Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma

Bai, Jing; Liu, Xiangyi; Zhang, Shurong; Dang, Shoutao; Zhang, Yong; Zhang, Guojun

doi:10.14715/cmb/2022.68.6.9

Cited by 1 publication

(2 citation statements)

References 37 publications

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“…Chronic inflammation is believed to contribute to the development and progression of SCC. The overexpression of TLR4 was observed in SCC-affected skin compared to normal skin [44]. TLR4 activation increases the production of the proinflammatory cytokines TNF-α and TGF-β while inhibiting the anti-inflammatory IL-10.…”

Section: Experimental Evidence Of the Role Of Microbiota In Skin Carc...mentioning

confidence: 93%

“…The increased expression of TLRs has been observed in skin tumors. Several studies have investigated the role of TLR4 in SCC, particularly in the context of inflammation and the tumor microenvironment [39,[43][44][45]. Chronic inflammation is believed to contribute to the development and progression of SCC.…”

Section: Experimental Evidence Of the Role Of Microbiota In Skin Carc...mentioning

confidence: 99%

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Role of the Microbiota in Skin Neoplasms: New Therapeutic Horizons

Savoia,

Azzimonti,

Rolla

et al. 2023

Microorganisms

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The skin and the gut are regularly colonized by a variety of microorganisms capable of interacting with the immune system through their metabolites and influencing the balance between immune tolerance and inflammation. Alterations in the composition and diversity of the skin microbiota have been described in various cutaneous diseases, including skin cancer, and the actual function of the human microbiota in skin carcinogenesis, such as in progression and metastasis, is currently an active area of research. The role of Human Papilloma Virus (HPV) in the pathogenesis of squamous cell carcinoma is well consolidated, especially in chronically immunosuppressed patients. Furthermore, an imbalance between Staphylococcus spp., such as Staphylococcus epidermidis and aureus, has been found to be strongly related to the progression from actinic keratosis to squamous cell carcinoma and differently associated with various stages of the diseases in cutaneous T-cell lymphoma patients. Also, in melanoma patients, differences in microbiota have been related to dissimilar disease course and prognosis and may affect the effectiveness and tolerability of immune checkpoint inhibitors, which currently represent one of the best chances of a cure. From this point of view, acting on microbiota can be considered a possible therapeutic option for patients with advanced skin cancers, even if several issues are still open.

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Section: Experimental Evidence Of the Role Of Microbiota In Skin Carc...mentioning

confidence: 93%