Expression of type I interferon receptor in renal cell carcinoma.

Increased interferon alpha receptor 2 mRNA levels is associated with renal cell carcinoma metastasis

“…A previous report found no relationship between type 1 IFNAR expression levels in clear cell RCC tumors and stage, grade, gender, age or survival [ 15 ]. However, our observation that the relative value of the T/N ratio but not the absolute level of IFNAR2 mRNA in tumor tissues correlated with the malignant and metastatic profiles of RCCs is puzzling even if there is inter-individual variations and should be investigated in future studies.…”

Immunotherapy of Metastatic Renal Cell Cancer

“…31 However, renal cancer cells themselves bear receptors for these (and other) cytokines and may secrete soluble IL-2 receptor that affects the interaction of the IL-2 with the lymphocyte IL-2 receptor. In the clinical setting, it is not realistic to try to separate the effects on tumor cell IFN receptor, 43,44 tumor cell IL-2 receptor, 45,46 soluble IL-2 receptor, or CTL and NK subsets. Suffice to say the "conventional anticancer drug" direct-action mechanism may have a role in some of the responses that are observed.…”

Pattern of metastases in renal cell carcinoma: A single institution study

“…Newer prognostic indicators include nuclear grading, histological subtype, [11] functional status (Eastern Cooperative Oncology Group [ECOG], and molecular markers (Ki 67, silver staining nucleolar organizing regions, proliferating cell nuclear antigens, and carbonic anhydrase expression). [12][13][14] Although several authors have included a combination of such newer prognostic factors to structure outcome prediction models and postoperative nomograms, these have not been currently included in the clinical TNM classification. [15,16] Although such prognostic models, becoming more inclusive and complex may eventually replace or find place as addition to the existing TNM classification, we chose to utilize the currently existing practical tool to evaluate our data.…”