1993
DOI: 10.1016/0092-8674(93)90658-d
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Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

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Cited by 344 publications
(236 citation statements)
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“…Previous studies had suggested that genes may be expressed at a lower level from the X p in preimplantation embryos. (11)(12)(13) The current papers (1)(2)(3) that we discuss here further challenge the view that both X chromosomes are expressed in early stages of development by providing clear evidence of X p inactivation in preimplantation embryos.…”
Section: Introductionmentioning
confidence: 76%
See 1 more Smart Citation
“…Previous studies had suggested that genes may be expressed at a lower level from the X p in preimplantation embryos. (11)(12)(13) The current papers (1)(2)(3) that we discuss here further challenge the view that both X chromosomes are expressed in early stages of development by providing clear evidence of X p inactivation in preimplantation embryos.…”
Section: Introductionmentioning
confidence: 76%
“…(11,14,15) Xist RNA expression first appears at the 2-to 4-cell stage and this early expression of Xist is exclusively of paternal origin. (11) To follow early changes in global X-linked gene expression in mouse preimplantation embryos, Huynh and Lee used RNA fluorescence in situ hybridization (RNA-FISH) with a Cot-1 probe together with an Xist probe. (1) Active transcription as measured by the Cot-1 signal was first detected at the 2-cell stage, which is when zygotic gene activation commences.…”
Section: Introductionmentioning
confidence: 99%
“…The paternal X chromosome is selectively inactivated by imprinting in the extra-embryonic tissues, which give rise to the placenta and part of the extra-embryonic membranes (Takagi and Sasaki, 1975), where the paternal copy of Xist is always activated and the maternal one is never expressed (Kay et al, 1993). Targeted disruption of Tsix, when maternally inherited, induces ectopic activation of the normally silent copy of Xist on the same X chromosome in these tissues (Lee, 2000;Sado et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, imprinted genes are frequently linked within clusters that contain both maternally and paternally expressed genes (Zemel et al 1992;Mutirangura et al 1993;Rougeulle et al 1997;Vu and Hoffmann 1997;Wutz et al 1997). Finally, an unusual feature of these clusters is that they contain at least one imprinted gene that encodes an untranslated RNA (Brannan et al 1990;Kay et al 1993;Wevrick et al 1994;Wutz et al 1997).…”
mentioning
confidence: 99%