Expression of vimentin and CD44 in mucoepidermoid carcinoma: A role in tumor growth

Irani, Soussan; Jafari, Bahar

doi:10.4103/ijdr.ijdr_184_17

Cited by 13 publications

(6 citation statements)

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“…[ 51 ] Identifying the biomarkers of stem cells which acquire EMT characteristics may also improve the development of drugs targeting EMT CSCs. [ 52 53 54 55 ]…”

Section: Onclusionmentioning

confidence: 99%

The expression and functional significance of vascular endothelial-cadherin, CD44, and vimentin in oral squamous cell carcinoma

Irani¹,

Dehghan²

2018

J Int Soc Prevent Communit Dent

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Objectives:Ninety percent of head and neck cancers are squamous cell carcinoma which develops in the oral cavity. Metastasis is the main causative factor for death in 90% of all cancer-related deaths and begins with the invasion of tumor cells through the walls of small blood vessels or lymph vessels. A growing body of evidence has shown that vasculogenic mimicry (VM) facilitates tumor growth and cancer metastasis. The current study aimed to present the role of vascular endothelial (VE)-cadherin, CD44, and vimentin in inducing VM and epithelial-mesenchymal transition (EMT) and to identify the cancer stem cell (CSC) niche in different grades of oral squamous cell carcinoma (OSCC).Materials and Methods:A total of 63 OSCC samples (21 samples each grade) were collected from the archive of Pathology Department of Besat educational hospital, Hamadan, Iran, from 2000 to 2015. VE-cadherin, CD44, and vimentin/periodic acid–Schiff (PAS) double-staining were used to validate VM. VM was identified by the detection of PAS-positive loops surrounded by tumor cells. Chi-square test was used to examine the differences between the variables. Significant level was set at 0.05. Pearson's correlation was used to assess the co-localization of the markers.Results:There were statistically significant differences between tumor grade and the expression levels of VE-cadherin, CD44, and vimentin (P = 0.000). In addition, significant differences were found between tumor grade and microvessel density (P = 0.000) and between tumor grade and VM (P = 0.000).Conclusion:Our results may disclose a definite relationship between VE-cadherin, CD44 and vimentin expression levels, VM formation, EMT, CSCs, and microvessel count in OSCC samples. For this reason, it is suggested that VE-cadherin, CD44, and vimentin are related to angiogenesis and VM formation in OSCC, therefore, in tumor progression and metastasis. Recently, antitumor angiogenic therapies have been challenged. The presence of VM may explain the failure of antiangiogenic treatments.

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“…[ 51 ] Identifying the biomarkers of stem cells which acquire EMT characteristics may also improve the development of drugs targeting EMT CSCs. [ 52 53 54 55 ]…”

Section: Onclusionmentioning

confidence: 99%

The expression and functional significance of vascular endothelial-cadherin, CD44, and vimentin in oral squamous cell carcinoma

Irani¹,

Dehghan²

2018

J Int Soc Prevent Communit Dent

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“…VM formation involves tumor growth and cancer metastasis and in OSCC, it is correlated to highgrade tumors. On the other hand, VM formation is correlated to tumor plasticity and CSCs, a small subpopulation of cells within tumors, which are capable of selfrenewal, differentiation, and tumorigenicity (8,26). Supporting documents indicate that in highly aggressive epithelial cancers, VM formation promotes the overexpression of the mesenchymal phenotype through EMT phenomenon, which converts immobile epithelial cells to migratory mesenchymal cells (5,44).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed that the lower the differentiation level, the more abilities of cancer cell migration, invasion, and metastasis. In ad-dition, angiogenesis is critical for cancer progression and metastasis; hence, the number of vascular channels increases in cancer tissues to provide adequate nutrition for cancer cells (23,(25)(26)(27). Several molecules and signaling factors are involved in angiogenesis in cancers.…”

