Expression of YAP and TAZ in molluscum contagiosum virus infected skin

Seo, Hyun-Min; Moon, Gue-Tae; Song, Yang; Gee, Heon Yung; Park, Y.M.; Lee, J.Y.; Lee, J.H.

doi:10.1111/bjd.16333

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Accumulating evidence shows that a variety of human viruses exert their carcinogenic function via the Hippo pathway ( 21 ). Known mechanisms of Hippo dysregulation in virus-infected cells include 1) up-regulation of YAP expression through activating its promoter ( 22 – 24 ), 2) inhibition of proteasome-dependent degradation of YAP protein ( 25 , 26 ), 3) inhibition of YAP phosphorylation to increase nuclear localization ( 26 , 27 ), and 4) suppression of the Hippo pathway through regulating the kinase activity of MST1/2 or LATS1/2 ( 28 ).…”

mentioning

confidence: 99%

HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis

Zhao

Wang

Fang

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) infection. HTLV-1 exerts its oncogenic functions by interacting with signaling pathways involved in cell proliferation and transformation. Dysregulation of the Hippo/YAP pathway is associated with multiple cancers, including virus-induced malignancies. In the present study, we observe that expression of YAP, which is the key effector of Hippo signaling, is elevated in ATL cells by the action of the HTLV-1 Tax protein. YAP transcriptional activity is remarkably enhanced in HTLV-1–infected cells and ATL patients. In addition, Tax activates the YAP protein via a mechanism involving the NF-κB/p65 pathway. As a mechanism for this cross talk between the Hippo and NF-κB pathways, we found that p65 abrogates the interaction between YAP and LATS1, leading to suppression of YAP phosphorylation, inhibition of ubiquitination-dependent degradation of YAP, and YAP nuclear accumulation. Finally, knockdown of YAP suppresses the proliferation of ATL cells in vitro and tumor formation in ATL-engrafted mice. Taken together, our results suggest that p65-induced YAP activation is essential for ATL pathogenesis and implicate YAP as a potential therapeutic target for ATL treatment.

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mentioning

confidence: 99%

HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis

Zhao

Wang

Fang

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“…In mammals, some viruses can affect the components of the Hippo pathway at the expression level. For instance, the molluscum contagiosum virus (MCV) and hepatitis B virus (HBV) upregulate YAP (the mammalian homolog of Yki ) expression in the skin peripheral keratinocytes and hepatocellular carcinoma, respectively ( 29 , 30 ). In cervical cancer and cervical precancerous lesions, the expression level of YAP is also correlated with the integration status of human papillomavirus (HPV) ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

et al. 2023

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“…Although it has been reported that MCV may inhibit innate immune responses, the underlying mechanism remains unclear. In the samples of MCV-infected patients, the expression of YAP and TAZ in the nucleus and cytoplasm of peripheral keratinocytes is significantly increased, compared to that of normal subjects (Seo et al, 2018). However, the expression of YAP in intracytoplasmic inclusions is markedly decreased in the upper level of the epidermis (Seo et al, 2018).…”

Section: Molluscum Contagiosum Virusmentioning

confidence: 94%

“…However, the expression of YAP in intracytoplasmic inclusions is markedly decreased in the upper level of the epidermis (Seo et al, 2018). The mRNA levels of YAP and TAZ in MC lesions are significantly increased compared to that of normal lesions (Seo et al, 2018).…”

Section: Molluscum Contagiosum Virusmentioning

confidence: 96%

“…In the samples of MCV-infected patients, the expression of YAP and TAZ in the nucleus and cytoplasm of peripheral keratinocytes is significantly increased, compared to that of normal subjects (Seo et al, 2018). However, the expression of YAP in intracytoplasmic inclusions is markedly decreased in the upper level of the epidermis (Seo et al, 2018). The mRNA levels of YAP and TAZ in MC lesions are significantly increased compared to that of normal lesions (Seo et al, 2018).…”

Section: Molluscum Contagiosum Virusmentioning

confidence: 97%

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The Hippo Pathway and Viral Infections

Wang

Zhang

et al. 2020

Front. Microbiol.

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The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control, cell proliferation, cancer development, and virus-induced diseases. In this review, we summarize the current understanding of the biological feature and pathological role of the Hippo pathway, focusing particularly on current findings in the function of the Hippo pathway in virus infection and pathogenesis.

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Expression of YAP and TAZ in molluscum contagiosum virus infected skin

Cited by 5 publications

References 8 publications

HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis

HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

The Hippo Pathway and Viral Infections

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