1995
DOI: 10.1165/ajrcmb.13.3.7654383
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Expression of tumor necrosis factor receptors in human lung cancer cells and normal lung tissues.

Abstract: The purpose of this study was to investigate the expression of tumor necrosis factor (TNF) receptors for the control of the biologic action of TNF-alpha in lung cancer cells and normal lung tissues. Lung cancer specimens and normal lung tissues were freshly obtained in pairs from 15 patients who underwent surgery for lung cancer. Thirteen lung cancer specimens expressed the 55 kDa TNF receptor messenger RNA (mRNA), whereas only six lung cancer specimens expressed the 75 kDa TNF receptor mRNA by Northern blot a… Show more

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Cited by 30 publications
(27 citation statements)
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“…Activation of NF-nB by TNF-a in noninflammatory cells, such as NSCLC tumor cells, requires binding to TNFR1 (26,27). Thus, we decided to start by characterizing the effect of HDIs on TNFR1 gene expression in a panel of NSCLC cell lines from all three NSCLC subtypes.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Activation of NF-nB by TNF-a in noninflammatory cells, such as NSCLC tumor cells, requires binding to TNFR1 (26,27). Thus, we decided to start by characterizing the effect of HDIs on TNFR1 gene expression in a panel of NSCLC cell lines from all three NSCLC subtypes.…”
Section: Resultsmentioning
confidence: 99%
“…We did a thorough analysis of the influence of HDIs on the well-defined NSCLC cell lines, A549 and NCI-H460, in which TNFR1 is the only TNF-a receptor present (26,27). Accordingly, the reduction in TNFR1 expression correlated with dramatic consequences for the inducibility of the NF-nB pathway: delayed InB-a phosphorylation, retarded InB-a degradation, a subsequent block in the translocation of NF-nB from the cytosol to the nucleus, and finally reduced NF-nB DNA binding and target gene expression.…”
Section: Discussionmentioning
confidence: 99%
“…The human A549 and U937 cell lines express TNFR-1 mRNA and TNFR-2 mRNA respectively (Iwamoto et al 1994, Shimomoto et al 1995. Total RNA extracted from these cells was subjected to RT-PCR in parallel with ACHN samples.…”
Section: Characterisation Of Tnf Receptors Regulating Et-2 Releasementioning
confidence: 99%
“…TNF-␣ acts through activation of two receptors: a 55-kDa (p55) form designated TNFR1 and a 75-kDa (p75) form designated TNFR2. Both TNFR1 and TNFR2 could be detected in human lung tissue (15,16). TNFR1 is found mainly on alveolar macrophages, bronchioles, and small blood vessels, while TNFR2 was detectable only in alveolar macrophages (16).…”
mentioning
confidence: 95%
“…Both TNFR1 and TNFR2 could be detected in human lung tissue (15,16). TNFR1 is found mainly on alveolar macrophages, bronchioles, and small blood vessels, while TNFR2 was detectable only in alveolar macrophages (16). Also, on sensory neurons both TNFR1 and TNFR2 can be detected (17,18).…”
mentioning
confidence: 99%