Expression of  UCA1  and  MALAT1  long-chain non-coding RNAs in esophageal squamous cell carcinoma tissues is predictive of patient prognosis

Kang, Kai; Huang, Yonghua; Li, Haipeng; Guo, Shutao

doi:10.5114/aoms.2018.73713

Cited by 29 publications

(30 citation statements)

References 25 publications

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“…Relative to the 21,000 genes, more than 58,000 lncRNAs have been identified in humans [7]. Among these ln-cRNAs, many were further found to be deregulated in various diseases, including cancers [10][11][12][13][14]. Among these differently expressed lncRNAs, some were further verified to have important roles in a variety of pathophysiological statuses [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SNHG20 promotes prostate cancer progression via upregulating DDX17

Yan

et al. 2019

Arch Med Sci

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Introduction: Accumulating evidence has revealed the critical roles of long noncoding RNAs (lncRNAs) in various cancers. LncRNA SNHG20 has been shown to be a cancer-associated lncRNA in several cancers with diverse mechanisms. However, the clinical references, biological roles, and mechanisms of action of SNHG20 in prostate cancer (PCa) are still unclear. Material and methods: The expression of SNHG20 in PCa tissues and cell lines was detected by RT-qPCR. The correlations between SNHG20 expression and clinicopathological features were analyzed by χ 2 test. The roles of SNHG20 in PCa cell proliferation and migration were detected by CCK-8, EdU incorporation, and transwell assays. The regulatory mechanisms of SNHG20 on DDX17 were detected by dual luciferase reporter assay, RT-qPCR, and western blot. Results: SNHG20 is highly expressed in PCa tissues and cell lines. High expression of SNHG20 is positively correlated with high Gleason score and advanced tumor stage. Functional experiments revealed that overexpression of SNHG20 promotes PCa cell proliferation and migration. SNHG20 knockdown represses PCa cell proliferation and migration. Mechanistically, SNHG20 was verified to act as a competing endogenous RNA (ceRNA) to upregulate DDX17. DDX17 is also highly expressed and has oncogenic roles in PCa. Furthermore, the expression of DDX17 is significantly positively correlated with that of SNHG20 in PCa tissues. Depletion of DDX17 reverses the oncogenic roles of SNHG20 in PCa. Conclusions: These data showed that SNHG20 promotes PCa cell proliferation and migration via acting as a ceRNA to upregulate DDX17. This study also suggested that SNHG20 may be a potential novel therapeutic target for PCa.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SNHG20 promotes prostate cancer progression via upregulating DDX17

Yan

et al. 2019

Arch Med Sci

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“…Among these lncRNAs involving in the ceRNA network, Li et al have reported that Linc00483 acting as ceRNA regulated proliferation and apoptosis via activating mitogen‐activated protein kinases in gastric cancer. In addition, recent studies indicated that lncRNA UCA1 played important roles in the progression of various cancers, including papillary thyroid carcinoma, melanoma, esophageal squamous cell carcinoma, and breast cancer . In the previous study, HULC could act as an oncogene through negatively regulating miR‐125a‐3p in ovarian carcinoma .…”

Section: Discussionmentioning

confidence: 92%

“…In addition, recent studies indicated that lncRNA UCA1 played important roles in the progression of various cancers, including papillary thyroid carcinoma, melanoma, esophageal squamous cell carcinoma, and breast cancer. [38][39][40][41] In the previous study, HULC could act as an oncogene through negatively regulating miR-125a-3p in ovarian carcinoma. 42 Importantly, lncRNA HULC, which was activated by oxidative stress, could enhance CCA cellular migration and invasion by a ceRNA mechanism.…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide identification of a competing endogenous RNA network in cholangiocarcinoma