Section: Introductionmentioning

confidence: 99%

Endocan Expression Profile in Different Grades of Oral Squamous Cell Carcinoma

Irani

Amiri

2019

Int J Cancer Manag

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Background: Oral cancer is one of the most prevalent malignancies and presents increasing incidence and mortality trends in the world, with a mortality rate of 14.33%. Oral squamous cell carcinoma (OSCC) constitutes 90% of all malignancies in the oral cavity. In spite of new therapeutic strategies, the risk of metastasis and mortality rate is still very high. Methods: A total of 54 samples (18 samples of each grade) were collected from the archives of the Pathology Department of Be'sat Educational Hospital, Hamadan, Iran from 2000 to 2017. The specimens were processed for immunohistochemistry (IHC) analysis. Besides, the samples were stained with Periodic Acid-Schiff (PAS) method for vasculogenic mimicry (VM) detection. Results: The chi-square test showed statistically significant differences between the expression level of endocan and lesion grade in the research groups (P = 0.025), lesion grade and VM formation (P = 0.001), and tumor grade and microvessel density (MVD) count (P = 0.000). Conclusions: The results suggest that endocan mediates tumor progression possibly via a few mechanisms such as cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT), and VM formation. Further studies are required to reveal the mechanisms, by which the endocan acts as an oncogene. In addition, endocan could be considered as one of the tumor markers and a possible new target for cancer therapy.

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“…Tumor initiation [9]. Enhancement of proliferation and migration, and apoptosis inhibition in HNC [106,115].…”

Section: Cell Surface Markers Cd44mentioning

confidence: 99%

“…Moreover, a combination of three cancer stem cell markers - CD44, CD133 and SOX2 - was suggested to be a powerful and practicable prognosticator for patients with MEC of minor salivary glands [ 138 ]. Additionally, there was a positive correlation between CD44 and vimentin (a marker of EMT) expression level, and the levels of both CD44 and vimentin are associated with MEC tumor grade [ 115 ]. A previous study has reported that suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylases (HDACs), was capable of disrupting CSCs in MEC cell lines and sensitizing tumor cells to cisplatin treatment, emphasizing the role of MEC CSCs in the well-recognized resistance of salivary gland tumors to chemotherapy [ 139 ].…”

Section: Characterization Of Oral Non-scc Cancer Stem Cellsmentioning

confidence: 99%

Oral Cancer Stem Cells: Therapeutic Implications and Challenges

Shahoumi

2021

Front. Oral. Health

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Head and neck squamous cell carcinoma (HNSCC) is currently one of the 10 most common malignancies worldwide, characterized by a biologically highly diverse group of tumors with non-specific biomarkers and poor prognosis. The incidence rate of HNSCC varies widely throughout the world, with an evident prevalence in developing countries such as those in Southeast Asia and Southern Africa. Tumor relapse and metastasis following traditional treatment remain major clinical problems in oral cancer management. Current evidence suggests that therapeutic resistance and metastasis of cancer are mainly driven by a unique subpopulation of tumor cells, termed cancer stem cells (CSCs), or cancer-initiating cells (CICs), which are characterized by their capacity for self-renewal, maintenance of stemness and increased tumorigenicity. Thus, more understanding of the molecular mechanisms of CSCs and their behavior may help in developing effective therapeutic interventions that inhibit tumor growth and progression. This review provides an overview of the main signaling cascades in CSCs that drive tumor repropagation and metastasis in oral cancer, with a focus on squamous cell carcinoma. Other oral non-SCC tumors, including melanoma and malignant salivary gland tumors, will also be considered. In addition, this review discusses some of the CSC-targeted therapeutic strategies that have been employed to combat disease progression, and the challenges of targeting CSCs, with the aim of improving the clinical outcomes for patients with oral malignancies. Targeting of CSCs in head and neck cancer (HNC) represents a promising approach to improve disease outcome. Some CSC-targeted therapies have already been proven to be successful in pre-clinical studies and they are now being tested in clinical trials, mainly in combination with conventional treatment regimens. However, some studies revealed that CSCs may not be the only players that control disease relapse and progression of HNC. Further, clinical research studying a combination of therapies targeted against head and neck CSCs may provide significant advances.

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Expression of vimentin and CD44 in mucoepidermoid carcinoma: A role in tumor growth

Abstract: Our results may disclose a definite relationship between microvessl density (MVD), VM, EMT, and CSCs in MEC samples. Thus, it is reasonable to suggest that CSCs are related to angiogenesis and VM.

Cited by 13 publications

References 1 publication

The expression and functional significance of vascular endothelial-cadherin, CD44, and vimentin in oral squamous cell carcinoma

The expression and functional significance of vascular endothelial-cadherin, CD44, and vimentin in oral squamous cell carcinoma

Endocan Expression Profile in Different Grades of Oral Squamous Cell Carcinoma

Oral Cancer Stem Cells: Therapeutic Implications and Challenges

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