Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors

Yoshizawa, Kunio; Nozaki, Shinichi; Kitahara, Hiroko; Kato, Koroku; Noguchi, Naoto; Kawashiri, Shuichi; Yamamoto, Etsuhide

doi:10.3892/or.2011.1419

Cited by 21 publications

(30 citation statements)

References 19 publications

(21 reference statements)

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“…It has been shown that matrix metalloproteinase1 (MMP1), which is involved in the breakdown of extracellular matrix proteins, plays a role in tissue remodeling and metastasis [58][59][60] through collagen destruction, which causes progression in cardiac dysfunction [61]. The role of plasminogen activator urokinase (PLAU) and plasminogen activator tissue (PLAT) in extracellular matrix degradation and possible tumor cell migration and proliferation has also been highlighted [62][63][64][65]. ell cycle-related genes were downregulated through subsequent passages.…”

Section: Discussionmentioning

confidence: 99%

Cellular and Molecular Characterization of Human Cardiac Stem Cells Reveals Key Features Essential for Their Function and Safety

Vahdat

Mousavi

Omrani

et al. 2015

Stem Cells and Development

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Section: Discussionmentioning

confidence: 99%

Cellular and Molecular Characterization of Human Cardiac Stem Cells Reveals Key Features Essential for Their Function and Safety

Vahdat

Mousavi

Omrani

et al. 2015

Stem Cells and Development

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“…Also, lower expression of maspin was observed in the cell lines derived from high grades of OSCC. It seems that levels of uPA, uPAR and maspin may be useful prognostic markers in OSCC patients (20). Role of maspin in oral carcinoma is not understood.…”

Section: Pai-1 In Oral Cancermentioning

confidence: 99%

“…They showed that the presence of uPA enhanced cell invasion. Yoshizawa et al (20) studied the relationship between the clinicopathological findings and expression of uPA in oral squamous cell carcinoma (OSCC). They examined 54 cases of OSCC using reverse immuohistochemical techniques.…”

Section: Plasminogen Activation System In Oral Cancersmentioning

confidence: 99%

“…Yoshizawa et al (20) investigated the binding of uPA to uPAR in relation to cancer invasion and metastasis in OSCC patients. Using immunohistochemical techniques to assess the expression of uPA, uPAR in 54 cases and in six cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR), they showed a positive correlation with potential of cancer invasion.…”

Section: Pai-1 In Oral Cancermentioning

confidence: 99%

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Plasminogen activation system in oral cancer: Relevance in prognosis and therapy (Review)

Wyganowska‐Świątkowska

Jankun

2015

International Journal of Oncology

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Abstract.Research on carcinogenesis and progress in cancer treatment have reduced mortality of cancer patients. Mortality rates decreased by 1.5% per year from 2001 through 2010 for most types of cancer in men and women. However, oral cancer is still a significant global health problem since incidence and mortality rates are increasing. Oral cavity cancer is ranked the 8th in men and the 14th in women based on data collected between 2006 and 2010 by the National Institute of Health. Furthermore, an increasing incidence of head and neck neoplasms, particularly the tongue cancer among young adults has been reported recently. It is most likely due to increasing human papillomavirus (HPV) infection or the early start of tobacco and alcohol consumption. Treatment of oral cancer patients is mainly surgical and often leads to esthetic and functional deformities, with severe impact on the quality of life. Thus, novel form of treatments and selection of patients with high and low risk of mortality is of high priority for clinical studies. The expression of proteolytic enzymes in tumor and stromal tissues has been shown to have prognostic significance in many human cancers and inhibiting proteolysis can reduce tumor growth in many in vivo and in vitro models. Plasmin, with its activators and inhibitors are of great importance in many human malignances and collectively are called plasminogen activation system (PAS). In this comprehensive review we examine expression, possible prognostic markers and importance for therapy of the PAS members in oral cancer. Literature review suggests that overexpression of urokinase and its receptor are markers of poor outcome, thus, their inhibition can be explored in oral cancer therapy. Role of plasminogen activator inhibitor (PAI-1) is complex and depends on its concentration. Overexpression of PAI-1 favors angiogenesis, metastasis and poor prognosis, although when applied in very high concentrations it inhibits angiogenesis and tumor growth, the phenomenon is described as the PAI-1 paradox.

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“…Degradation of extracellular matrix and basement membrane caused by fibrin degradation and vascular formation effect are the key steps of tumurous invasion and metastasis. uPA (Urokinasetype Plasminogen Activator) can activate a variety of fibrinolytic enzymes, degrade extracellular matrix and basement membrane and promote tumurous infiltration and metastasis (Schmitt et al, 1997(Schmitt et al, , 2011Yoshizawa et al, 2011). The growth, infiltration and metastasis process of tumor depends on tumorous angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Relationships of uPA and VEGF Expression in Esophageal Cancer and Microvascular Density with Tumorous Invasion and Metastasis

Jiang

Zhang²,

Zhou³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors

Cited by 21 publications

References 19 publications

Cellular and Molecular Characterization of Human Cardiac Stem Cells Reveals Key Features Essential for Their Function and Safety

Cellular and Molecular Characterization of Human Cardiac Stem Cells Reveals Key Features Essential for Their Function and Safety

Plasminogen activation system in oral cancer: Relevance in prognosis and therapy (Review)

Relationships of uPA and VEGF Expression in Esophageal Cancer and Microvascular Density with Tumorous Invasion and Metastasis

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