Expression of Tumor Necrosis Factor-alpha-induced Protein 8 in Pancreas Tissues and its Correlation with Epithelial Growth Factor Receptor Levels

Abstract

Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified protein considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and to analyse its correlation with clinicopathological significance and the expression levels of epithelial growth factor receptor (EGFR), immunohistochemistry was performed to detect the TNFAIP8 and EGFR proteins in pancreatic cancers, pancreatitis tissues, and healthy controls. The results showed stronger staining of TNFAIP8 protein in pancreatic cancer tissues compared with normal pancreas tissue. Furthermore, in 56 patients with pancreatic cancer, the expression levels of TNFAIP8 in patients with low tumor stage was higher than that with high tumor stage, and correlated with tumor staging and lymph node metastasis (P<0.05). Furthermore, TNFAIP8 expression positively correlated with EGFR levels (r=0.671135, P<0.05). These results indicate that TNFAIP8 may play important roles in the progression of pancreatic cancer.

TNFAIP8 as a predictor of metastasis and a novel prognostic biomarker in patients with epithelial ovarian cancer

“…In line with the possible role of TNFAIP8 in human tumorigenesis, previous studies have proven that TNFAIP8 overexpression was detected in several human malignant tumours at both mRNA and protein levels (Kumar et al , 2004; Dong et al , 2010; Hadisaputri et al , 2012; Liu et al , 2012; Miao et al , 2012). Positive correlations of TNFAIP8 with histologic grade, residual tumour size, recurrence and metastases of the peritoneum and lymph node have been demonstrated in the current study.…”

“…Positive correlations of TNFAIP8 with histologic grade, residual tumour size, recurrence and metastases of the peritoneum and lymph node have been demonstrated in the current study. The elevated TNFAIP8 expression that correlates with tumour stage and lymph node metastasis was observed in pancreatic cancer, colon cancer, NSCLC and oesophageal squamous cell cancer (Dong et al , 2010; Hadisaputri et al , 2012; Liu et al , 2012; Miao et al , 2012). In NSCLC and oesophageal squamous cell cancer, TNFAIP8 was proven to be a poor prognostic marker, although it was not an independent factor (Dong et al , 2010; Hadisaputri et al , 2012).…”

“…With regard to the possible role of TNFAIP8 in tumorigenesis and its progression, TNFAIP8 overexpression has frequently occurred in several types of cancer tissues and has exhibited clinical relevance (Kumar et al , 2004; Dong et al , 2010; Hadisaputri et al , 2012; Liu et al , 2012; Miao et al , 2012; Zhang et al , 2012, 2013; Shi et al , 2013). As of this writing, no studies on TNFAIP8 in primary EOC tissues have been conducted.…”

Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins

“…It was originally known as SCC-C2, as it was found in a cell line derived from metastatic head and neck squamous cell cancer and was determined to be a negative regulator of apoptosis in overexpression assays. 17,20,25 Its expression levels correlate with the tumor, node, metastasis (TNM) staging of esophageal squamous cell carcinoma, 26 and a similar pattern has been observed in pancreatic cancer, 27 gastric adenocarcinoma 28 and endometrial cancer. 29 It is also a risk factor for non-Hodgkin's lymphoma, and high levels of TNFAIP8 expression are associated with more aggressive forms of epithelial ovarian cancer with poor survival rates 22,30 as well as with non-small cell lung cancer (NSCLC).…”

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

“…There may be a lot of factors involved. For instance, the overexpression of epidermal growth factorreceptor (EGF-R) is one of the most frequently detected genetic changes in the initial stages of pancreatic cancer and greatly correlates with the progression, invasion and metastasis of pancreatic cancer (Liu et al, 2012), and annexin A1 is happened to be a substrate for EGFstimulated tyrosine kinase and can be phosphorylated by EGF-R tyrosine kinase to mediate proliferation. Therefore, when pancreatic cancer initiated and developed, EGFR expression increased, consequently annexin A1 was phosphorylated to play its part, and then the annexin A1 expression increased as a feedback.…”