Expression of toll-like receptors in cartilage endplates cells: a role of toll-like receptor 2 in pro-inflammatory and -catabolic gene expression
Tamara Mengis,
Laura Bernhard,
Nick Herger
et al.
Abstract:Introduction
The vertebral cartilage endplate (CEP), essential for intervertebral disc health, is susceptible to degeneration, which can be associated with chronic low back pain, disc degeneration, and Modic changes. Although it has been established that intervertebral disc cells express toll-like receptors (TLRs), which can recognize diverse pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), triggering an immune response, it is unknown whether CEP cells (CEPC) sha… Show more
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