Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and the Surrounding Liver and Correlation with MRI Findings

Kanematsu, Masayuki; Osada, Shinji; Amaoka, Nozomi; Goshima, Satoshi; Kondo, Hiroshi; Kato, Hirohisa; Nishibori, Hironori; Yokoyama, Ryuichi; Hoshi, Hiroaki; Moriyama, Noriyuki

doi:10.2214/ajr.184.3.01840832

Cited by 24 publications

(25 citation statements)

References 18 publications

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“…134 In fact, blood vessel density and VEGF expression correlate directly with Child-Pugh score and the proliferative index, size and grade of HCC tumours. [135][136][137][138][139][140] A number of chemokines and their receptors are upregulated in the diseased liver and peripheral blood in the progression of liver fibrosis to cirrhosis and in the pathogenesis of malignant HCC. These molecules regulate inflammation, fibroproliferation, angiogenesis, carcinogenesis, metastasis, and anti-tumour immunity.…”

Section: Activatedmentioning

confidence: 99%

The role of chemokines in acute and chronic hepatitis C infection

2013

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Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of elaborate evasion strategies, hepatitis C virus (HCV) succeeds as a persistent human virus. It has an extraordinary capacity to subvert the immune response enabling it to establish chronic infections and associated liver disease. Chemokines are low molecular weight chemotactic peptides that mediate the recruitment of inflammatory cells into tissues and back into the lymphatics and peripheral blood. Thus, they are central to the temporal and spatial distribution of effector and regulatory immune cells. The interactions between chemokines and their cognate receptors help shape the immune response and therefore, have a major influence on the outcome of infection. However, chemokines represent a target for modulation by viruses including the HCV. HCV is known to modulate chemokine expression in vitro and may therefore enable its survival by subverting the immune response in vivo through altered leukocyte chemotaxis resulting in impaired viral clearance and the establishment of chronic low-grade inflammation. In this review, the roles of chemokines in acute and chronic HCV infection are described with a particular emphasis placed on chemokine modulation as a means of immune subversion. We provide an in depth discussion of the part played by chemokines in mediating hepatic fibrosis while addressing the potential applications for these chemoattractants in prognostic medicine.

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Section: Activatedmentioning

confidence: 99%

The role of chemokines in acute and chronic hepatitis C infection

2013

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“…Vascular properties of tumour tissue can be quantified by assessing the kinetics of the contrast agent [7,8]. Pharmacokinetic (PK) modelling can be used to provide quantitative information such as the volume transfer rate (k trans ) and extravascular extracellular volume fraction (v e ); these model parameters provide information about perfusion and permeability of tumour vasculature [5] and have been found to be related to prognostic factors [9]. As tissue vasculature can be assessed by DCE-MRI, its role in assessing antiangiogenic and anti-vascular therapies is increasing [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging

et al. 2012

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“…Hepatitis B virus infection may induce HCC in the absence of liver cirrhosis, while in patients with C virus hepatitisthe cirrhosis underlies all future pathologies. The inverse correlation between hepatic arterial vascularity and the expression of the VEGF level in HCV related HCC patients was found by Kanematsu et al [36], contrary to the experiences of Kwak et al [19] who found a positive correlation in the study of mostly HBV related HCC patients. Kanematsu justifiedthe divergence by the substantial differences in the Japanese patient's population and in the underlying hepatic disease.…”

Section: Discussionmentioning

confidence: 56%

“…Such observations could indicate either an inverse correlation between serum VEGF levels and various clinical and laboratory variables indicating advances of HCC or no correlation at all, as it is suggested, for instance, by Chen and his co-workers [35]. It should be noted, however, that most of the presented data on VEGF and HCC significant correlation originate from Chinese research centers, where HCC is frequently related to hepatitis B virus infection [22,36,37]. In our patients HCC tended to be related to HCV virus infection.…”

Section: Discussionmentioning

confidence: 99%

Hcc Angiogenic Propriety and Tumor Recurrence in Liver Transplant Recipients

Krawczyk¹

2015

Pharm Anal Acta

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Objective: Clinic-pathologic characteristic of hepatocellular carcinoma are mostly accounting for the tumor recurrence after liver transplantation. It is assumed that tumor angiogenesis capability contributes to the rates of post-transplant relapse, as well. The aim of study was to evaluate the contribution of the circulating hematopoietic stem cells (HSCs); endothelial progenitor cells (EPCs) and serum vascular endothelial growth factor (VEGF) to the recurrence of HCC after liver transplantation. Methods:The study was carried out on 49 cirrhotic patients with HCC within the Milan criteria. They were transplanted in 2009 and followed-up for 54 months, so far. The rates of circulating HSCs and EPCs were assessed through a phenotypic analysis of 2 ml of fresh blood in a flow cytometer. Serum VEGF concentration was measured by enzyme-linked immunoassay (ELISA). Histopathology examination of the liver explants was performed for tumor characteristic. The data were analyzed with statistical tests.Results: There were 9 deaths related to the procedure. Of 40 remaining patients the tumor recurred in 6 (15%) prior to 36 months and then in 5 (12.5%) prior to 54 months of observation. The pre-transplant rates of circulating HSCs and EPCs were significantly higher in patients with tumor relapse; Chisq=17.25, p<0.001 and Chisq=13.96, p<0.001, respectively. The differences in the serum VEGF concentration were not significant in this group, however. Conclusion:Tumor angiogenesis capability should be considered as the predictive factor of tumor relapse after liver transplantation.

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Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and the Surrounding Liver and Correlation with MRI Findings

Abstract: Our results indicate that the signal intensity and heterogeneity of hepatocellular carcinomas on MR images correlate with the degree of VEGF expression in hepatocellular carcinomas.

Cited by 24 publications

References 18 publications

The role of chemokines in acute and chronic hepatitis C infection

The role of chemokines in acute and chronic hepatitis C infection

Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging

Hcc Angiogenic Propriety and Tumor Recurrence in Liver Transplant Recipients

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