Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin

Glucosamine alleviates zearalenone-induced damage to porcine trophectoderm cells by activating the PI3K/AKT signaling pathway

“…Numerous studies have shown that PI3K/AKT/mTORC1 pathway can integrate extracellular signals and affect cell transcription and translation processes by regulating the phosphorylation of the downstream ribosomal proteins P70S6K and 4E-BP1, thus participating in regulating physiological activities, such as cell growth and proliferation. 49,50…”

“…Numerous studies have shown that PI3K/AKT/mTORC1 pathway can integrate extracellular signals and affect cell transcription and translation processes by regulating the phosphorylation of the downstream ribosomal proteins P70S6K and 4E-BP1, thus participating in regulating physiological activities, such as cell growth and proliferation. 49,50 Furthermore, activation of the PI3K/AKT signaling pathway also inhibited the toxicity of ZEA. For example, ZEA can promote apoptosis by inhibiting the PI3K/AKT signaling pathway in mouse Leydig cells.…”

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas

“…Concerning another rare neoplasm, the murine salivary gland tumour (SGT), a study group detected a Smad and PTEN genes co-deletion that enhances its aggressiveness (48). Additionally, the combination of PTEN loss of expression due to mutations and the AKT/m TOR overactivation has been also reported in salivary gland secretory carcinoma (SSGC) (49). Similarly, PTEN mutations/deletions characterize a subset of the Carcinoma ex pleomorphic adenoma (CXPA).…”