Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion

Yang, Xiaojie; Jin, Jiamin; Yang, Jinfeng; Zhou, Lihua; Mi, Sisi; Qi, Guangying

doi:10.1590/1678-4685-gmb-2021-0058

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…The subsequent screening step by both title and abstract resulted in 23 studies being included. Full‐text screening of the included studies resulted in 14 being selected for review 1,4,6,17,37,44,49–58 . A flowchart that depicts the screening process is displayed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Full‐text screening of the included studies resulted in 14 being selected for review. 1 , 4 , 6 , 17 , 37 , 44 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 A flowchart that depicts the screening process is displayed in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Data from Sakata suggest that elevated HMGA2 expression may also be a novel potential biomarker for OSCC that may be used to predict distant metastases and prognosis. Gao et al 37 and Yang et al 55 discovered that CSN6 and USP7 were noticeably increased in OSCC tissues and cell lines, which is noticeably significant to the incidence of lymph node or distant metastases and poor prognosis of OSCC patients. They also confirmed that CSN6 may accelerate the malignant development of OSCC by controlling TIMP‐2.…”

Section: Discussionmentioning

confidence: 99%

“…Ubiquitin-specific-processing protease 7 Involved expression of various tumor-related genes, such as p53 and Ki-67, promotes the proliferation, and knockdown of USP7 increases p53 expression and inhibits cancer cell proliferation. 55,66 RARRES2 Retinoic acid receptor responder protein 2 It is upregulated in neuroblastoma, esophageal squamous cell carcinoma, and OSCC. 56,67 Abbreviations: EGFR, estimated glomerular filtration rate; OSCC, oral squamous cell carcinoma; PKC, protein kinase C.…”

Section: Usp7mentioning

confidence: 99%

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Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Mohtasham,

Zarepoor,

Shooshtari

et al. 2024

Health Science Reports

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Background and AimsOral squamous cell carcinoma is the most prevalent malignancy in the oral cavity, with a significant mortality rate. In oral squamous cell carcinoma patients, the survival rate could decrease because of delayed diagnosis. Thus, prevention, early diagnosis, and appropriate treatment can effectively increase the survival rate in patients. In this systematic review, we discussed the role of different genes in oral squamous cell carcinoma metastasis. Herein, we aimed to summarize clinical results, regarding the potential genes that promote oral squamous cell carcinoma metastasis.MethodsThis systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non‐English language.ResultsA total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon‐induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high‐mobility group A2 (HMGA2), transformed growth factor‐beta‐induced, lectin galactoside‐binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5′−3′ exoribonuclease 2 (XRN2), cystatin‐A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin‐3, also known as P‐cadherin and Wnt family member 5A, ubiquitin‐specific‐processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.ConclusionStudies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Usp7mentioning

confidence: 99%

See 2 more Smart Citations

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Mohtasham,

Zarepoor,

Shooshtari

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…IFN is not toxic to the cell itself, but it inhibits the replication of a variety of viruses and possesses antitumor activity [142] . EZH2-CCF-cGAS signaling [129] MDM2/MDMX-p53 pathway [130] FBP1-DNMT1 pathway [131] NEDD4L-SMAD pathway [132] Cell cycle and EMT pathway [133] JMJD3/CLU signaling [81] p53/TfR1 pathway [134] Wnt/β-catenin signaling [39] PI3K/Akt pathway [124] Hippo pathway [107] Akt/ERK signaling [135] NF-κB signaling [136] AMPK pathway [124] Shh pathway [16] NOX4/NLRP3 pathway [137] Glucose Metabolism signaling [138] So×9-PTHrP-PTH1R axis [58] Insulin/IGF-1-like signaling [88] HIF-1α signaling pathway [139] Hedgehog signaling [140] Shoc2-ERK1/2 pathway [141] [143,144] . For example, in response to virus invasion, the body produces IFN, and the process is mediated by several factors.…”

Section: The Roles Of Usp7 In Viral Infection and Inflammationmentioning

confidence: 99%

Recent insights into USP7: Construct, pathophysiology, and inhibitors

He¹,

Zhong²,

Wang³

et al. 2022

Gene Protein Dis

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The ubiquitin-proteasome pathway (UPP) is essential for proteostasis and cellular homeostasis. Most of the human proteins are degraded through the UPP in which proteins should be tagged with a specific polyubiquitin chain in a sequential cascade of E1 ubiquitin (Ub)-activating enzymes, namely, E2 Ub-conjugating enzymes and E3 Ub ligases. Meanwhile, the ubiquitination process can be reversed by deubiquitinating enzymes (DUBs), which protect the target proteins from ubiquitination, and so far, around 100 DUBs have been reported to present in human cells. Ubiquitin-specific protease 7 (USP7) is a member of the DUBs family, which has been reported to play crucial role in the development of human tumors and diseases; however, the molecular mechanisms of disease and malignant tumor progression mediated by USP7 has not been fully elucidated. In addition, the therapeutic potential of USP7 in cancer treatment remains to be further explored. Therefore, this review begins with a review of the structure and function of USP7, and then focuses on the development of USP7 inhibitors and their potential applications in various human diseases.

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Research Progress of Ubiquitin-Specific Pep-tidases in Head and Neck Squamous Cell Carcinoma

张¹

2022

ACM

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Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion

Cited by 5 publications

References 28 publications

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

Recent insights into USP7: Construct, pathophysiology, and inhibitors

Research Progress of Ubiquitin-Specific Pep-tidases in Head and Neck Squamous Cell Carcinoma

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