villegas-Comonfort

Serna-Márquez

Galindo-Hernández

et al. 2012

J of Cellular Biochemistry

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Arachidonic acid (AA) is a common dietary n-6 cis polyunsaturated fatty acid that under physiological conditions is present in an esterified form in cell membrane phospholipids, and it might be present in the extracellular microenvironment. AA and its metabolites are implicated in FAK activation and cell migration in MDA-MB-231 breast cancer cells, and an epithelial-to-mesenchymal-like transition process in mammary non-tumorigenic epithelial cells MCF10A. During malignant transformation is present an altered expression of glycosiltransferases, which promote changes on the glycosilation of cell-surface proteins. The β-1,4-galactosyltransferase I (GalT I) is an enzyme that participates in a variety of biological functions including cell growth, migration, and spreading. However, the participation of AA in the regulation of GalT I expression and the role of this enzyme in the cell adhesion process in breast cancer cells remains to be investigated. In the present study, we demonstrate that AA induces an increase of GalT I expression through a PLA2α, Src, ERK1/2, and LOXs activities-dependent pathway in MDA-MB-231 breast cancer cells. Moreover, MDA-MB-231 cells adhere to laminin via GalT I expression and pretreatment of cells with AA induces an increase of cell adhesion to laminin. In conclusion, our findings demonstrate, for the first time, that AA promotes an increase of GalT I expression through an AA metabolism, Src and ERK1/2 activities-dependent pathway, and that GalT I plays a pivotal role in cell adhesion to laminin in MDA-MB-231 breast cancer cells.

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Expression of β‐1,4‐galactosyltransferase I in rat Schwann cells

Cited by 6 publications

References 38 publications

The Relationship Between Src-Suppressed C Kinase Substrate and β-1,4 Galactosyltransferase-I in the Process of Lipopolysaccharide-Induced TNF-α Secretion in Rat Primary Astrocytes

The Relationship Between Src-Suppressed C Kinase Substrate and β-1,4 Galactosyltransferase-I in the Process of Lipopolysaccharide-Induced TNF-α Secretion in Rat Primary Astrocytes

Correlation between Preoperative Anxiety and ABO Blood Types: Evidence from a Clinical Cross-Sectional Study

Arachidonic acid induces an increase of β‐1,4‐galactosyltransferase I expression in MDA‐MB‐231 breast cancer cells

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