Liu

Zhang

et al. 2019

J of Cellular Biochemistry

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Cholangiocarcinoma (CCA) is the second widespread liver tumor with relatively poor survival. Increasing evidence in recent studies showed long noncoding RNAs (lncRNAs) exert a crucial impact on the development and progression of CCA based on the mechanism of competing endogenous RNAs (ceRNAs). However, functional roles and regulatory mechanisms of lncRNA‐regulated ceRNA in CCA, are only partially understood. The expression profile of messenger RNAs (mRNAs), lncRNAs, and microRNAs (miRNAs) downloaded from The Cancer Genome Atlas were comprehensively investigated. Differential expression of these three types of RNA between CCA and corresponding precancerous tissues were screened out for further analysis. On the basis of interactive information generated from miRDB, miRTarBase, TargetScan, and miRcode public databases, we then constructed an mRNA‐miRNA‐lncRNA regulatory network. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were conducted to identify the biological function of the ceRNA network involved in CCA. As a result, 2883 mRNAs, 136 miRNAs, and 993 lncRNAs were screened out as differentially expressed RNAs in CCA. In addition, a ceRNA network in CCA was constructed, composing of 50 up and 27 downregulated lncRNAs, 14 up and 7 downregulated miRNAs, 29 up and 25 downregulated mRNAs. Finally, gene set enrichment and pathway analysis indicated our CCA‐specific ceRNA network was related with cancer‐related pathway and molecular function. In conclusion, our research identified a novel lncRNA‐related ceRNA network in CCA, which might act as a potential therapeutic target for patients with CCA.

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“…According to Abrahamsen et al, invasive diagnostics are not necessary in patients with mild UA, and attentive observation is sufficient [13]. For now, it seems that research in patients with UA on the role of disorders related to notch signaling or long chain non-coding RNA is the future in prevention, prognosis or treatment, as is the case of many age-related diseases, including hematological malignancies and other cancers [26][27][28]. In our study however, during a 3-year follow-up, significantly more deaths were noted in the group with UA than in the group without anemia, even though the anemia was mild in most of the cases.…”

Section: Discussionmentioning

confidence: 99%

Unexplained anemia in the elderly – a real life analysis of 981 patients

Michalak¹,

Rupa‐Matysek²,

Hus³

et al. 2020

aoms

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Introduction: We aimed to analyze the prevalence of unexplained anemia (UA) and assess its characteristics, potential causes and impact on survival in an elderly population. Material and methods: Medical files of 981 patients aged ≥ 60 years consulted in one primary medical clinic in Poland in 2013-2014 were retrospectively analyzed. Anemia, defined according to WHO criteria, diagnosed during either hospitalization or outpatient treatment, from the age of 60, was included. Unexplained anemia was diagnosed if, based on available clinical data and laboratory tests and other assessments in medical records, none of the well-known types of anemia were identified. Results: Of 981 patients with anemia, UA was found in 48 (28.4%) patients (4.9% of those studied) and incidence increased with age (≥ 80 years, 12.3%). In 81.3% no full hematological diagnostics were performed. Patients with UA, as with those with defined anemia, when compared to the group without anemia were older, had more co-morbidities, were more frequently hospitalized, more frequently had dementia syndrome and obtained lower Barthel scores (p < 0.0001). In the groups of patients with UA and defined anemia, there were more deaths than in those without anemia (10% vs. 13% vs. 2%, p < 0.0001) with significant differences in survival rates observed during 3-year follow-up. Conclusions: The increasing incidence with age of UA in the elderly population, insufficient diagnosis and the higher mortality of patients with UA in comparison to the group without anemia indicate the need to develop recommendations for its management by primary care physicians.

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Expression of UCA1 and MALAT1 long-chain non-coding RNAs in esophageal squamous cell carcinoma tissues is predictive of patient prognosis

Cited by 29 publications

References 25 publications

Long noncoding RNA SNHG20 promotes prostate cancer progression via upregulating DDX17

Long noncoding RNA SNHG20 promotes prostate cancer progression via upregulating DDX17

Genome‐wide identification of a competing endogenous RNA network in cholangiocarcinoma

Unexplained anemia in the elderly – a real life analysis of 981 patients

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